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Procedure price report · Pathology

Whole exome DNA sequencing, each family member compared

CPT 81416the billing code this page is about

Exome sequencing of one relative, such as a parent, used for comparison with the patient's result; billed once for each additional person tested.

Hospitals typically charge $6,600 cash for this outpatient procedure — the median across 460 hospitals that filed a usable cash price; the average of the middle 60% is $7,234. Most fall between $1,116 and $15,400 (20th–80th percentile).

Hospitals
460
States
44
Filings dated
Sep 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 460 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$587$1,653$6,600$13,200$27,423

The most expensive tenth of hospitals charges at least 47× what the cheapest tenth charges ($587 vs $27,423).

How the prices are spread

$525 – $781: 41 hospitals$525$781 – $1,161: 38 hospitals$1,161 – $1,726: 25 hospitals$1,161$1,726 – $2,566: 29 hospitals$2,566 – $3,815: 25 hospitals$2,566$3,815 – $5,672: 36 hospitals$5,672 – $8,433: 40 hospitals$5,672$8,433 – $12,539: 82 hospitals$12,539 – $18,644: 65 hospitals$12,539$18,644 – $27,720: 38 hospitals$18,644median $6,600price bands are equal on a log scale
Hospitals per price band (419 of 460 — the bands cover the 5th to 95th percentile)
FromToHospitals
$525$78141
$781$1,16138
$1,161$1,72625
$1,726$2,56629
$2,566$3,81525
$3,815$5,67236
$5,672$8,43340
$8,433$12,53982
$12,539$18,64465
$18,644$27,72038

By state

The median cash price in each state, against the national median of $6,600.

Alaska: 2 hospitals filed a usable price — fewer than 10, so no figureAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: 3 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $4,939 across 10 hospitalsWA$4,939Idaho: 1 hospital filed a usable price — fewer than 10, so no figureIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $831 across 18 hospitalsMN$831Illinois: median $27,720 across 19 hospitalsIL$27,720Wisconsin: median $1,797 across 15 hospitalsWI$1,797Michigan: 6 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $12,000 across 22 hospitalsNY$12,000Massachusetts: 2 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 8 hospitals filed a usable price — fewer than 10, so no figureORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: 1 hospital filed a usable price — fewer than 10, so no figureWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $11,520 across 13 hospitalsIA$11,520Indiana: median $1,788 across 13 hospitalsIN$1,788Ohio: median $7,002 across 24 hospitalsOH$7,002Pennsylvania: median $3,501 across 18 hospitalsPA$3,501New Jersey: median $13,200 across 31 hospitalsNJ$13,200Connecticut: 4 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $27,423 across 23 hospitalsCA$27,423Utah: 3 hospitals filed a usable price — fewer than 10, so no figureUTColorado: 8 hospitals filed a usable price — fewer than 10, so no figureCONebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: 8 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: median $10,325 across 10 hospitalsKY$10,325West Virginia: 4 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $4,900 across 11 hospitalsVA$4,900Maryland: median $2,328 across 18 hospitalsMD$2,328Delaware: no hospital in the corpus filed a usable priceDEArizona: 3 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 1 hospital filed a usable price — fewer than 10, so no figureNMKansas: 4 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 3 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $10,238 across 12 hospitalsTN$10,238North Carolina: median $11,400 across 16 hospitalsNC$11,400South Carolina: median $11,451 across 12 hospitalsSC$11,451Oklahoma: median $1,653 across 16 hospitalsOK$1,653Louisiana: median $1,140 across 13 hospitalsLA$1,140Mississippi: 3 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 1 hospital filed a usable price — fewer than 10, so no figureALGeorgia: median $6,040 across 14 hospitalsGA$6,040Hawaii: no hospital in the corpus filed a usable priceHITexas: median $2,755 across 40 hospitalsTX$2,755Florida: median $963 across 20 hospitalsFL$963
Cash price by state, most expensive first. National median $6,600. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Illinois IL19$27,720+320%$5,286 – $27,720
California CA23$27,423+316%$27,423 – $27,423
New Jersey NJ31$13,200+100%$12,000 – $18,306
New York NY22$12,000+82%$8,918 – $12,000
Iowa IA13$11,520+75%$11,520 – $11,520
South Carolina SC12$11,451+74%$11,451 – $11,451
North Carolina NC16$11,400+73%$525 – $11,907
Kentucky KY10$10,325+56%$10,325 – $10,325
Tennessee TN12$10,238+55%$5,498 – $15,400
Ohio OH24$7,002+6%$7,002 – $17,382
Georgia GA14$6,040−8%$1,051 – $6,040
Washington WA10$4,939−25%$1,339 – $4,939
Virginia VA11$4,900−26%$4,900 – $41,675
Pennsylvania PA18$3,501−47%$2,853 – $20,288
Texas TX40$2,755−58%$587 – $6,600
Maryland MD18$2,328−65%$536 – $3,412
Wisconsin WI15$1,797−73%$1,116 – $10,440
Indiana IN13$1,788−73%$1,565 – $2,529
Oklahoma OK16$1,653−75%$1,653 – $1,961
Louisiana LA13$1,140−83%$550 – $10,784
Florida FL20$963−85%$499 – $1,260
Minnesota MN18$831−87%$560 – $1,091
Colorado CO8not enough hospitals filed a usable price
Missouri MO8not enough hospitals filed a usable price
Oregon OR8not enough hospitals filed a usable price
Michigan MI6not enough hospitals filed a usable price
Connecticut CT4not enough hospitals filed a usable price
Kansas KS4not enough hospitals filed a usable price
West Virginia WV4not enough hospitals filed a usable price
Arkansas AR3not enough hospitals filed a usable price
Arizona AZ3not enough hospitals filed a usable price
Mississippi MS3not enough hospitals filed a usable price
North Dakota ND3not enough hospitals filed a usable price
New Hampshire NH3not enough hospitals filed a usable price
Utah UT3not enough hospitals filed a usable price
Alaska AK2not enough hospitals filed a usable price
Massachusetts MA2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
Alabama AL1not enough hospitals filed a usable price
Idaho ID1not enough hospitals filed a usable price
New Mexico NM1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price
Wyoming WY1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $6,600.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care390$7,002$1,322 – $15,600
Children’s23$3,207$759 – $5,553
Critical access46$4,900$1,091 – $14,850
Ownership
For-profit36$6,040$1,620 – $36,000
Government48$4,800$963 – $12,000
Non-profit375$6,760$1,116 – $15,455
System affiliation
Part of a system422$6,600$1,116 – $15,400
Independent38$3,390$907 – $14,746

Cash price vs list price

Median list price (chargemaster)$12,348
Median cash price$6,600
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

312 hospitals filed a usable inpatient cash price for this code. The median is $5,553 and the average of the middle 60% is $6,458; most fall between $1,051 and $15,400.

Cash price percentiles, inpatient, across 312 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$587$1,116$5,553$11,614$27,423

The most expensive tenth of hospitals charges at least 47× what the cheapest tenth charges ($587 vs $27,423).

Of the 348 hospitals that filed this code inpatient, 312 gave a usable cash price; 29 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 7 a list price only.

How complete is this

460 of the 3,956 hospitals with a price file in our corpus (12%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 509 hospitals that filed this code at all gave us
Usable cash price — counted460
Cash price carrying a plausibility flag — shown on the compare tool, excluded here34
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded13
Hospitals that filed this code509

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as EXOME SEQUENCE ANALYSIS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Whole exome DNA sequencing, each family member compared (CPT 81416) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81416-whole-exome-dna-sequencing-each-family-member-compared