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Procedure price report · Pathology

Breast cancer 21-gene recurrence risk test

CPT 81519the billing code this page is about

A laboratory test that measures the activity of 21 genes in breast tumor tissue and reports a score related to the chance of cancer returning.

Hospitals typically charge $4,380 cash for this outpatient procedure — the median across 372 hospitals that filed a usable cash price; the average of the middle 60% is $4,615. Most fall between $2,589 and $7,757 (20th–80th percentile).

Hospitals
372
States
40
Filings dated
Jun 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 372 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$2,227$2,855$4,380$7,285$9,025

The most expensive tenth of hospitals charges at least 4.1× what the cheapest tenth charges ($2,227 vs $9,025).

How the prices are spread

$525 – $728: 5 hospitals$525$728 – $1,008: 0 hospitals$1,008 – $1,397: 4 hospitals$1,008$1,397 – $1,936: 5 hospitals$1,936 – $2,683: 50 hospitals$1,936$2,683 – $3,718: 45 hospitals$3,718 – $5,152: 98 hospitals$3,718$5,152 – $7,140: 51 hospitals$7,140 – $9,894: 61 hospitals$7,140$9,894 – $13,710: 17 hospitals$9,894median $4,380price bands are equal on a log scale
Hospitals per price band (336 of 372 — the bands cover the 5th to 95th percentile)
FromToHospitals
$525$7285
$728$1,0080
$1,008$1,3974
$1,397$1,9365
$1,936$2,68350
$2,683$3,71845
$3,718$5,15298
$5,152$7,14051
$7,140$9,89461
$9,894$13,71017

By state

The median cash price in each state, against the national median of $4,380.

Alaska: 3 hospitals filed a usable price — fewer than 10, so no figureAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: median $5,874 across 11 hospitalsWA$5,874Idaho: no hospital in the corpus filed a usable priceIDMontana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 1 hospital filed a usable price — fewer than 10, so no figureNDMinnesota: no hospital in the corpus filed a usable priceMNIllinois: 8 hospitals filed a usable price — fewer than 10, so no figureILWisconsin: 8 hospitals filed a usable price — fewer than 10, so no figureWIMichigan: 8 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $3,873 across 19 hospitalsNY$3,873Massachusetts: 4 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 5 hospitals filed a usable price — fewer than 10, so no figureORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $3,718 across 16 hospitalsIA$3,718Indiana: median $4,870 across 18 hospitalsIN$4,870Ohio: 9 hospitals filed a usable price — fewer than 10, so no figureOHPennsylvania: 8 hospitals filed a usable price — fewer than 10, so no figurePANew Jersey: median $4,260 across 29 hospitalsNJ$4,260Connecticut: 5 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $8,854 across 23 hospitalsCA$8,854Utah: 2 hospitals filed a usable price — fewer than 10, so no figureUTColorado: 8 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 8 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: median $14,098 across 11 hospitalsKY$14,098West Virginia: no hospital in the corpus filed a usable priceWVVirginia: median $2,607 across 24 hospitalsVA$2,607Maryland: median $5,508 across 13 hospitalsMD$5,508Delaware: no hospital in the corpus filed a usable priceDEArizona: 4 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 5 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 5 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 2 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $4,326 across 14 hospitalsTN$4,326North Carolina: 9 hospitals filed a usable price — fewer than 10, so no figureNCSouth Carolina: 2 hospitals filed a usable price — fewer than 10, so no figureSCOklahoma: 3 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 3 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: median $2,417 across 18 hospitalsMS$2,417Alabama: 2 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $4,468 across 12 hospitalsGA$4,468Hawaii: 2 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $504 across 25 hospitalsTX$504Florida: median $3,182 across 22 hospitalsFL$3,182
Cash price by state, most expensive first. National median $4,380. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Kentucky KY11$14,098+222%$4,808 – $14,098
California CA23$8,854+102%$8,854 – $8,854
Washington WA11$5,874+34%$5,874 – $9,424
Maryland MD13$5,508+26%$4,848 – $6,738
Indiana IN18$4,870+11%$3,486 – $6,582
Georgia GA12$4,468+2%$3,199 – $4,925
Tennessee TN14$4,326−1%$2,779 – $4,388
New Jersey NJ29$4,260−3%$3,873 – $7,567
New York NY19$3,873−12%$3,873 – $4,648
Iowa IA16$3,718−15%$3,003 – $3,718
Florida FL22$3,182−27%$2,589 – $7,334
Virginia VA24$2,607−40%$2,318 – $9,025
Mississippi MS18$2,417−45%$1,575 – $4,954
Texas TX25$504−88%$504 – $2,855
North Carolina NC9not enough hospitals filed a usable price
Ohio OH9not enough hospitals filed a usable price
Colorado CO8not enough hospitals filed a usable price
Illinois IL8not enough hospitals filed a usable price
Michigan MI8not enough hospitals filed a usable price
Missouri MO8not enough hospitals filed a usable price
Pennsylvania PA8not enough hospitals filed a usable price
Wisconsin WI8not enough hospitals filed a usable price
Connecticut CT5not enough hospitals filed a usable price
Kansas KS5not enough hospitals filed a usable price
New Mexico NM5not enough hospitals filed a usable price
Oregon OR5not enough hospitals filed a usable price
Arizona AZ4not enough hospitals filed a usable price
Massachusetts MA4not enough hospitals filed a usable price
Alaska AK3not enough hospitals filed a usable price
Louisiana LA3not enough hospitals filed a usable price
Oklahoma OK3not enough hospitals filed a usable price
Alabama AL2not enough hospitals filed a usable price
Arkansas AR2not enough hospitals filed a usable price
Hawaii HI2not enough hospitals filed a usable price
South Carolina SC2not enough hospitals filed a usable price
Utah UT2not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
North Dakota ND1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $4,380.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care332$4,264$2,589 – $8,098
Children’s4fewer than 20 hospitals
Critical access35$5,383$3,089 – $7,285
Ownership
For-profit29$5,383$2,308 – $11,619
Government39$3,873$2,229 – $7,675
Non-profit303$4,388$2,607 – $7,685
System affiliation
Part of a system333$4,380$2,589 – $8,098
Independent39$4,394$2,310 – $6,416

Cash price vs list price

Median list price (chargemaster)$8,175
Median cash price$4,380
Cash as a share of list, median hospital56%

At the typical hospital, asking for the cash price cuts the list price by about 44%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

256 hospitals filed a usable inpatient cash price for this code. The median is $3,718 and the average of the middle 60% is $4,165; most fall between $2,318 and $7,334.

Cash price percentiles, inpatient, across 256 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,651$2,589$3,718$6,416$8,854

The most expensive tenth of hospitals charges at least 5.4× what the cheapest tenth charges ($1,651 vs $8,854).

Of the 281 hospitals that filed this code inpatient, 256 gave a usable cash price; 10 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 15 a list price only.

How complete is this

372 of the 3,956 hospitals with a price file in our corpus (9%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 404 hospitals that filed this code at all gave us
Usable cash price — counted372
Cash price carrying a plausibility flag — shown on the compare tool, excluded here15
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded15
Hospitals that filed this code404

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as ONCOLOGY BREAST MRNA.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Breast cancer 21-gene recurrence risk test (CPT 81519) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81519-breast-cancer-21-gene-recurrence-risk-test