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Procedure price report · Pathology

SMPD1 gene test for common variants

CPT 81330the billing code this page is about

Laboratory test that checks the SMPD1 gene for a small set of frequently seen changes associated with an inherited metabolic storage disease.

Hospitals typically charge $134 cash for this outpatient procedure — the median across 534 hospitals that filed a usable cash price; the average of the middle 60% is $149. Most fall between $52 and $327 (20th–80th percentile).

Hospitals
534
States
42
Filings dated
Sep 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 534 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$37$64$134$266$733

The most expensive tenth of hospitals charges at least 20× what the cheapest tenth charges ($37 vs $733).

How the prices are spread

$29 – $41: 36 hospitals$29$41 – $58: 65 hospitals$58 – $83: 63 hospitals$58$83 – $119: 48 hospitals$119 – $171: 83 hospitals$119$171 – $244: 79 hospitals$244 – $349: 52 hospitals$244$349 – $500: 11 hospitals$500 – $715: 19 hospitals$500$715 – $1,023: 31 hospitals$715median $134price bands are equal on a log scale
Hospitals per price band (487 of 534 — the bands cover the 5th to 95th percentile)
FromToHospitals
$29$4136
$41$5865
$58$8363
$83$11948
$119$17183
$171$24479
$244$34952
$349$50011
$500$71519
$715$1,02331

By state

The median cash price in each state, against the national median of $134.

Alaska: 2 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 7 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: 5 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $73 across 17 hospitalsWA$73Idaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 1 hospital filed a usable price — fewer than 10, so no figureNDMinnesota: median $90 across 17 hospitalsMN$90Illinois: median $140 across 25 hospitalsIL$140Wisconsin: median $160 across 17 hospitalsWI$160Michigan: median $36 across 19 hospitalsMI$36New York: median $71 across 33 hospitalsNY$71Massachusetts: median $202 across 20 hospitalsMA$202Oregon: 2 hospitals filed a usable price — fewer than 10, so no figureORNevada: 4 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $128 across 12 hospitalsIA$128Indiana: median $97 across 28 hospitalsIN$97Ohio: median $331 across 55 hospitalsOH$331Pennsylvania: median $226 across 34 hospitalsPA$226New Jersey: median $52 across 34 hospitalsNJ$52Connecticut: 5 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $134 across 29 hospitalsCA$134Utah: 2 hospitals filed a usable price — fewer than 10, so no figureUTColorado: 5 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: median $230 across 10 hospitalsMO$230Kentucky: median $331 across 14 hospitalsKY$331West Virginia: 2 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: 6 hospitals filed a usable price — fewer than 10, so no figureVAMaryland: median $236 across 11 hospitalsMD$236Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 4 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 3 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 5 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: no hospital in the corpus filed a usable priceARTennessee: 6 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: median $198 across 23 hospitalsNC$198South Carolina: no hospital in the corpus filed a usable priceSCOklahoma: 8 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 6 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: 4 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 5 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: no hospital in the corpus filed a usable priceGAHawaii: 1 hospital filed a usable price — fewer than 10, so no figureHITexas: median $240 across 31 hospitalsTX$240Florida: median $80 across 17 hospitalsFL$80
Cash price by state, most expensive first. National median $134. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Kentucky KY14$331+147%$100 – $1,664
Ohio OH55$331+147%$152 – $733
Texas TX31$240+79%$29 – $240
Maryland MD11$236+76%$21 – $321
Missouri MO10$230+72%$156 – $230
Pennsylvania PA34$226+69%$34 – $1,023
Massachusetts MA20$202+51%$70 – $505
North Carolina NC23$198+48%$87 – $649
Wisconsin WI17$160+20%$135 – $189
Illinois IL25$140+5%$109 – $155
California CA29$1340%$35 – $134
Iowa IA12$128−4%$128 – $128
Indiana IN28$97−28%$68 – $247
Minnesota MN17$90−33%$27 – $173
Florida FL17$80−40%$76 – $105
Washington WA17$73−46%$45 – $73
New York NY33$71−47%$47 – $294
New Jersey NJ34$52−61%$47 – $1,330
Michigan MI19$36−73%$31 – $65
Oklahoma OK8not enough hospitals filed a usable price
Maine ME7not enough hospitals filed a usable price
Louisiana LA6not enough hospitals filed a usable price
Tennessee TN6not enough hospitals filed a usable price
Virginia VA6not enough hospitals filed a usable price
Alabama AL5not enough hospitals filed a usable price
Colorado CO5not enough hospitals filed a usable price
Connecticut CT5not enough hospitals filed a usable price
Kansas KS5not enough hospitals filed a usable price
New Hampshire NH5not enough hospitals filed a usable price
Arizona AZ4not enough hospitals filed a usable price
Mississippi MS4not enough hospitals filed a usable price
Nevada NV4not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
New Mexico NM3not enough hospitals filed a usable price
Alaska AK2not enough hospitals filed a usable price
Oregon OR2not enough hospitals filed a usable price
Utah UT2not enough hospitals filed a usable price
West Virginia WV2not enough hospitals filed a usable price
Hawaii HI1not enough hospitals filed a usable price
North Dakota ND1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $134.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care466$134$52 – $321
Children’s17fewer than 20 hospitals
Critical access46$152$84 – $331
Ownership
For-profit27$95$53 – $160
Government50$97$47 – $266
Non-profit452$140$52 – $331
System affiliation
Part of a system485$134$52 – $328
Independent49$118$54 – $203

Cash price vs list price

Median list price (chargemaster)$239
Median cash price$134
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

367 hospitals filed a usable inpatient cash price for this code. The median is $152 and the average of the middle 60% is $165; most fall between $62 and $294.

Cash price percentiles, inpatient, across 367 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$35$83$152$247$641

The most expensive tenth of hospitals charges at least 19× what the cheapest tenth charges ($35 vs $641).

Of the 393 hospitals that filed this code inpatient, 367 gave a usable cash price; 18 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 8 a list price only.

How complete is this

534 of the 3,956 hospitals with a price file in our corpus (13%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 573 hospitals that filed this code at all gave us
Usable cash price — counted534
Cash price carrying a plausibility flag — shown on the compare tool, excluded here32
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded7
Hospitals that filed this code573

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as SMPD1 GENE COMMON VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “SMPD1 gene test for common variants (CPT 81330) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81330-smpd1-gene-test-for-common-variants