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Procedure price report · Pathology

Cancer gene panel, 51 or more genes, RNA testing

CPT 81456the billing code this page is about

A large laboratory panel on solid tumor or blood cancer tissue that analyzes RNA from 51 or more genes, mainly to detect gene fusions and rearrangements; billed once for the panel.

Hospitals typically charge $3,371 cash for this outpatient procedure — the median across 643 hospitals that filed a usable cash price; the average of the middle 60% is $3,495. Most fall between $2,117 and $5,447 (20th–80th percentile).

Hospitals
643
States
42
Filings dated
Dec 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 643 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,314$2,274$3,371$4,745$7,058

The most expensive tenth of hospitals charges at least 5.4× what the cheapest tenth charges ($1,314 vs $7,058).

How the prices are spread

$966 – $1,207: 31 hospitals$966$1,207 – $1,508: 16 hospitals$1,508 – $1,885: 24 hospitals$1,508$1,885 – $2,356: 70 hospitals$2,356 – $2,944: 91 hospitals$2,356$2,944 – $3,679: 118 hospitals$3,679 – $4,598: 77 hospitals$3,679$4,598 – $5,745: 66 hospitals$5,745 – $7,180: 57 hospitals$5,745$7,180 – $8,973: 30 hospitals$7,180median $3,371price bands are equal on a log scale
Hospitals per price band (580 of 643 — the bands cover the 5th to 95th percentile)
FromToHospitals
$966$1,20731
$1,207$1,50816
$1,508$1,88524
$1,885$2,35670
$2,356$2,94491
$2,944$3,679118
$3,679$4,59877
$4,598$5,74566
$5,745$7,18057
$7,180$8,97330

