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Procedure price report · Pathology

Manual gene probe test on tissue, each multi-probe set

CPT 88377the billing code this page is about

Measurement of gene or chromosome signals in a tissue sample using in situ hybridization read manually under the microscope; billed once for each multiple-probe (multiplex) stain performed.

Hospitals typically charge $354 cash for this outpatient procedure — the median across 2,476 hospitals that filed a usable cash price; the average of the middle 60% is $373. Most fall between $182 and $658 (20th–80th percentile).

Hospitals
2,476
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 2,476 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$122$203$354$580$888

The most expensive tenth of hospitals charges at least 7.3× what the cheapest tenth charges ($122 vs $888).

How the prices are spread

$89 – $116: 120 hospitals$89$116 – $151: 112 hospitals$151 – $197: 206 hospitals$151$197 – $256: 244 hospitals$256 – $333: 355 hospitals$256$333 – $434: 342 hospitals$434 – $565: 327 hospitals$434$565 – $735: 243 hospitals$735 – $956: 191 hospitals$735$956 – $1,245: 90 hospitals$956median $354price bands are equal on a log scale
Hospitals per price band (2,230 of 2,476 — the bands cover the 5th to 95th percentile)
FromToHospitals
$89$116120
$116$151112
$151$197206
$197$256244
$256$333355
$333$434342
$434$565327
$565$735243
$735$956191
$956$1,24590

Against Medicare

Medicare pays (OPPS 2026, national rate)$174
Median cash price$354
Cash as a multiple of Medicare2.0×

The Medicare figure is the national unadjusted OPPS rate for this code — what Medicare itself pays a hospital before local wage adjustment. It is a benchmark, not a price anyone is charged.

By state

The median cash price in each state, against the national median of $354.

