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Procedure price report · Pathology

Manual probe count on tissue, first probe

CPT 88368the billing code this page is about

In situ hybridization with hand counting of gene or chromosome signals under a microscope; covers the first single probe stain on a specimen.

Hospitals typically charge $331 cash for this outpatient procedure — the median across 1,975 hospitals that filed a usable cash price; the average of the middle 60% is $347. Most fall between $165 and $612 (20th–80th percentile).

Hospitals
1,975
States
50
Filings dated
Mar 2023 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,975 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$104$193$331$538$921

The most expensive tenth of hospitals charges at least 8.9× what the cheapest tenth charges ($104 vs $921).

How the prices are spread

$70 – $95: 57 hospitals$70$95 – $128: 118 hospitals$128 – $174: 156 hospitals$128$174 – $237: 236 hospitals$237 – $321: 265 hospitals$237$321 – $435: 385 hospitals$435 – $591: 241 hospitals$435$591 – $802: 144 hospitals$802 – $1,088: 123 hospitals$802$1,088 – $1,476: 54 hospitals$1,088median $331price bands are equal on a log scale
Hospitals per price band (1,779 of 1,975 — the bands cover the 5th to 95th percentile)
FromToHospitals
$70$9557
$95$128118
$128$174156
$174$237236
$237$321265
$321$435385
$435$591241
$591$802144
$802$1,088123
$1,088$1,47654

Against Medicare

Medicare pays (OPPS 2026, national rate)$366
Median cash price$331
Cash as a multiple of Medicare0.90×

The Medicare figure is the national unadjusted OPPS rate for this code — what Medicare itself pays a hospital before local wage adjustment. It is a benchmark, not a price anyone is charged.

By state

The median cash price in each state, against the national median of $331.

