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Procedure price report · Pathology

Whole exome DNA sequencing for the patient

CPT 81415the billing code this page is about

Sequencing of the protein-coding portions of the patient's genes to look for disease-causing variants; this code covers the tested individual only, not relatives.

Hospitals typically charge $4,229 cash for this outpatient procedure — the median across 640 hospitals that filed a usable cash price; the average of the middle 60% is $4,439. Most fall between $2,010 and $7,768 (20th–80th percentile).

Hospitals
640
States
45
Filings dated
Dec 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 640 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$986$2,442$4,229$7,002$10,926

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($986 vs $10,926).

How the prices are spread

$587 – $808: 25 hospitals$587$808 – $1,112: 20 hospitals$1,112 – $1,530: 27 hospitals$1,112$1,530 – $2,105: 42 hospitals$2,105 – $2,896: 76 hospitals$2,105$2,896 – $3,985: 79 hospitals$3,985 – $5,483: 122 hospitals$3,985$5,483 – $7,545: 86 hospitals$7,545 – $10,382: 50 hospitals$7,545$10,382 – $14,286: 58 hospitals$10,382median $4,229price bands are equal on a log scale
Hospitals per price band (585 of 640 — the bands cover the 5th to 95th percentile)
FromToHospitals
$587$80825
$808$1,11220
$1,112$1,53027
$1,530$2,10542
$2,105$2,89676
$2,896$3,98579
$3,985$5,483122
$5,483$7,54586
$7,545$10,38250
$10,382$14,28658

By state

The median cash price in each state, against the national median of $4,229.

Alaska: 1 hospital filed a usable price — fewer than 10, so no figureAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: 4 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $1,967 across 12 hospitalsWA$1,967Idaho: 1 hospital filed a usable price — fewer than 10, so no figureIDMontana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $2,124 across 22 hospitalsMN$2,124Illinois: median $11,042 across 22 hospitalsIL$11,042Wisconsin: median $2,700 across 15 hospitalsWI$2,700Michigan: median $5,670 across 12 hospitalsMI$5,670New York: median $5,736 across 34 hospitalsNY$5,736Massachusetts: 3 hospitals filed a usable price — fewer than 10, so no figureMAOregon: median $5,736 across 11 hospitalsOR$5,736Nevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: 1 hospital filed a usable price — fewer than 10, so no figureWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $4,589 across 13 hospitalsIA$4,589Indiana: median $2,385 across 14 hospitalsIN$2,385Ohio: median $7,768 across 51 hospitalsOH$7,768Pennsylvania: median $5,497 across 28 hospitalsPA$5,497New Jersey: median $5,258 across 33 hospitalsNJ$5,258Connecticut: 1 hospital filed a usable price — fewer than 10, so no figureCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $10,926 across 25 hospitalsCA$10,926Utah: 3 hospitals filed a usable price — fewer than 10, so no figureUTColorado: median $3,075 across 10 hospitalsCO$3,075Nebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $7,657 across 14 hospitalsMO$7,657Kentucky: 9 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: 6 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $3,374 across 24 hospitalsVA$3,374Maryland: median $2,529 across 19 hospitalsMD$2,529Delaware: no hospital in the corpus filed a usable priceDEArizona: 5 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 3 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 7 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 3 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $6,020 across 11 hospitalsTN$6,020North Carolina: median $4,326 across 27 hospitalsNC$4,326South Carolina: median $6,829 across 13 hospitalsSC$6,829Oklahoma: median $1,653 across 16 hospitalsOK$1,653Louisiana: median $1,536 across 16 hospitalsLA$1,536Mississippi: 2 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 3 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $1,515 across 40 hospitalsGA$1,515Hawaii: no hospital in the corpus filed a usable priceHITexas: median $3,339 across 75 hospitalsTX$3,339Florida: median $963 across 23 hospitalsFL$963
Cash price by state, most expensive first. National median $4,229. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Illinois IL22$11,042+161%$4,200 – $11,042
California CA25$10,926+158%$5,590 – $10,926
Ohio OH51$7,768+84%$7,002 – $8,626
Missouri MO14$7,657+81%$2,793 – $9,464
South Carolina SC13$6,829+61%$6,829 – $6,829
Tennessee TN11$6,020+42%$2,190 – $6,134
New York NY34$5,736+36%$4,780 – $10,597
Oregon OR11$5,736+36%$4,398 – $5,736
Michigan MI12$5,670+34%$5,670 – $6,596
Pennsylvania PA28$5,497+30%$2,676 – $12,586
New Jersey NJ33$5,258+24%$4,780 – $13,648
Iowa IA13$4,589+9%$4,589 – $4,589
North Carolina NC27$4,326+2%$2,952 – $4,562
Virginia VA24$3,374−20%$2,758 – $6,134
Texas TX75$3,339−21%$1,350 – $3,589
Colorado CO10$3,075−27%$1,840 – $4,914
Wisconsin WI15$2,700−36%$2,700 – $5,521
Maryland MD19$2,529−40%$1,253 – $3,919
Indiana IN14$2,385−44%$2,087 – $3,737
Minnesota MN22$2,124−50%$340 – $2,640
Washington WA12$1,967−53%$1,967 – $7,240
Oklahoma OK16$1,653−61%$1,653 – $4,160
Louisiana LA16$1,536−64%$990 – $3,944
Georgia GA40$1,515−64%$1,515 – $3,667
Florida FL23$963−77%$397 – $6,296
Kentucky KY9not enough hospitals filed a usable price
Kansas KS7not enough hospitals filed a usable price
West Virginia WV6not enough hospitals filed a usable price
Arizona AZ5not enough hospitals filed a usable price
New Hampshire NH4not enough hospitals filed a usable price
Alabama AL3not enough hospitals filed a usable price
Arkansas AR3not enough hospitals filed a usable price
Massachusetts MA3not enough hospitals filed a usable price
North Dakota ND3not enough hospitals filed a usable price
New Mexico NM3not enough hospitals filed a usable price
Utah UT3not enough hospitals filed a usable price
Mississippi MS2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
Alaska AK1not enough hospitals filed a usable price
Connecticut CT1not enough hospitals filed a usable price
Idaho ID1not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price
Wyoming WY1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $4,229.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care541$4,326$1,967 – $7,965
Children’s29$2,793$1,335 – $5,670
Critical access67$3,737$2,640 – $6,156
Ownership
For-profit61$4,331$2,190 – $13,234
Government77$3,908$1,536 – $4,780
Non-profit499$4,307$2,100 – $7,768
System affiliation
Part of a system593$4,307$2,100 – $7,768
Independent47$4,050$1,525 – $7,048

Cash price vs list price

Median list price (chargemaster)$7,560
Median cash price$4,229
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

471 hospitals filed a usable inpatient cash price for this code. The median is $4,160 and the average of the middle 60% is $4,339; most fall between $1,967 and $7,768.

Cash price percentiles, inpatient, across 471 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$1,010$2,250$4,160$7,002$10,926

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($1,010 vs $10,926).

Of the 514 hospitals that filed this code inpatient, 471 gave a usable cash price; 35 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 8 a list price only.

How complete is this

640 of the 3,956 hospitals with a price file in our corpus (16%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 681 hospitals that filed this code at all gave us
Usable cash price — counted640
Cash price carrying a plausibility flag — shown on the compare tool, excluded here31
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded8
Hospitals that filed this code681

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as EXOME SEQUENCE ANALYSIS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Whole exome DNA sequencing for the patient (CPT 81415) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81415-whole-exome-dna-sequencing-for-the-patient