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Procedure price report · Pathology

Tumor gene panel, 51 or more genes, DNA and RNA

CPT 81459the billing code this page is about

Genomic sequencing of a solid tumor sample that examines at least 51 genes in both DNA and RNA for mutations, extra or missing copies, and gene rearrangements.

Hospitals typically charge $2,990 cash for this outpatient procedure — the median across 371 hospitals that filed a usable cash price; the average of the middle 60% is $3,069. Most fall between $1,658 and $6,137 (20th–80th percentile).

Hospitals
371
States
34
Filings dated
Dec 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 371 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$913$1,908$2,990$4,484$9,283

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($913 vs $9,283).

How the prices are spread

$823 – $1,055: 28 hospitals$823$1,055 – $1,352: 7 hospitals$1,352 – $1,734: 39 hospitals$1,352$1,734 – $2,222: 22 hospitals$2,222 – $2,848: 39 hospitals$2,222$2,848 – $3,651: 101 hospitals$3,651 – $4,680: 33 hospitals$3,651$4,680 – $5,998: 13 hospitals$5,998 – $7,689: 18 hospitals$5,998$7,689 – $9,855: 46 hospitals$7,689median $2,990price bands are equal on a log scale
Hospitals per price band (346 of 371 — the bands cover the 5th to 95th percentile)
FromToHospitals
$823$1,05528
$1,055$1,3527
$1,352$1,73439
$1,734$2,22222
$2,222$2,84839
$2,848$3,651101
$3,651$4,68033
$4,680$5,99813
$5,998$7,68918
$7,689$9,85546

By state

The median cash price in each state, against the national median of $2,990.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: 2 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 4 hospitals filed a usable price — fewer than 10, so no figureNHWashington: 4 hospitals filed a usable price — fewer than 10, so no figureWAIdaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: median $3,168 across 17 hospitalsMN$3,168Illinois: 8 hospitals filed a usable price — fewer than 10, so no figureILWisconsin: median $3,413 across 22 hospitalsWI$3,413Michigan: 8 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $3,587 across 35 hospitalsNY$3,587Massachusetts: median $9,283 across 13 hospitalsMA$9,283Oregon: no hospital in the corpus filed a usable priceORNevada: no hospital in the corpus filed a usable priceNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $2,870 across 13 hospitalsIA$2,870Indiana: median $2,176 across 14 hospitalsIN$2,176Ohio: median $9,360 across 22 hospitalsOH$9,360Pennsylvania: median $761 across 15 hospitalsPA$761New Jersey: median $2,990 across 19 hospitalsNJ$2,990Connecticut: no hospital in the corpus filed a usable priceCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $2,981 across 20 hospitalsCA$2,981Utah: no hospital in the corpus filed a usable priceUTColorado: median $823 across 11 hospitalsCO$823Nebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: 3 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 7 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: no hospital in the corpus filed a usable priceWVVirginia: median $2,296 across 23 hospitalsVA$2,296Maryland: 6 hospitals filed a usable price — fewer than 10, so no figureMDDelaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: 2 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: 4 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 1 hospital filed a usable price — fewer than 10, so no figureARTennessee: 9 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: no hospital in the corpus filed a usable priceNCSouth Carolina: 1 hospital filed a usable price — fewer than 10, so no figureSCOklahoma: 7 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 4 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: 1 hospital filed a usable price — fewer than 10, so no figureMSAlabama: 2 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $1,658 across 18 hospitalsGA$1,658Hawaii: no hospital in the corpus filed a usable priceHITexas: median $2,715 across 41 hospitalsTX$2,715Florida: median $3,600 across 12 hospitalsFL$3,600
Cash price by state, most expensive first. National median $2,990. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Ohio OH22$9,360+213%$8,772 – $9,360
Massachusetts MA13$9,283+211%$1,620 – $9,283
Florida FL12$3,600+20%$2,990 – $3,600
New York NY35$3,587+20%$2,990 – $5,621
Wisconsin WI22$3,413+14%$3,240 – $7,105
Minnesota MN17$3,168+6%$1,752 – $3,168
New Jersey NJ19$2,9900%$2,036 – $3,438
California CA20$2,9810%$2,981 – $2,981
Iowa IA13$2,870−4%$2,870 – $2,870
Texas TX41$2,715−9%$913 – $3,402
Virginia VA23$2,296−23%$1,359 – $3,954
Indiana IN14$2,176−27%$1,676 – $2,719
Georgia GA18$1,658−45%$1,658 – $1,658
Colorado CO11$823−72%$823 – $823
Pennsylvania PA15$761−75%$571 – $6,438
Tennessee TN9not enough hospitals filed a usable price
Illinois IL8not enough hospitals filed a usable price
Michigan MI8not enough hospitals filed a usable price
Kentucky KY7not enough hospitals filed a usable price
Oklahoma OK7not enough hospitals filed a usable price
Maryland MD6not enough hospitals filed a usable price
Kansas KS4not enough hospitals filed a usable price
Louisiana LA4not enough hospitals filed a usable price
New Hampshire NH4not enough hospitals filed a usable price
Washington WA4not enough hospitals filed a usable price
Missouri MO3not enough hospitals filed a usable price
Alabama AL2not enough hospitals filed a usable price
Arizona AZ2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
Vermont VT2not enough hospitals filed a usable price
Arkansas AR1not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price
Mississippi MS1not enough hospitals filed a usable price
South Carolina SC1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $2,990.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care325$2,990$1,658 – $5,355
Children’s1fewer than 20 hospitals
Critical access42$2,870$1,429 – $7,105
Ownership
For-profit29$2,715$1,429 – $3,740
Government39$2,990$1,429 – $4,484
Non-profit300$2,990$1,676 – $6,495
System affiliation
Part of a system349$2,981$1,658 – $5,687
Independent22$3,528$2,590 – $7,603

Cash price vs list price

Median list price (chargemaster)$5,324
Median cash price$2,990
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

286 hospitals filed a usable inpatient cash price for this code. The median is $2,870 and the average of the middle 60% is $2,870; most fall between $1,658 and $4,972.

Cash price percentiles, inpatient, across 286 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$913$1,658$2,870$4,016$9,283

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($913 vs $9,283).

Of the 303 hospitals that filed this code inpatient, 286 gave a usable cash price; 10 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 7 a list price only.

How complete is this

371 of the 3,956 hospitals with a price file in our corpus (9%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 384 hospitals that filed this code at all gave us
Usable cash price — counted371
Cash price carrying a plausibility flag — shown on the compare tool, excluded here4
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded7
Hospitals that filed this code384

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as SO NEO GSAP DNA/DNA&RNA.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Tumor gene panel, 51 or more genes, DNA and RNA (CPT 81459) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81459-tumor-gene-panel-51-or-more-genes-dna-and-rna