Alaska: 7 hospitals filed a usable price — fewer than 10, so no figureAKMaine: median $164 across 20 hospitalsME$164Vermont: 7 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: median $474 across 15 hospitalsNH$474Washington: median $370 across 48 hospitalsWA$370Idaho: median $401 across 13 hospitalsID$401Montana: median $275 across 10 hospitalsMT$275North Dakota: 5 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $260 across 43 hospitalsMN$260Illinois: median $454 across 74 hospitalsIL$454Wisconsin: median $358 across 63 hospitalsWI$358Michigan: median $288 across 61 hospitalsMI$288New York: median $426 across 72 hospitalsNY$426Massachusetts: median $522 across 32 hospitalsMA$522Oregon: median $400 across 31 hospitalsOR$400Nevada: median $389 across 12 hospitalsNV$389Wyoming: median $426 across 10 hospitalsWY$426South Dakota: 8 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $329 across 29 hospitalsIA$329Indiana: median $348 across 80 hospitalsIN$348Ohio: median $460 across 98 hospitalsOH$460Pennsylvania: median $426 across 98 hospitalsPA$426New Jersey: median $398 across 38 hospitalsNJ$398Connecticut: median $392 across 14 hospitalsCT$392Rhode Island: 5 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $198 across 99 hospitalsCA$198Utah: median $2,031 across 35 hospitalsUT$2,031Colorado: median $375 across 35 hospitalsCO$375Nebraska: median $391 across 20 hospitalsNE$391Missouri: median $329 across 42 hospitalsMO$329Kentucky: median $235 across 38 hospitalsKY$235West Virginia: median $188 across 21 hospitalsWV$188Virginia: median $498 across 51 hospitalsVA$498Maryland: median $277 across 26 hospitalsMD$277Delaware: 5 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $440 across 31 hospitalsAZ$440New Mexico: 6 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $278 across 29 hospitalsKS$278Arkansas: median $277 across 20 hospitalsAR$277Tennessee: median $180 across 60 hospitalsTN$180North Carolina: median $386 across 59 hospitalsNC$386South Carolina: median $324 across 31 hospitalsSC$324Oklahoma: median $279 across 41 hospitalsOK$279Louisiana: median $216 across 41 hospitalsLA$216Mississippi: median $118 across 26 hospitalsMS$118Alabama: median $319 across 26 hospitalsAL$319Georgia: median $312 across 71 hospitalsGA$312Hawaii: median $357 across 13 hospitalsHI$357Texas: median $318 across 150 hospitalsTX$318Florida: median $222 across 106 hospitalsFL$222
Cash price by state, most expensive first. National median $331. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT35$2,031+514%$436 – $2,389
Massachusetts MA32$522+58%$340 – $715
Virginia VA51$498+51%$235 – $687
New Hampshire NH15$474+43%$199 – $833
Ohio OH98$460+39%$219 – $715
Illinois IL74$454+37%$267 – $746
Arizona AZ31$440+33%$282 – $511
Pennsylvania PA98$426+29%$225 – $818
Wyoming WY10$426+29%$300 – $574
New York NY72$426+29%$145 – $921
Idaho ID13$401+21%$252 – $1,587
Oregon OR31$400+21%$168 – $540
New Jersey NJ38$398+20%$194 – $480
Connecticut CT14$392+19%$277 – $1,195
Nebraska NE20$391+18%$110 – $524
Nevada NV12$389+18%$133 – $1,511
North Carolina NC59$386+17%$224 – $545
Colorado CO35$375+13%$285 – $692
Washington WA48$370+12%$234 – $507
Wisconsin WI63$358+8%$204 – $549
Hawaii HI13$357+8%$53 – $460
Indiana IN80$348+5%$144 – $610
Missouri MO42$3290%$204 – $517
Iowa IA29$329−1%$282 – $391
South Carolina SC31$324−2%$107 – $577
Alabama AL26$319−4%$159 – $534
Texas TX150$318−4%$193 – $428
Georgia GA71$312−6%$149 – $562
Michigan MI61$288−13%$118 – $432
Oklahoma OK41$279−16%$96 – $691
Kansas KS29$278−16%$157 – $901
Arkansas AR20$277−16%$57 – $412
Maryland MD26$277−16%$204 – $378
Montana MT10$275−17%$193 – $546
Minnesota MN43$260−21%$184 – $381
Kentucky KY38$235−29%$117 – $512
Florida FL106$222−33%$127 – $491
Louisiana LA41$216−35%$118 – $403
California CA99$198−40%$95 – $829
West Virginia WV21$188−43%$159 – $249
Tennessee TN60$180−46%$99 – $448
Maine ME20$164−51%$135 – $221
Mississippi MS26$118−64%$71 – $222
South Dakota SD8not enough hospitals filed a usable price
Alaska AK7not enough hospitals filed a usable price
Vermont VT7not enough hospitals filed a usable price
New Mexico NM6not enough hospitals filed a usable price
Delaware DE5not enough hospitals filed a usable price
North Dakota ND5not enough hospitals filed a usable price
Rhode Island RI5not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $331.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,596$333$162 – $631
Children’s32$385$216 – $608
Critical access339$318$168 – $579
Ownership
For-profit320$378$169 – $873
Government279$312$134 – $504
Non-profit1,368$329$169 – $596
System affiliation
Part of a system1,690$330$168 – $653
Independent285$331$140 – $531

Cash price vs list price

Median list price (chargemaster)$551
Median cash price$331
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,393 hospitals filed a usable inpatient cash price for this code. The median is $329 and the average of the middle 60% is $352; most fall between $166 and $650.

Cash price percentiles, inpatient, across 1,393 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$106$193$329$552$929

The most expensive tenth of hospitals charges at least 8.8× what the cheapest tenth charges ($106 vs $929).

Of the 1,550 hospitals that filed this code inpatient, 1,393 gave a usable cash price; 92 carried a plausibility flag, 1 filed a number their own filing marks as not a price, 0 gave an estimate, and 64 a list price only.

How complete is this

1,975 of the 3,956 hospitals with a price file in our corpus (50%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 2,155 hospitals that filed this code at all gave us
Usable cash price — counted1,975
Cash price carrying a plausibility flag — shown on the compare tool, excluded here109
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded3
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded68
Hospitals that filed this code2,155

Sections not shown for this setting

  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as M/Phmtrc Alys in Situ Hybridization Ea Probe Mnl|PROFESSIONAL COMPONENT.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Manual probe count on tissue, first probe (CPT 88368) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-88368-manual-probe-count-on-tissue-first-probe