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Procedure price report · Pathology

First trimester prenatal screen, two blood proteins

CPT 81508the billing code this page is about

Blood test during pregnancy measuring two proteins and reporting a risk estimate for certain fetal chromosome and structural conditions.

Hospitals typically charge $110 cash for this outpatient procedure — the median across 556 hospitals that filed a usable cash price; the average of the middle 60% is $116. Most fall between $57 and $223 (20th–80th percentile).

Hospitals
556
States
46
Filings dated
Aug 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 556 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$39$62$110$183$306

The most expensive tenth of hospitals charges at least 7.9× what the cheapest tenth charges ($39 vs $306).

How the prices are spread

$31 – $41: 30 hospitals$31$41 – $55: 51 hospitals$55 – $74: 76 hospitals$55$74 – $99: 55 hospitals$99 – $132: 87 hospitals$99$132 – $176: 84 hospitals$176 – $234: 44 hospitals$176$234 – $313: 48 hospitals$313 – $418: 13 hospitals$313$418 – $558: 15 hospitals$418median $110price bands are equal on a log scale
Hospitals per price band (503 of 556 — the bands cover the 5th to 95th percentile)
FromToHospitals
$31$4130
$41$5551
$55$7476
$74$9955
$99$13287
$132$17684
$176$23444
$234$31348
$313$41813
$418$55815

By state

The median cash price in each state, against the national median of $110.

Alaska: 4 hospitals filed a usable price — fewer than 10, so no figureAKMaine: median $122 across 15 hospitalsME$122Vermont: 2 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 7 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $55 across 20 hospitalsWA$55Idaho: 3 hospitals filed a usable price — fewer than 10, so no figureIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $70 across 27 hospitalsMN$70Illinois: median $114 across 31 hospitalsIL$114Wisconsin: median $156 across 45 hospitalsWI$156Michigan: median $75 across 22 hospitalsMI$75New York: median $95 across 53 hospitalsNY$95Massachusetts: median $211 across 20 hospitalsMA$211Oregon: median $136 across 13 hospitalsOR$136Nevada: 4 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 3 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $128 across 11 hospitalsIA$128Indiana: no hospital in the corpus filed a usable priceINOhio: median $151 across 38 hospitalsOH$151Pennsylvania: median $82 across 31 hospitalsPA$82New Jersey: median $60 across 22 hospitalsNJ$60Connecticut: 7 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 4 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $1,428 across 20 hospitalsCA$1,428Utah: 1 hospital filed a usable price — fewer than 10, so no figureUTColorado: median $167 across 16 hospitalsCO$167Nebraska: 4 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: 8 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 4 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: 8 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $30 across 16 hospitalsVA$30Maryland: 6 hospitals filed a usable price — fewer than 10, so no figureMDDelaware: no hospital in the corpus filed a usable priceDEArizona: median $183 across 10 hospitalsAZ$183New Mexico: 5 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 2 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 9 hospitals filed a usable price — fewer than 10, so no figureARTennessee: 5 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: 1 hospital filed a usable price — fewer than 10, so no figureNCSouth Carolina: 1 hospital filed a usable price — fewer than 10, so no figureSCOklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: median $85 across 17 hospitalsLA$85Mississippi: 7 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 6 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: 2 hospitals filed a usable price — fewer than 10, so no figureGAHawaii: 1 hospital filed a usable price — fewer than 10, so no figureHITexas: median $64 across 13 hospitalsTX$64Florida: 8 hospitals filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $110. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA20$1,428+1198%$1,428 – $1,428
Massachusetts MA20$211+92%$157 – $256
Arizona AZ10$183+66%$92 – $183
Colorado CO16$167+51%$112 – $272
Wisconsin WI45$156+42%$110 – $254
Ohio OH38$151+37%$104 – $173
Oregon OR13$136+24%$136 – $191
Iowa IA11$128+16%$128 – $128
Maine ME15$122+10%$58 – $223
Illinois IL31$114+4%$105 – $187
New York NY53$95−14%$54 – $243
Louisiana LA17$85−23%$60 – $144
Pennsylvania PA31$82−26%$39 – $229
Michigan MI22$75−32%$57 – $90
Minnesota MN27$70−36%$63 – $72
Texas TX13$64−42%$64 – $446
New Jersey NJ22$60−46%$54 – $60
Washington WA20$55−50%$52 – $78
Virginia VA16$30−73%$30 – $34
Arkansas AR9not enough hospitals filed a usable price
Florida FL8not enough hospitals filed a usable price
Missouri MO8not enough hospitals filed a usable price
West Virginia WV8not enough hospitals filed a usable price
Connecticut CT7not enough hospitals filed a usable price
Mississippi MS7not enough hospitals filed a usable price
New Hampshire NH7not enough hospitals filed a usable price
Alabama AL6not enough hospitals filed a usable price
Maryland MD6not enough hospitals filed a usable price
New Mexico NM5not enough hospitals filed a usable price
Tennessee TN5not enough hospitals filed a usable price
Alaska AK4not enough hospitals filed a usable price
Kentucky KY4not enough hospitals filed a usable price
Nebraska NE4not enough hospitals filed a usable price
Nevada NV4not enough hospitals filed a usable price
Rhode Island RI4not enough hospitals filed a usable price
Idaho ID3not enough hospitals filed a usable price
Wyoming WY3not enough hospitals filed a usable price
Georgia GA2not enough hospitals filed a usable price
Kansas KS2not enough hospitals filed a usable price
North Dakota ND2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Vermont VT2not enough hospitals filed a usable price
Hawaii HI1not enough hospitals filed a usable price
North Carolina NC1not enough hospitals filed a usable price
South Carolina SC1not enough hospitals filed a usable price
Utah UT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $110.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care451$105$54 – $197
Children’s7fewer than 20 hospitals
Critical access96$148$75 – $254
Ownership
For-profit29$130$64 – $215
Government49$63$41 – $167
Non-profit476$110$60 – $229
System affiliation
Part of a system501$110$55 – $223
Independent55$132$62 – $203

Cash price vs list price

Median list price (chargemaster)$184
Median cash price$110
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

423 hospitals filed a usable inpatient cash price for this code. The median is $128 and the average of the middle 60% is $139; most fall between $64 and $254.

Cash price percentiles, inpatient, across 423 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$47$70$128$235$515

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($47 vs $515).

Of the 452 hospitals that filed this code inpatient, 423 gave a usable cash price; 21 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 8 a list price only.

How complete is this

556 of the 3,956 hospitals with a price file in our corpus (14%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 583 hospitals that filed this code at all gave us
Usable cash price — counted556
Cash price carrying a plausibility flag — shown on the compare tool, excluded here23
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded3
Hospitals that filed this code583

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as FTL CGEN ABNOR TWO PROTEINS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “First trimester prenatal screen, two blood proteins (CPT 81508) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81508-first-trimester-prenatal-screen-two-blood-proteins