By state

The median cash price in each state, against the national median of $3,371.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: 5 hospitals filed a usable price — fewer than 10, so no figureNHWashington: 3 hospitals filed a usable price — fewer than 10, so no figureWAIdaho: 3 hospitals filed a usable price — fewer than 10, so no figureIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $1,206 across 22 hospitalsMN$1,206Illinois: median $3,505 across 24 hospitalsIL$3,505Wisconsin: median $3,505 across 37 hospitalsWI$3,505Michigan: median $4,198 across 31 hospitalsMI$4,198New York: median $3,504 across 28 hospitalsNY$3,504Massachusetts: 3 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 2 hospitals filed a usable price — fewer than 10, so no figureORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $2,803 across 13 hospitalsIA$2,803Indiana: median $3,530 across 18 hospitalsIN$3,530Ohio: median $6,120 across 28 hospitalsOH$6,120Pennsylvania: median $3,358 across 43 hospitalsPA$3,358New Jersey: median $3,212 across 34 hospitalsNJ$3,212Connecticut: median $4,197 across 11 hospitalsCT$4,197Rhode Island: 4 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $3,371 across 39 hospitalsCA$3,371Utah: median $2,857 across 22 hospitalsUT$2,857Colorado: 4 hospitals filed a usable price — fewer than 10, so no figureCONebraska: 3 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $4,471 across 15 hospitalsMO$4,471Kentucky: median $7,218 across 10 hospitalsKY$7,218West Virginia: 4 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $3,986 across 19 hospitalsVA$3,986Maryland: median $2,825 across 19 hospitalsMD$2,825Delaware: no hospital in the corpus filed a usable priceDEArizona: 2 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 1 hospital filed a usable price — fewer than 10, so no figureNMKansas: 8 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 3 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $1,428 across 24 hospitalsTN$1,428North Carolina: median $6,355 across 17 hospitalsNC$6,355South Carolina: median $4,745 across 14 hospitalsSC$4,745Oklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: median $893 across 10 hospitalsLA$893Mississippi: median $1,995 across 18 hospitalsMS$1,995Alabama: 3 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $4,563 across 18 hospitalsGA$4,563Hawaii: no hospital in the corpus filed a usable priceHITexas: median $2,586 across 52 hospitalsTX$2,586Florida: median $2,279 across 23 hospitalsFL$2,279
Cash price by state, most expensive first. National median $3,371. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Kentucky KY10$7,218+114%$3,523 – $7,218
North Carolina NC17$6,355+89%$4,379 – $6,355
Ohio OH28$6,120+82%$3,314 – $6,120
South Carolina SC14$4,745+41%$4,745 – $4,745
Georgia GA18$4,563+35%$4,563 – $6,463
Missouri MO15$4,471+33%$2,768 – $4,471
Michigan MI31$4,198+25%$2,242 – $5,447
Connecticut CT11$4,197+24%$4,197 – $9,109
Virginia VA19$3,986+18%$966 – $14,700
Indiana IN18$3,530+5%$2,580 – $4,771
Illinois IL24$3,505+4%$2,894 – $4,471
Wisconsin WI37$3,505+4%$2,912 – $5,953
New York NY28$3,504+4%$2,920 – $7,306
California CA39$3,3710%$3,371 – $4,691
Pennsylvania PA43$3,3580%$2,158 – $26,397
New Jersey NJ34$3,212−5%$2,920 – $3,358
Utah UT22$2,857−15%$2,857 – $3,361
Maryland MD19$2,825−16%$420 – $4,654
Iowa IA13$2,803−17%$2,803 – $2,803
Texas TX52$2,586−23%$1,314 – $3,453
Florida FL23$2,279−32%$2,034 – $3,778
Mississippi MS18$1,995−41%$1,805 – $3,884
Tennessee TN24$1,428−58%$966 – $3,729
Minnesota MN22$1,206−64%$456 – $1,584
Louisiana LA10$893−74%$655 – $1,310
Kansas KS8not enough hospitals filed a usable price
New Hampshire NH5not enough hospitals filed a usable price
Colorado CO4not enough hospitals filed a usable price
Rhode Island RI4not enough hospitals filed a usable price
West Virginia WV4not enough hospitals filed a usable price
Alabama AL3not enough hospitals filed a usable price
Arkansas AR3not enough hospitals filed a usable price
Idaho ID3not enough hospitals filed a usable price
Massachusetts MA3not enough hospitals filed a usable price
North Dakota ND3not enough hospitals filed a usable price
Nebraska NE3not enough hospitals filed a usable price
Washington WA3not enough hospitals filed a usable price
Arizona AZ2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Oregon OR2not enough hospitals filed a usable price
New Mexico NM1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $3,371.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care533$3,371$2,162 – $5,447
Children’s22$3,037$2,158 – $5,099
Critical access85$2,768$1,584 – $5,021
Ownership
For-profit38$3,453$1,895 – $6,362
Government71$2,920$2,056 – $6,355
Non-profit531$3,371$2,158 – $5,119
System affiliation
Part of a system599$3,371$2,075 – $5,447
Independent44$3,358$2,214 – $5,604

Cash price vs list price

Median list price (chargemaster)$6,074
Median cash price$3,371
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

497 hospitals filed a usable inpatient cash price for this code. The median is $3,453 and the average of the middle 60% is $3,587; most fall between $2,054 and $5,447.

Cash price percentiles, inpatient, across 497 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,056$2,242$3,453$4,790$6,944

The most expensive tenth of hospitals charges at least 6.6× what the cheapest tenth charges ($1,056 vs $6,944).

Of the 544 hospitals that filed this code inpatient, 497 gave a usable cash price; 29 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 18 a list price only.

How complete is this

643 of the 3,956 hospitals with a price file in our corpus (16%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 685 hospitals that filed this code at all gave us
Usable cash price — counted643
Cash price carrying a plausibility flag — shown on the compare tool, excluded here22
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded19
Hospitals that filed this code685

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as SO/HL 51/>GSAP RNA ALYS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Cancer gene panel, 51 or more genes, RNA testing (CPT 81456) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81456-cancer-gene-panel-51-or-more-genes-rna-testing