HRHospitalRates.comCompare prices

Procedure price report · Pathology

Whole genome DNA sequencing for the patient

CPT 81425the billing code this page is about

Sequencing of the patient's full DNA, not just the coding regions, to look for disease-causing variants; this code covers the tested individual only.

Hospitals typically charge $4,439 cash for this outpatient procedure — the median across 444 hospitals that filed a usable cash price; the average of the middle 60% is $4,170. Most fall between $2,175 and $7,240 (20th–80th percentile).

Hospitals
444
States
38
Filings dated
Sep 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 444 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,979$2,280$4,439$6,457$11,497

The most expensive tenth of hospitals charges at least 5.8× what the cheapest tenth charges ($1,979 vs $11,497).

How the prices are spread

$1,553 – $1,901: 19 hospitals$1,553$1,901 – $2,326: 73 hospitals$2,326 – $2,847: 39 hospitals$2,326$2,847 – $3,484: 21 hospitals$3,484 – $4,263: 34 hospitals$3,484$4,263 – $5,217: 78 hospitals$5,217 – $6,384: 33 hospitals$5,217$6,384 – $7,813: 48 hospitals$7,813 – $9,561: 12 hospitals$7,813$9,561 – $11,700: 47 hospitals$9,561median $4,439price bands are equal on a log scale
Hospitals per price band (404 of 444 — the bands cover the 5th to 95th percentile)
FromToHospitals
$1,553$1,90119
$1,901$2,32673
$2,326$2,84739
$2,847$3,48421
$3,484$4,26334
$4,263$5,21778
$5,217$6,38433
$6,384$7,81348
$7,813$9,56112
$9,561$11,70047

By state

The median cash price in each state, against the national median of $4,439.

Alaska: 1 hospital filed a usable price — fewer than 10, so no figureAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: median $2,790 across 10 hospitalsWA$2,790Idaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $3,520 across 18 hospitalsMN$3,520Illinois: median $6,567 across 12 hospitalsIL$6,567Wisconsin: median $3,600 across 13 hospitalsWI$3,600Michigan: median $2,359 across 16 hospitalsMI$2,359New York: median $5,031 across 19 hospitalsNY$5,031Massachusetts: 2 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 2 hospitals filed a usable price — fewer than 10, so no figureORNevada: 2 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $4,830 across 11 hospitalsIA$4,830Indiana: median $7,240 across 13 hospitalsIN$7,240Ohio: median $1,979 across 26 hospitalsOH$1,979Pennsylvania: median $4,439 across 19 hospitalsPA$4,439New Jersey: median $5,534 across 24 hospitalsNJ$5,534Connecticut: 1 hospital filed a usable price — fewer than 10, so no figureCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $11,497 across 27 hospitalsCA$11,497Utah: 1 hospital filed a usable price — fewer than 10, so no figureUTColorado: 2 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 4 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 8 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: 4 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $3,083 across 16 hospitalsVA$3,083Maryland: median $2,075 across 13 hospitalsMD$2,075Delaware: no hospital in the corpus filed a usable priceDEArizona: 5 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 1 hospital filed a usable price — fewer than 10, so no figureNMKansas: 2 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 3 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $6,457 across 11 hospitalsTN$6,457North Carolina: median $2,280 across 30 hospitalsNC$2,280South Carolina: median $11,700 across 15 hospitalsSC$11,700Oklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: median $2,906 across 16 hospitalsLA$2,906Mississippi: 2 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: no hospital in the corpus filed a usable priceALGeorgia: median $2,492 across 18 hospitalsGA$2,492Hawaii: no hospital in the corpus filed a usable priceHITexas: median $2,175 across 59 hospitalsTX$2,175Florida: median $5,031 across 14 hospitalsFL$5,031
Cash price by state, most expensive first. National median $4,439. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
South Carolina SC15$11,700+164%$9,056 – $11,700
California CA27$11,497+159%$9,500 – $11,497
Indiana IN13$7,240+63%$6,279 – $9,786
Illinois IL12$6,567+48%$4,830 – $6,567
Tennessee TN11$6,457+45%$5,233 – $6,457
New Jersey NJ24$5,534+25%$5,031 – $5,534
Florida FL14$5,031+13%$2,200 – $12,720
New York NY19$5,031+13%$4,439 – $5,031
Iowa IA11$4,830+9%$4,830 – $4,830
Pennsylvania PA19$4,4390%$4,397 – $4,439
Wisconsin WI13$3,600−19%$3,600 – $5,811
Minnesota MN18$3,520−21%$3,520 – $4,069
Virginia VA16$3,083−31%$2,936 – $7,547
Louisiana LA16$2,906−35%$2,044 – $4,522
Washington WA10$2,790−37%$2,790 – $5,581
Georgia GA18$2,492−44%$2,415 – $6,405
Michigan MI16$2,359−47%$1,377 – $6,943
North Carolina NC30$2,280−49%$2,280 – $4,877
Texas TX59$2,175−51%$2,175 – $2,517
Maryland MD13$2,075−53%$1,737 – $2,825
Ohio OH26$1,979−55%$1,979 – $6,182
Kentucky KY8not enough hospitals filed a usable price
Arizona AZ5not enough hospitals filed a usable price
Missouri MO4not enough hospitals filed a usable price
West Virginia WV4not enough hospitals filed a usable price
Arkansas AR3not enough hospitals filed a usable price
Colorado CO2not enough hospitals filed a usable price
Kansas KS2not enough hospitals filed a usable price
Massachusetts MA2not enough hospitals filed a usable price
Mississippi MS2not enough hospitals filed a usable price
North Dakota ND2not enough hospitals filed a usable price
Nevada NV2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Oregon OR2not enough hospitals filed a usable price
Alaska AK1not enough hospitals filed a usable price
Connecticut CT1not enough hospitals filed a usable price
New Mexico NM1not enough hospitals filed a usable price
Utah UT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $4,439.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care370$4,439$2,175 – $7,240
Children’s25$4,000$1,623 – $5,581
Critical access48$3,600$2,280 – $7,952
Ownership
For-profit40$2,415$1,979 – $9,500
Government49$4,241$2,280 – $5,786
Non-profit354$4,439$2,200 – $7,260
System affiliation
Part of a system418$4,439$2,175 – $7,240
Independent26$5,031$2,575 – $6,182

Cash price vs list price

Median list price (chargemaster)$6,037
Median cash price$4,439
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

299 hospitals filed a usable inpatient cash price for this code. The median is $3,704 and the average of the middle 60% is $3,933; most fall between $2,175 and $7,260.

Cash price percentiles, inpatient, across 299 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,848$2,175$3,704$6,405$11,497

The most expensive tenth of hospitals charges at least 6.2× what the cheapest tenth charges ($1,848 vs $11,497).

Of the 339 hospitals that filed this code inpatient, 299 gave a usable cash price; 32 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 8 a list price only.

How complete is this

444 of the 3,956 hospitals with a price file in our corpus (11%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 493 hospitals that filed this code at all gave us
Usable cash price — counted444
Cash price carrying a plausibility flag — shown on the compare tool, excluded here38
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded8
Hospitals that filed this code493

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as GENOME SEQUENCE ANALYSIS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Whole genome DNA sequencing for the patient (CPT 81425) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81425-whole-genome-dna-sequencing-for-the-patient