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Procedure price report · Pathology

CYP3A5 drug-processing gene test, common variants

CPT 81231the billing code this page is about

A genetic test of the CYP3A5 gene that checks for the common variants affecting how the body breaks down certain medicines.

Hospitals typically charge $238 cash for this outpatient procedure — the median across 577 hospitals that filed a usable cash price; the average of the middle 60% is $266. Most fall between $122 and $537 (20th–80th percentile).

Hospitals
577
States
45
Filings dated
Dec 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 577 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$77$142$238$500$784

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($77 vs $784).

How the prices are spread

$38 – $53: 19 hospitals$38$53 – $76: 19 hospitals$76 – $107: 28 hospitals$76$107 – $151: 88 hospitals$151 – $214: 100 hospitals$151$214 – $302: 91 hospitals$302 – $428: 50 hospitals$302$428 – $605: 88 hospitals$605 – $855: 26 hospitals$605$855 – $1,210: 37 hospitals$855median $238price bands are equal on a log scale
Hospitals per price band (546 of 577 — the bands cover the 5th to 95th percentile)
FromToHospitals
$38$5319
$53$7619
$76$10728
$107$15188
$151$214100
$214$30291
$302$42850
$428$60588
$605$85526
$855$1,21037

By state

The median cash price in each state, against the national median of $238.

Alaska: 2 hospitals filed a usable price — fewer than 10, so no figureAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: 9 hospitals filed a usable price — fewer than 10, so no figureWAIdaho: 1 hospital filed a usable price — fewer than 10, so no figureIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 4 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $528 across 17 hospitalsMN$528Illinois: median $307 across 32 hospitalsIL$307Wisconsin: median $540 across 33 hospitalsWI$540Michigan: median $241 across 17 hospitalsMI$241New York: median $307 across 26 hospitalsNY$307Massachusetts: 6 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 5 hospitals filed a usable price — fewer than 10, so no figureORNevada: 6 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 4 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $168 across 14 hospitalsIA$168Indiana: median $218 across 28 hospitalsIN$218Ohio: median $481 across 68 hospitalsOH$481Pennsylvania: median $174 across 24 hospitalsPA$174New Jersey: median $192 across 24 hospitalsNJ$192Connecticut: 6 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $1,210 across 27 hospitalsCA$1,210Utah: 1 hospital filed a usable price — fewer than 10, so no figureUTColorado: 9 hospitals filed a usable price — fewer than 10, so no figureCONebraska: 3 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: 7 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: median $290 across 14 hospitalsKY$290West Virginia: 2 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $262 across 24 hospitalsVA$262Maryland: median $1,103 across 13 hospitalsMD$1,103Delaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: 6 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 2 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 1 hospital filed a usable price — fewer than 10, so no figureKSArkansas: 4 hospitals filed a usable price — fewer than 10, so no figureARTennessee: 6 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: 2 hospitals filed a usable price — fewer than 10, so no figureNCSouth Carolina: median $146 across 18 hospitalsSC$146Oklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 4 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: median $214 across 11 hospitalsMS$214Alabama: 3 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $245 across 18 hospitalsGA$245Hawaii: 3 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $72 across 53 hospitalsTX$72Florida: median $142 across 16 hospitalsFL$142
Cash price by state, most expensive first. National median $238. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA27$1,210+408%$123 – $1,210
Maryland MD13$1,103+364%$63 – $1,504
Wisconsin WI33$540+127%$338 – $549
Minnesota MN17$528+122%$446 – $675
Ohio OH68$481+102%$122 – $1,037
New York NY26$307+29%$175 – $507
Illinois IL32$307+29%$168 – $420
Kentucky KY14$290+22%$153 – $535
Virginia VA24$262+10%$261 – $524
Georgia GA18$245+3%$35 – $245
Michigan MI17$241+1%$172 – $270
Indiana IN28$218−8%$131 – $277
Mississippi MS11$214−10%$137 – $239
New Jersey NJ24$192−19%$175 – $192
Pennsylvania PA24$174−27%$117 – $376
Iowa IA14$168−29%$168 – $168
South Carolina SC18$146−39%$146 – $597
Florida FL16$142−40%$140 – $175
Texas TX53$72−70%$38 – $156
Colorado CO9not enough hospitals filed a usable price
Washington WA9not enough hospitals filed a usable price
Missouri MO7not enough hospitals filed a usable price
Arizona AZ6not enough hospitals filed a usable price
Connecticut CT6not enough hospitals filed a usable price
Massachusetts MA6not enough hospitals filed a usable price
Nevada NV6not enough hospitals filed a usable price
Tennessee TN6not enough hospitals filed a usable price
Oregon OR5not enough hospitals filed a usable price
Arkansas AR4not enough hospitals filed a usable price
Louisiana LA4not enough hospitals filed a usable price
North Dakota ND4not enough hospitals filed a usable price
Wyoming WY4not enough hospitals filed a usable price
Alabama AL3not enough hospitals filed a usable price
Hawaii HI3not enough hospitals filed a usable price
Nebraska NE3not enough hospitals filed a usable price
Alaska AK2not enough hospitals filed a usable price
North Carolina NC2not enough hospitals filed a usable price
New Mexico NM2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
West Virginia WV2not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price
Idaho ID1not enough hospitals filed a usable price
Kansas KS1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price
Utah UT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $238.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care459$207$122 – $535
Children’s14fewer than 20 hospitals
Critical access101$290$156 – $540
Ownership
For-profit36$174$38 – $347
Government69$191$137 – $377
Non-profit469$241$123 – $540
System affiliation
Part of a system519$241$126 – $540
Independent58$193$83 – $338

Cash price vs list price

Median list price (chargemaster)$524
Median cash price$238
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

411 hospitals filed a usable inpatient cash price for this code. The median is $253 and the average of the middle 60% is $294; most fall between $120 and $549.

Cash price percentiles, inpatient, across 411 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$72$123$253$529$784

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($72 vs $784).

Of the 467 hospitals that filed this code inpatient, 411 gave a usable cash price; 37 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 19 a list price only.

How complete is this

577 of the 3,956 hospitals with a price file in our corpus (15%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 653 hospitals that filed this code at all gave us
Usable cash price — counted577
Cash price carrying a plausibility flag — shown on the compare tool, excluded here55
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded20
Hospitals that filed this code653

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as Hc Cyp3A5 Gene Common Variants.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “CYP3A5 drug-processing gene test, common variants (CPT 81231) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81231-cyp3a5-drug-processing-gene-test-common-variants