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Procedure price report · Pathology

TP53 gene test, full gene sequencing

CPT 81351the billing code this page is about

Laboratory test that reads the entire coding sequence of the TP53 gene to look for mutations.

Hospitals typically charge $824 cash for this outpatient procedure — the median across 771 hospitals that filed a usable cash price; the average of the middle 60% is $851. Most fall between $315 and $1,512 (20th–80th percentile).

Hospitals
771
States
47
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 771 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$215$430$824$1,386$2,250

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($215 vs $2,250).

How the prices are spread

$126 – $172: 25 hospitals$126$172 – $236: 24 hospitals$236 – $322: 70 hospitals$236$322 – $440: 41 hospitals$440 – $602: 72 hospitals$440$602 – $824: 114 hospitals$824 – $1,126: 148 hospitals$824$1,126 – $1,540: 94 hospitals$1,540 – $2,105: 62 hospitals$1,540$2,105 – $2,879: 55 hospitals$2,105median $824price bands are equal on a log scale
Hospitals per price band (705 of 771 — the bands cover the 5th to 95th percentile)
FromToHospitals
$126$17225
$172$23624
$236$32270
$322$44041
$440$60272
$602$824114
$824$1,126148
$1,126$1,54094
$1,540$2,10562
$2,105$2,87955

By state

The median cash price in each state, against the national median of $824.

Alaska: no hospital in the corpus filed a usable priceAKMaine: median $687 across 15 hospitalsME$687Vermont: 2 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 2 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $446 across 27 hospitalsWA$446Idaho: 4 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 1 hospital filed a usable price — fewer than 10, so no figureNDMinnesota: median $266 across 27 hospitalsMN$266Illinois: median $1,348 across 34 hospitalsIL$1,348Wisconsin: median $1,084 across 31 hospitalsWI$1,084Michigan: median $886 across 13 hospitalsMI$886New York: median $642 across 31 hospitalsNY$642Massachusetts: median $1,690 across 13 hospitalsMA$1,690Oregon: 6 hospitals filed a usable price — fewer than 10, so no figureORNevada: 4 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $616 across 17 hospitalsIA$616Indiana: median $484 across 18 hospitalsIN$484Ohio: median $1,297 across 58 hospitalsOH$1,297Pennsylvania: median $1,122 across 31 hospitalsPA$1,122New Jersey: median $706 across 34 hospitalsNJ$706Connecticut: 6 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $1,081 across 24 hospitalsCA$1,081Utah: median $2,632 across 23 hospitalsUT$2,632Colorado: 5 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 8 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: median $900 across 15 hospitalsKY$900West Virginia: median $126 across 19 hospitalsWV$126Virginia: median $824 across 26 hospitalsVA$824Maryland: median $1,881 across 11 hospitalsMD$1,881Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 4 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 7 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 7 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 4 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $808 across 25 hospitalsTN$808North Carolina: median $1,384 across 25 hospitalsNC$1,384South Carolina: median $1,392 across 21 hospitalsSC$1,392Oklahoma: median $1,341 across 12 hospitalsOK$1,341Louisiana: median $477 across 15 hospitalsLA$477Mississippi: median $498 across 20 hospitalsMS$498Alabama: 3 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $807 across 40 hospitalsGA$807Hawaii: 1 hospital filed a usable price — fewer than 10, so no figureHITexas: median $417 across 59 hospitalsTX$417Florida: median $184 across 15 hospitalsFL$184
Cash price by state, most expensive first. National median $824. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT23$2,632+219%$2,632 – $3,096
Maryland MD11$1,881+128%$292 – $2,559
Massachusetts MA13$1,690+105%$750 – $1,867
South Carolina SC21$1,392+69%$1,156 – $1,521
North Carolina NC25$1,384+68%$397 – $1,397
Illinois IL34$1,348+64%$616 – $1,930
Oklahoma OK12$1,341+63%$536 – $2,117
Ohio OH58$1,297+57%$1,008 – $2,879
Pennsylvania PA31$1,122+36%$87 – $6,356
Wisconsin WI31$1,084+32%$84 – $1,584
California CA24$1,081+31%$666 – $1,081
Kentucky KY15$900+9%$437 – $900
Michigan MI13$886+8%$585 – $894
Virginia VA26$8240%$265 – $1,081
Tennessee TN25$808−2%$482 – $824
Georgia GA40$807−2%$293 – $1,204
New Jersey NJ34$706−14%$642 – $1,844
Maine ME15$687−17%$366 – $1,555
New York NY31$642−22%$642 – $1,473
Iowa IA17$616−25%$616 – $667
Mississippi MS20$498−40%$242 – $888
Indiana IN18$484−41%$373 – $900
Louisiana LA15$477−42%$315 – $1,046
Washington WA27$446−46%$249 – $1,198
Texas TX59$417−49%$276 – $616
Minnesota MN27$266−68%$82 – $269
Florida FL15$184−78%$184 – $642
West Virginia WV19$126−85%$126 – $1,588
Missouri MO8not enough hospitals filed a usable price
Kansas KS7not enough hospitals filed a usable price
New Mexico NM7not enough hospitals filed a usable price
Connecticut CT6not enough hospitals filed a usable price
Oregon OR6not enough hospitals filed a usable price
Colorado CO5not enough hospitals filed a usable price
Arkansas AR4not enough hospitals filed a usable price
Arizona AZ4not enough hospitals filed a usable price
Idaho ID4not enough hospitals filed a usable price
Nevada NV4not enough hospitals filed a usable price
Alabama AL3not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
South Dakota SD3not enough hospitals filed a usable price
New Hampshire NH2not enough hospitals filed a usable price
Vermont VT2not enough hospitals filed a usable price
Hawaii HI1not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
North Dakota ND1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $824.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care644$824$361 – $1,521
Children’s15fewer than 20 hospitals
Critical access108$677$265 – $1,412
Ownership
For-profit43$815$276 – $1,488
Government108$642$293 – $1,297
Non-profit616$838$366 – $1,588
System affiliation
Part of a system703$824$309 – $1,512
Independent68$738$375 – $1,473

Cash price vs list price

Median list price (chargemaster)$1,680
Median cash price$824
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

581 hospitals filed a usable inpatient cash price for this code. The median is $824 and the average of the middle 60% is $873; most fall between $375 and $1,584.

Cash price percentiles, inpatient, across 581 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$266$444$824$1,397$2,567

The most expensive tenth of hospitals charges at least 9.6× what the cheapest tenth charges ($266 vs $2,567).

Of the 652 hospitals that filed this code inpatient, 581 gave a usable cash price; 45 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 26 a list price only.

How complete is this

771 of the 3,956 hospitals with a price file in our corpus (19%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 856 hospitals that filed this code at all gave us
Usable cash price — counted771
Cash price carrying a plausibility flag — shown on the compare tool, excluded here61
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded23
Hospitals that filed this code856

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as TP53 GENE FULL GENE SEQUENCE.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “TP53 gene test, full gene sequencing (CPT 81351) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81351-tp53-gene-test-full-gene-sequencing