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Procedure price report · Pathology

Probe test on tissue using a multi-target probe set

CPT 88366the billing code this page is about

In situ hybridization that uses several labeled probes on one tissue slide at the same time; billed once for each multiplex probe stain performed.

Hospitals typically charge $378 cash for this outpatient procedure — the median across 1,014 hospitals that filed a usable cash price; the average of the middle 60% is $412. Most fall between $202 and $785 (20th–80th percentile).

Hospitals
1,014
States
49
Filings dated
Nov 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,014 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$134$213$378$644$1,042

The most expensive tenth of hospitals charges at least 7.8× what the cheapest tenth charges ($134 vs $1,042).

How the prices are spread

$82 – $109: 35 hospitals$82$109 – $144: 33 hospitals$144 – $190: 63 hospitals$144$190 – $251: 115 hospitals$251 – $333: 138 hospitals$251$333 – $440: 152 hospitals$440 – $583: 152 hospitals$440$583 – $771: 74 hospitals$771 – $1,020: 87 hospitals$771$1,020 – $1,350: 71 hospitals$1,020median $378price bands are equal on a log scale
Hospitals per price band (920 of 1,014 — the bands cover the 5th to 95th percentile)
FromToHospitals
$82$10935
$109$14433
$144$19063
$190$251115
$251$333138
$333$440152
$440$583152
$583$77174
$771$1,02087
$1,020$1,35071

Against Medicare

Medicare pays (OPPS 2026, national rate)$174
Median cash price$378
Cash as a multiple of Medicare2.2×

The Medicare figure is the national unadjusted OPPS rate for this code — what Medicare itself pays a hospital before local wage adjustment. It is a benchmark, not a price anyone is charged.

By state

The median cash price in each state, against the national median of $378.

Alaska: 2 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 3 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 2 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 4 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $339 across 24 hospitalsWA$339Idaho: median $500 across 12 hospitalsID$500Montana: no hospital in the corpus filed a usable priceMTNorth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $408 across 39 hospitalsMN$408Illinois: median $586 across 48 hospitalsIL$586Wisconsin: median $602 across 66 hospitalsWI$602Michigan: median $297 across 33 hospitalsMI$297New York: median $213 across 33 hospitalsNY$213Massachusetts: median $522 across 12 hospitalsMA$522Oregon: median $468 across 17 hospitalsOR$468Nevada: 3 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 3 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $292 across 15 hospitalsIA$292Indiana: median $402 across 30 hospitalsIN$402Ohio: median $569 across 70 hospitalsOH$569Pennsylvania: median $266 across 51 hospitalsPA$266New Jersey: median $202 across 22 hospitalsNJ$202Connecticut: 5 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 3 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $552 across 55 hospitalsCA$552Utah: median $1,350 across 33 hospitalsUT$1,350Colorado: median $364 across 24 hospitalsCO$364Nebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $484 across 22 hospitalsMO$484Kentucky: median $422 across 18 hospitalsKY$422West Virginia: 7 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $319 across 29 hospitalsVA$319Maryland: median $420 across 24 hospitalsMD$420Delaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: median $1,042 across 21 hospitalsAZ$1,042New Mexico: 2 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 7 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 5 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $189 across 25 hospitalsTN$189North Carolina: median $356 across 25 hospitalsNC$356South Carolina: median $332 across 22 hospitalsSC$332Oklahoma: median $209 across 25 hospitalsOK$209Louisiana: 6 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: 3 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 8 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $215 across 21 hospitalsGA$215Hawaii: median $357 across 13 hospitalsHI$357Texas: median $205 across 63 hospitalsTX$205Florida: median $310 across 52 hospitalsFL$310
Cash price by state, most expensive first. National median $378. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT33$1,350+258%$436 – $1,588
Arizona AZ21$1,042+176%$181 – $1,042
Wisconsin WI66$602+60%$323 – $1,030
Illinois IL48$586+55%$292 – $880
Ohio OH70$569+51%$352 – $872
California CA55$552+46%$347 – $829
Massachusetts MA12$522+38%$354 – $1,876
Idaho ID12$500+32%$365 – $515
Missouri MO22$484+28%$325 – $587
Oregon OR17$468+24%$328 – $482
Kentucky KY18$422+12%$242 – $469
Maryland MD24$420+11%$313 – $519
Minnesota MN39$408+8%$171 – $526
Indiana IN30$402+6%$319 – $533
Colorado CO24$364−4%$190 – $518
Hawaii HI13$357−5%$99 – $974
North Carolina NC25$356−6%$260 – $598
Washington WA24$339−10%$297 – $622
South Carolina SC22$332−12%$279 – $573
Virginia VA29$319−16%$234 – $481
Florida FL52$310−18%$168 – $821
Michigan MI33$297−21%$69 – $324
Iowa IA15$292−23%$292 – $292
Pennsylvania PA51$266−30%$89 – $927
Georgia GA21$215−43%$212 – $361
New York NY33$213−44%$203 – $436
Oklahoma OK25$209−45%$101 – $550
Texas TX63$205−46%$75 – $375
New Jersey NJ22$202−47%$190 – $626
Tennessee TN25$189−50%$100 – $215
Alabama AL8not enough hospitals filed a usable price
Kansas KS7not enough hospitals filed a usable price
West Virginia WV7not enough hospitals filed a usable price
Louisiana LA6not enough hospitals filed a usable price
Arkansas AR5not enough hospitals filed a usable price
Connecticut CT5not enough hospitals filed a usable price
New Hampshire NH4not enough hospitals filed a usable price
Maine ME3not enough hospitals filed a usable price
Mississippi MS3not enough hospitals filed a usable price
Nevada NV3not enough hospitals filed a usable price
Rhode Island RI3not enough hospitals filed a usable price
Wyoming WY3not enough hospitals filed a usable price
Alaska AK2not enough hospitals filed a usable price
North Dakota ND2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
New Mexico NM2not enough hospitals filed a usable price
South Dakota SD2not enough hospitals filed a usable price
Vermont VT2not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $378.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care872$364$194 – $768
Children’s17fewer than 20 hospitals
Critical access120$483$308 – $1,014
Ownership
For-profit108$361$156 – $1,042
Government96$310$203 – $562
Non-profit805$402$205 – $785
System affiliation
Part of a system917$388$202 – $785
Independent97$365$203 – $715

Cash price vs list price

Median list price (chargemaster)$681
Median cash price$378
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

759 hospitals filed a usable inpatient cash price for this code. The median is $425 and the average of the middle 60% is $463; most fall between $211 and $829.

Cash price percentiles, inpatient, across 759 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$144$254$425$762$1,042

The most expensive tenth of hospitals charges at least 7.3× what the cheapest tenth charges ($144 vs $1,042).

Of the 824 hospitals that filed this code inpatient, 759 gave a usable cash price; 47 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 18 a list price only.

How complete is this

1,014 of the 3,956 hospitals with a price file in our corpus (26%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,095 hospitals that filed this code at all gave us
Usable cash price — counted1,014
Cash price carrying a plausibility flag — shown on the compare tool, excluded here57
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded22
Hospitals that filed this code1,095

Sections not shown for this setting

  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as INSITU HYBRIDIZATION (FISH).

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Probe test on tissue using a multi-target probe set (CPT 88366) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-88366-probe-test-on-tissue-using-a-multi-target-probe-set