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Procedure price report · Pathology

Connexin 26 gene test for a known family variant

CPT 81253the billing code this page is about

A laboratory test that checks a sample only for a specific GJB2 gene change already identified in a relative, rather than sequencing the whole gene.

Hospitals typically charge $141 cash for this outpatient procedure — the median across 229 hospitals that filed a usable cash price; the average of the middle 60% is $193. Most fall between $74 and $442 (20th–80th percentile).

Hospitals
229
States
34
Filings dated
Oct 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 229 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$62$74$141$378$734

The most expensive tenth of hospitals charges at least 12× what the cheapest tenth charges ($62 vs $734).

How the prices are spread

$62 – $80: 58 hospitals$62$80 – $103: 33 hospitals$103 – $134: 15 hospitals$103$134 – $174: 24 hospitals$174 – $226: 9 hospitals$174$226 – $293: 8 hospitals$293 – $379: 21 hospitals$293$379 – $492: 26 hospitals$492 – $638: 5 hospitals$492$638 – $827: 17 hospitals$638median $141price bands are equal on a log scale
Hospitals per price band (216 of 229 — the bands cover the 5th to 95th percentile)
FromToHospitals
$62$8058
$80$10333
$103$13415
$134$17424
$174$2269
$226$2938
$293$37921
$379$49226
$492$6385
$638$82717

By state

The median cash price in each state, against the national median of $141.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: median $98 across 13 hospitalsWA$98Idaho: 1 hospital filed a usable price — fewer than 10, so no figureIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: median $440 across 11 hospitalsMN$440Illinois: median $130 across 12 hospitalsIL$130Wisconsin: median $450 across 12 hospitalsWI$450Michigan: median $442 across 13 hospitalsMI$442New York: median $62 across 16 hospitalsNY$62Massachusetts: 3 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 3 hospitals filed a usable price — fewer than 10, so no figureORNevada: 2 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: no hospital in the corpus filed a usable priceIAIndiana: median $89 across 12 hospitalsIN$89Ohio: median $820 across 18 hospitalsOH$820Pennsylvania: median $767 across 15 hospitalsPA$767New Jersey: median $68 across 22 hospitalsNJ$68Connecticut: 4 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $141 across 21 hospitalsCA$141Utah: no hospital in the corpus filed a usable priceUTColorado: 2 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 2 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 2 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: no hospital in the corpus filed a usable priceWVVirginia: 5 hospitals filed a usable price — fewer than 10, so no figureVAMaryland: 1 hospital filed a usable price — fewer than 10, so no figureMDDelaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: 2 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: 1 hospital filed a usable price — fewer than 10, so no figureKSArkansas: 1 hospital filed a usable price — fewer than 10, so no figureARTennessee: 1 hospital filed a usable price — fewer than 10, so no figureTNNorth Carolina: 1 hospital filed a usable price — fewer than 10, so no figureNCSouth Carolina: no hospital in the corpus filed a usable priceSCOklahoma: 3 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 3 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: 2 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 1 hospital filed a usable price — fewer than 10, so no figureALGeorgia: 5 hospitals filed a usable price — fewer than 10, so no figureGAHawaii: no hospital in the corpus filed a usable priceHITexas: median $74 across 16 hospitalsTX$74Florida: 2 hospitals filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $141. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Ohio OH18$820+481%$633 – $827
Pennsylvania PA15$767+444%$308 – $899
Wisconsin WI12$450+219%$84 – $450
Michigan MI13$442+213%$85 – $442
Minnesota MN11$440+212%$375 – $440
California CA21$1410%$141 – $141
Illinois IL12$130−8%$99 – $130
Washington WA13$98−30%$93 – $106
Indiana IN12$89−37%$78 – $120
Texas TX16$74−48%$74 – $74
New Jersey NJ22$68−52%$62 – $68
New York NY16$62−56%$62 – $74
Georgia GA5not enough hospitals filed a usable price
Virginia VA5not enough hospitals filed a usable price
Connecticut CT4not enough hospitals filed a usable price
Louisiana LA3not enough hospitals filed a usable price
Massachusetts MA3not enough hospitals filed a usable price
Oklahoma OK3not enough hospitals filed a usable price
Oregon OR3not enough hospitals filed a usable price
Arizona AZ2not enough hospitals filed a usable price
Colorado CO2not enough hospitals filed a usable price
Florida FL2not enough hospitals filed a usable price
Kentucky KY2not enough hospitals filed a usable price
Missouri MO2not enough hospitals filed a usable price
Mississippi MS2not enough hospitals filed a usable price
Nevada NV2not enough hospitals filed a usable price
Alabama AL1not enough hospitals filed a usable price
Arkansas AR1not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price
Idaho ID1not enough hospitals filed a usable price
Kansas KS1not enough hospitals filed a usable price
Maryland MD1not enough hospitals filed a usable price
North Carolina NC1not enough hospitals filed a usable price
Tennessee TN1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $141.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care185$130$68 – $335
Children’s13fewer than 20 hospitals
Critical access29$375$103 – $450
Ownership
For-profit9fewer than 20 hospitals
Government27$103$62 – $335
Non-profit191$141$74 – $442
System affiliation
Part of a system204$132$74 – $442
Independent25$220$76 – $352

Cash price vs list price

Median list price (chargemaster)$395
Median cash price$141
Cash as a share of list, median hospital56%

At the typical hospital, asking for the cash price cuts the list price by about 44%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

144 hospitals filed a usable inpatient cash price for this code. The median is $301 and the average of the middle 60% is $283; most fall between $98 and $577.

Cash price percentiles, inpatient, across 144 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$74$116$301$450$827

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($74 vs $827).

Of the 156 hospitals that filed this code inpatient, 144 gave a usable cash price; 2 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 10 a list price only.

How complete is this

229 of the 3,956 hospitals with a price file in our corpus (6%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 244 hospitals that filed this code at all gave us
Usable cash price — counted229
Cash price carrying a plausibility flag — shown on the compare tool, excluded here4
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded10
Hospitals that filed this code244

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as GJB2 GENE KNOWN FAM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Connexin 26 gene test for a known family variant (CPT 81253) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81253-connexin-26-gene-test-for-a-known-family-variant