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Procedure price report · Pathology

Thymidylate synthase gene test for common variants

CPT 81346the billing code this page is about

Laboratory test of the TYMS gene for common repeat variants that affect how the body handles certain chemotherapy drugs.

Hospitals typically charge $266 cash for this outpatient procedure — the median across 177 hospitals that filed a usable cash price; the average of the middle 60% is $394. Most fall between $175 and $1,193 (20th–80th percentile).

Hospitals
177
States
27
Filings dated
Nov 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 177 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$140$175$266$524$1,210

The most expensive tenth of hospitals charges at least 8.6× what the cheapest tenth charges ($140 vs $1,210).

How the prices are spread

$121 – $152: 14 hospitals$121$152 – $191: 32 hospitals$191 – $241: 20 hospitals$191$241 – $303: 26 hospitals$303 – $382: 22 hospitals$303$382 – $481: 9 hospitals$481 – $606: 4 hospitals$481$606 – $763: 1 hospitals$763 – $960: 2 hospitals$763$960 – $1,210: 36 hospitals$960median $266price bands are equal on a log scale
Hospitals per price band (166 of 177 — the bands cover the 5th to 95th percentile)
FromToHospitals
$121$15214
$152$19132
$191$24120
$241$30326
$303$38222
$382$4819
$481$6064
$606$7631
$763$9602
$960$1,21036

By state

The median cash price in each state, against the national median of $266.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: 1 hospital filed a usable price — fewer than 10, so no figureWAIdaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: no hospital in the corpus filed a usable priceMNIllinois: median $175 across 12 hospitalsIL$175Wisconsin: median $140 across 14 hospitalsWI$140Michigan: 4 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $175 across 13 hospitalsNY$175Massachusetts: 3 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 5 hospitals filed a usable price — fewer than 10, so no figureORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $350 across 11 hospitalsIA$350Indiana: median $253 across 13 hospitalsIN$253Ohio: 2 hospitals filed a usable price — fewer than 10, so no figureOHPennsylvania: median $46 across 13 hospitalsPA$46New Jersey: median $192 across 22 hospitalsNJ$192Connecticut: no hospital in the corpus filed a usable priceCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $1,210 across 19 hospitalsCA$1,210Utah: no hospital in the corpus filed a usable priceUTColorado: no hospital in the corpus filed a usable priceCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 2 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 2 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: 2 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: 4 hospitals filed a usable price — fewer than 10, so no figureVAMaryland: no hospital in the corpus filed a usable priceMDDelaware: no hospital in the corpus filed a usable priceDEArizona: 1 hospital filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: no hospital in the corpus filed a usable priceKSArkansas: 1 hospital filed a usable price — fewer than 10, so no figureARTennessee: 1 hospital filed a usable price — fewer than 10, so no figureTNNorth Carolina: no hospital in the corpus filed a usable priceNCSouth Carolina: no hospital in the corpus filed a usable priceSCOklahoma: 6 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 2 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: no hospital in the corpus filed a usable priceMSAlabama: no hospital in the corpus filed a usable priceALGeorgia: 6 hospitals filed a usable price — fewer than 10, so no figureGAHawaii: 2 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $1,193 across 14 hospitalsTX$1,193Florida: 1 hospital filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $266. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA19$1,210+355%$1,210 – $1,210
Texas TX14$1,193+349%$1,193 – $1,193
Iowa IA11$350+32%$350 – $350
Indiana IN13$253−5%$222 – $358
New Jersey NJ22$192−28%$175 – $192
Illinois IL12$175−34%$175 – $251
New York NY13$175−34%$175 – $175
Wisconsin WI14$140−47%$140 – $140
Pennsylvania PA13$46−83%$37 – $1,000
Georgia GA6not enough hospitals filed a usable price
Oklahoma OK6not enough hospitals filed a usable price
Oregon OR5not enough hospitals filed a usable price
Michigan MI4not enough hospitals filed a usable price
Virginia VA4not enough hospitals filed a usable price
Massachusetts MA3not enough hospitals filed a usable price
Hawaii HI2not enough hospitals filed a usable price
Kentucky KY2not enough hospitals filed a usable price
Louisiana LA2not enough hospitals filed a usable price
Missouri MO2not enough hospitals filed a usable price
Ohio OH2not enough hospitals filed a usable price
West Virginia WV2not enough hospitals filed a usable price
Arkansas AR1not enough hospitals filed a usable price
Arizona AZ1not enough hospitals filed a usable price
Florida FL1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price
Tennessee TN1not enough hospitals filed a usable price
Washington WA1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $266.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care158$251$175 – $1,193
Children’s1fewer than 20 hospitals
Critical access18fewer than 20 hospitals
Ownership
For-profit10fewer than 20 hospitals
Government15fewer than 20 hospitals
Non-profit152$265$175 – $1,193
System affiliation
Part of a system167$266$175 – $1,193
Independent10fewer than 20 hospitals

Cash price vs list price

Median list price (chargemaster)$665
Median cash price$266
Cash as a share of list, median hospital56%

At the typical hospital, asking for the cash price cuts the list price by about 44%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

109 hospitals filed a usable inpatient cash price for this code. The median is $350 and the average of the middle 60% is $527; most fall between $160 and $1,193.

Cash price percentiles, inpatient, across 109 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$140$175$350$1,193$1,210

The most expensive tenth of hospitals charges at least 8.6× what the cheapest tenth charges ($140 vs $1,210).

Of the 110 hospitals that filed this code inpatient, 109 gave a usable cash price; 0 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 1 a list price only.

How complete is this

177 of the 3,956 hospitals with a price file in our corpus (4%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 180 hospitals that filed this code at all gave us
Usable cash price — counted177
Cash price carrying a plausibility flag — shown on the compare tool, excluded here1
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded1
Hospitals that filed this code180

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as TYMS GENE COM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Thymidylate synthase gene test for common variants (CPT 81346) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81346-thymidylate-synthase-gene-test-for-common-variants