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Procedure price report · Pathology

Blood cancer gene panel, 5 to 50 genes, RNA testing

CPT 81451the billing code this page is about

A laboratory test on blood, bone marrow or lymph tissue that analyzes RNA from 5 to 50 genes, mainly to detect gene fusions and rearrangements; billed once for the panel.

Hospitals typically charge $1,103 cash for this outpatient procedure — the median across 227 hospitals that filed a usable cash price; the average of the middle 60% is $1,102. Most fall between $760 and $1,682 (20th–80th percentile).

Hospitals
227
States
28
Filings dated
Jun 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 23, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 227 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$680$760$1,103$1,653$3,150

The most expensive tenth of hospitals charges at least 4.6× what the cheapest tenth charges ($680 vs $3,150).

How the prices are spread

$493 – $642: 11 hospitals$493$642 – $836: 52 hospitals$836 – $1,088: 33 hospitals$836$1,088 – $1,417: 48 hospitals$1,417 – $1,845: 29 hospitals$1,417$1,845 – $2,403: 11 hospitals$2,403 – $3,128: 5 hospitals$2,403$3,128 – $4,074: 11 hospitals$4,074 – $5,304: 2 hospitals$4,074$5,304 – $6,906: 6 hospitals$5,304median $1,103price bands are equal on a log scale
Hospitals per price band (208 of 227 — the bands cover the 5th to 95th percentile)
FromToHospitals
$493$64211
$642$83652
$836$1,08833
$1,088$1,41748
$1,417$1,84529
$1,845$2,40311
$2,403$3,1285
$3,128$4,07411
$4,074$5,3042
$5,304$6,9066

By state

The median cash price in each state, against the national median of $1,103.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: 2 hospitals filed a usable price — fewer than 10, so no figureWAIdaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: 1 hospital filed a usable price — fewer than 10, so no figureMNIllinois: 4 hospitals filed a usable price — fewer than 10, so no figureILWisconsin: 2 hospitals filed a usable price — fewer than 10, so no figureWIMichigan: 4 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $760 across 18 hospitalsNY$760Massachusetts: 3 hospitals filed a usable price — fewer than 10, so no figureMAOregon: no hospital in the corpus filed a usable priceORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $729 across 11 hospitalsIA$729Indiana: no hospital in the corpus filed a usable priceINOhio: 1 hospital filed a usable price — fewer than 10, so no figureOHPennsylvania: median $6,868 across 21 hospitalsPA$6,868New Jersey: median $835 across 23 hospitalsNJ$835Connecticut: 4 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 4 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $879 across 34 hospitalsCA$879Utah: no hospital in the corpus filed a usable priceUTColorado: no hospital in the corpus filed a usable priceCONebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $1,442 across 10 hospitalsMO$1,442Kentucky: no hospital in the corpus filed a usable priceKYWest Virginia: no hospital in the corpus filed a usable priceWVVirginia: 5 hospitals filed a usable price — fewer than 10, so no figureVAMaryland: no hospital in the corpus filed a usable priceMDDelaware: no hospital in the corpus filed a usable priceDEArizona: 1 hospital filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: no hospital in the corpus filed a usable priceKSArkansas: 2 hospitals filed a usable price — fewer than 10, so no figureARTennessee: 5 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: median $1,653 across 10 hospitalsNC$1,653South Carolina: no hospital in the corpus filed a usable priceSCOklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: no hospital in the corpus filed a usable priceLAMississippi: median $592 across 10 hospitalsMS$592Alabama: 1 hospital filed a usable price — fewer than 10, so no figureALGeorgia: 5 hospitals filed a usable price — fewer than 10, so no figureGAHawaii: no hospital in the corpus filed a usable priceHITexas: median $1,103 across 30 hospitalsTX$1,103Florida: median $680 across 11 hospitalsFL$680
Cash price by state, most expensive first. National median $1,103. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Pennsylvania PA21$6,868+523%$237 – $9,886
North Carolina NC10$1,653+50%$1,653 – $1,653
Missouri MO10$1,442+31%$1,418 – $1,442
Texas TX30$1,1030%$1,103 – $1,103
California CA34$879−20%$879 – $1,322
New Jersey NJ23$835−24%$760 – $835
New York NY18$760−31%$760 – $3,109
Iowa IA11$729−34%$729 – $729
Florida FL11$680−38%$680 – $2,791
Mississippi MS10$592−46%$518 – $1,085
Georgia GA5not enough hospitals filed a usable price
Tennessee TN5not enough hospitals filed a usable price
Virginia VA5not enough hospitals filed a usable price
Connecticut CT4not enough hospitals filed a usable price
Illinois IL4not enough hospitals filed a usable price
Michigan MI4not enough hospitals filed a usable price
Rhode Island RI4not enough hospitals filed a usable price
Massachusetts MA3not enough hospitals filed a usable price
Arkansas AR2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Washington WA2not enough hospitals filed a usable price
Wisconsin WI2not enough hospitals filed a usable price
Alabama AL1not enough hospitals filed a usable price
Arizona AZ1not enough hospitals filed a usable price
Minnesota MN1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price
Ohio OH1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $1,103.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care215$1,103$760 – $1,704
Children’s2fewer than 20 hospitals
Critical access10fewer than 20 hospitals
Ownership
For-profit19fewer than 20 hospitals
Government27$1,653$760 – $1,867
Non-profit181$1,048$760 – $1,627
System affiliation
Part of a system217$1,103$760 – $1,655
Independent10fewer than 20 hospitals

Cash price vs list price

Median list price (chargemaster)$2,279
Median cash price$1,103
Cash as a share of list, median hospital56%

At the typical hospital, asking for the cash price cuts the list price by about 44%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

167 hospitals filed a usable inpatient cash price for this code. The median is $1,103 and the average of the middle 60% is $1,247; most fall between $840 and $2,222.

Cash price percentiles, inpatient, across 167 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$567$879$1,103$1,669$3,798

The most expensive tenth of hospitals charges at least 6.7× what the cheapest tenth charges ($567 vs $3,798).

Of the 181 hospitals that filed this code inpatient, 167 gave a usable cash price; 7 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 7 a list price only.

How complete is this

227 of the 3,956 hospitals with a price file in our corpus (6%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 237 hospitals that filed this code at all gave us
Usable cash price — counted227
Cash price carrying a plausibility flag — shown on the compare tool, excluded here2
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded7
Hospitals that filed this code237

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 23, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as HL NEO GSAP 5-50 RNA ALYS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Blood cancer gene panel, 5 to 50 genes, RNA testing (CPT 81451) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81451-blood-cancer-gene-panel-5-to-50-genes-rna-testing