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Procedure price report · Pathology

Probe test on tissue for one target, first probe

CPT 88365the billing code this page is about

In situ hybridization, in which a labeled probe binds a specific genetic sequence in a tissue sample; covers the first single probe stain on the specimen.

Hospitals typically charge $245 cash for this outpatient procedure — the median across 2,761 hospitals that filed a usable cash price; the average of the middle 60% is $258. Most fall between $128 and $442 (20th–80th percentile).

Hospitals
2,761
States
50
Filings dated
Dec 2023 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 2,761 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$79$142$245$399$662

The most expensive tenth of hospitals charges at least 8.3× what the cheapest tenth charges ($79 vs $662).

How the prices are spread

$55 – $73: 103 hospitals$55$73 – $98: 110 hospitals$98 – $130: 215 hospitals$98$130 – $174: 353 hospitals$174 – $232: 398 hospitals$174$232 – $309: 391 hospitals$309 – $413: 397 hospitals$309$413 – $550: 281 hospitals$550 – $734: 171 hospitals$550$734 – $979: 66 hospitals$734median $245price bands are equal on a log scale
Hospitals per price band (2,485 of 2,761 — the bands cover the 5th to 95th percentile)
FromToHospitals
$55$73103
$73$98110
$98$130215
$130$174353
$174$232398
$232$309391
$309$413397
$413$550281
$550$734171
$734$97966

Against Medicare

Medicare pays (OPPS 2026, national rate)$174
Median cash price$245
Cash as a multiple of Medicare1.41×

The Medicare figure is the national unadjusted OPPS rate for this code — what Medicare itself pays a hospital before local wage adjustment. It is a benchmark, not a price anyone is charged.

By state

The median cash price in each state, against the national median of $245.