Alaska: median $382 across 11 hospitalsAK$382Maine: median $423 across 27 hospitalsME$423Vermont: median $528 across 10 hospitalsVT$528New Hampshire: median $572 across 14 hospitalsNH$572Washington: median $339 across 55 hospitalsWA$339Idaho: median $397 across 19 hospitalsID$397Montana: median $479 across 12 hospitalsMT$479North Dakota: 8 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $458 across 83 hospitalsMN$458Illinois: median $502 across 95 hospitalsIL$502Wisconsin: median $358 across 97 hospitalsWI$358Michigan: median $176 across 60 hospitalsMI$176New York: median $344 across 82 hospitalsNY$344Massachusetts: median $532 across 42 hospitalsMA$532Oregon: median $411 across 36 hospitalsOR$411Nevada: median $372 across 13 hospitalsNV$372Wyoming: 9 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: median $1,042 across 11 hospitalsSD$1,042Iowa: median $292 across 46 hospitalsIA$292Indiana: median $278 across 79 hospitalsIN$278Ohio: median $435 across 116 hospitalsOH$435Pennsylvania: median $337 across 99 hospitalsPA$337New Jersey: median $221 across 51 hospitalsNJ$221Connecticut: median $434 across 21 hospitalsCT$434Rhode Island: 9 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $278 across 92 hospitalsCA$278Utah: median $354 across 37 hospitalsUT$354Colorado: median $376 across 50 hospitalsCO$376Nebraska: median $283 across 34 hospitalsNE$283Missouri: median $397 across 66 hospitalsMO$397Kentucky: median $415 across 42 hospitalsKY$415West Virginia: median $205 across 32 hospitalsWV$205Virginia: median $441 across 65 hospitalsVA$441Maryland: median $414 across 39 hospitalsMD$414Delaware: 7 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $605 across 31 hospitalsAZ$605New Mexico: median $189 across 23 hospitalsNM$189Kansas: median $379 across 47 hospitalsKS$379Arkansas: median $332 across 25 hospitalsAR$332Tennessee: median $200 across 72 hospitalsTN$200North Carolina: median $376 across 72 hospitalsNC$376South Carolina: median $296 across 48 hospitalsSC$296Oklahoma: median $306 across 54 hospitalsOK$306Louisiana: median $208 across 45 hospitalsLA$208Mississippi: median $153 across 44 hospitalsMS$153Alabama: median $282 across 30 hospitalsAL$282Georgia: median $353 across 80 hospitalsGA$353Hawaii: median $153 across 18 hospitalsHI$153Texas: median $304 across 181 hospitalsTX$304Florida: median $291 across 137 hospitalsFL$291
Cash price by state, most expensive first. National median $354. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
South Dakota SD11$1,042+194%$640 – $1,328
Arizona AZ31$605+71%$180 – $755
New Hampshire NH14$572+62%$371 – $1,226
Massachusetts MA42$532+50%$403 – $760
Vermont VT10$528+49%$395 – $871
Illinois IL95$502+42%$292 – $722
Montana MT12$479+35%$409 – $1,227
Minnesota MN83$458+29%$171 – $844
Virginia VA65$441+25%$106 – $650
Ohio OH116$435+23%$253 – $768
Connecticut CT21$434+22%$317 – $517
Maine ME27$423+19%$219 – $821
Kentucky KY42$415+17%$211 – $609
Maryland MD39$414+17%$180 – $739
Oregon OR36$411+16%$295 – $1,117
Idaho ID19$397+12%$308 – $801
Missouri MO66$397+12%$227 – $530
Alaska AK11$382+8%$336 – $858
Kansas KS47$379+7%$251 – $715
Colorado CO50$376+6%$329 – $573
North Carolina NC72$376+6%$284 – $730
Nevada NV13$372+5%$205 – $720
Wisconsin WI97$358+1%$256 – $677
Utah UT37$3540%$301 – $579
Georgia GA80$3530%$195 – $539
New York NY82$344−3%$203 – $687
Washington WA55$339−4%$209 – $510
Pennsylvania PA99$337−5%$181 – $637
Arkansas AR25$332−6%$137 – $385
Oklahoma OK54$306−14%$103 – $500
Texas TX181$304−14%$244 – $768
South Carolina SC48$296−16%$204 – $648
Iowa IA46$292−17%$208 – $564
Florida FL137$291−18%$123 – $652
Nebraska NE34$283−20%$166 – $645
Alabama AL30$282−20%$129 – $627
Indiana IN79$278−22%$177 – $599
California CA92$278−22%$143 – $888
New Jersey NJ51$221−38%$154 – $448
Louisiana LA45$208−41%$80 – $435
West Virginia WV32$205−42%$108 – $650
Tennessee TN72$200−43%$106 – $600
New Mexico NM23$189−47%$57 – $464
Michigan MI60$176−50%$124 – $366
Hawaii HI18$153−57%$92 – $677
Mississippi MS44$153−57%$94 – $345
Rhode Island RI9not enough hospitals filed a usable price
Wyoming WY9not enough hospitals filed a usable price
North Dakota ND8not enough hospitals filed a usable price
Delaware DE7not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $354.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,940$339$173 – $640
Children’s32$412$279 – $787
Critical access495$392$225 – $722
Ownership
For-profit369$393$192 – $821
Government363$328$176 – $643
Non-profit1,735$354$181 – $631
System affiliation
Part of a system2,113$354$181 – $660
Independent363$347$190 – $648

Cash price vs list price

Median list price (chargemaster)$621
Median cash price$354
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,745 hospitals filed a usable inpatient cash price for this code. The median is $354 and the average of the middle 60% is $374; most fall between $181 and $648.

Cash price percentiles, inpatient, across 1,745 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$118$208$354$572$883

The most expensive tenth of hospitals charges at least 7.5× what the cheapest tenth charges ($118 vs $883).

Of the 1,919 hospitals that filed this code inpatient, 1,745 gave a usable cash price; 106 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 68 a list price only.

How complete is this

2,476 of the 3,956 hospitals with a price file in our corpus (63%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 2,691 hospitals that filed this code at all gave us
Usable cash price — counted2,476
Cash price carrying a plausibility flag — shown on the compare tool, excluded here139
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded75
Hospitals that filed this code2,691

Sections not shown for this setting

  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as M/Phmtrc Alys Ish Quant/Semiq Mnl Each Multiprb|PROFESSIONAL COMPONENT.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Manual gene probe test on tissue, each multi-probe set (CPT 88377) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-88377-manual-gene-probe-test-on-tissue-each-multi-probe-set