Alaska: median $188 across 11 hospitalsAK$188Maine: median $148 across 27 hospitalsME$148Vermont: median $265 across 13 hospitalsVT$265New Hampshire: median $446 across 17 hospitalsNH$446Washington: median $283 across 58 hospitalsWA$283Idaho: median $273 across 19 hospitalsID$273Montana: median $289 across 16 hospitalsMT$289North Dakota: median $338 across 17 hospitalsND$338Minnesota: median $294 across 87 hospitalsMN$294Illinois: median $325 across 112 hospitalsIL$325Wisconsin: median $344 across 94 hospitalsWI$344Michigan: median $173 across 88 hospitalsMI$173New York: median $308 across 92 hospitalsNY$308Massachusetts: median $367 across 48 hospitalsMA$367Oregon: median $279 across 43 hospitalsOR$279Nevada: median $199 across 11 hospitalsNV$199Wyoming: median $272 across 12 hospitalsWY$272South Dakota: median $407 across 16 hospitalsSD$407Iowa: median $292 across 59 hospitalsIA$292Indiana: median $226 across 90 hospitalsIN$226Ohio: median $271 across 128 hospitalsOH$271Pennsylvania: median $240 across 116 hospitalsPA$240New Jersey: median $202 across 47 hospitalsNJ$202Connecticut: median $229 across 22 hospitalsCT$229Rhode Island: median $190 across 10 hospitalsRI$190California: median $154 across 142 hospitalsCA$154Utah: median $1,189 across 35 hospitalsUT$1,189Colorado: median $363 across 56 hospitalsCO$363Nebraska: median $265 across 53 hospitalsNE$265Missouri: median $215 across 67 hospitalsMO$215Kentucky: median $169 across 57 hospitalsKY$169West Virginia: median $166 across 30 hospitalsWV$166Virginia: median $225 across 68 hospitalsVA$225Maryland: median $226 across 40 hospitalsMD$226Delaware: 6 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $217 across 34 hospitalsAZ$217New Mexico: median $173 across 19 hospitalsNM$173Kansas: median $285 across 49 hospitalsKS$285Arkansas: median $146 across 26 hospitalsAR$146Tennessee: median $135 across 77 hospitalsTN$135North Carolina: median $275 across 79 hospitalsNC$275South Carolina: median $289 across 49 hospitalsSC$289Oklahoma: median $164 across 53 hospitalsOK$164Louisiana: median $107 across 46 hospitalsLA$107Mississippi: median $77 across 40 hospitalsMS$77Alabama: median $210 across 36 hospitalsAL$210Georgia: median $235 across 80 hospitalsGA$235Hawaii: median $265 across 17 hospitalsHI$265Texas: median $324 across 202 hospitalsTX$324Florida: median $142 across 147 hospitalsFL$142
Cash price by state, most expensive first. National median $245. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT35$1,189+386%$305 – $1,399
New Hampshire NH17$446+82%$149 – $1,107
South Dakota SD16$407+66%$386 – $475
Massachusetts MA48$367+50%$261 – $519
Colorado CO56$363+48%$190 – $708
Wisconsin WI94$344+40%$214 – $529
North Dakota ND17$338+38%$258 – $403
Illinois IL112$325+33%$191 – $575
Texas TX202$324+32%$162 – $575
New York NY92$308+26%$179 – $510
Minnesota MN87$294+20%$114 – $371
Iowa IA59$292+19%$141 – $369
South Carolina SC49$289+18%$150 – $294
Montana MT16$289+18%$151 – $409
Kansas KS49$285+17%$142 – $555
Washington WA58$283+16%$155 – $441
Oregon OR43$279+14%$168 – $344
North Carolina NC79$275+12%$123 – $437
Idaho ID19$273+12%$185 – $494
Wyoming WY12$272+11%$176 – $496
Ohio OH128$271+11%$160 – $437
Vermont VT13$265+8%$110 – $581
Nebraska NE53$265+8%$148 – $367
Hawaii HI17$265+8%$191 – $442
Pennsylvania PA116$240−2%$110 – $460
Georgia GA80$235−4%$110 – $312
Connecticut CT22$229−6%$216 – $490
Maryland MD40$226−8%$165 – $603
Indiana IN90$226−8%$123 – $458
Virginia VA68$225−8%$139 – $352
Arizona AZ34$217−11%$149 – $696
Missouri MO67$215−12%$101 – $285
Alabama AL36$210−14%$139 – $602
New Jersey NJ47$202−18%$133 – $370
Nevada NV11$199−19%$91 – $720
Rhode Island RI10$190−22%$135 – $311
Alaska AK11$188−23%$142 – $223
New Mexico NM19$173−29%$97 – $490
Michigan MI88$173−29%$128 – $320
Kentucky KY57$169−31%$110 – $283
West Virginia WV30$166−32%$39 – $345
Oklahoma OK53$164−33%$46 – $280
California CA142$154−37%$77 – $512
Maine ME27$148−40%$106 – $345
Arkansas AR26$146−40%$81 – $245
Florida FL147$142−42%$89 – $375
Tennessee TN77$135−45%$102 – $319
Louisiana LA46$107−56%$61 – $233
Mississippi MS40$77−69%$63 – $152
Delaware DE6not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $245.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care2,125$232$123 – $446
Children’s50$275$146 – $464
Critical access577$281$144 – $437
Ownership
For-profit410$275$126 – $696
Government405$213$117 – $375
Non-profit1,937$248$131 – $437
System affiliation
Part of a system2,330$256$130 – $450
Independent431$217$113 – $407

Cash price vs list price

Median list price (chargemaster)$418
Median cash price$245
Cash as a share of list, median hospital64%

At the typical hospital, asking for the cash price cuts the list price by about 36%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,950 hospitals filed a usable inpatient cash price for this code. The median is $266 and the average of the middle 60% is $266; most fall between $133 and $455.

Cash price percentiles, inpatient, across 1,950 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$91$145$266$413$628

The most expensive tenth of hospitals charges at least 6.9× what the cheapest tenth charges ($91 vs $628).

Of the 2,147 hospitals that filed this code inpatient, 1,950 gave a usable cash price; 114 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 83 a list price only.

How complete is this

2,761 of the 3,956 hospitals with a price file in our corpus (70%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 2,992 hospitals that filed this code at all gave us
Usable cash price — counted2,761
Cash price carrying a plausibility flag — shown on the compare tool, excluded here139
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded91
Hospitals that filed this code2,992

Sections not shown for this setting

  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as In Situ Hybridization 1st Probe Stain|PROFESSIONAL COMPONENT.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Probe test on tissue for one target, first probe (CPT 88365) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-88365-probe-test-on-tissue-for-one-target-first-probe