HRHospitalRates.comCompare prices

Procedure price report · Pathology

TPMT gene test for common variants affecting drug handling

CPT 81335the billing code this page is about

Laboratory test that checks the TPMT gene for a small set of common changes that influence how the body breaks down certain medicines.

Hospitals typically charge $323 cash for this outpatient procedure — the median across 1,545 hospitals that filed a usable cash price; the average of the middle 60% is $344. Most fall between $175 and $614 (20th–80th percentile).

Hospitals
1,545
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,545 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$146$197$323$539$898

The most expensive tenth of hospitals charges at least 6.2× what the cheapest tenth charges ($146 vs $898).

How the prices are spread

$88 – $114: 25 hospitals$88$114 – $148: 61 hospitals$148 – $192: 182 hospitals$148$192 – $249: 259 hospitals$249 – $323: 170 hospitals$249$323 – $419: 167 hospitals$419 – $544: 223 hospitals$419$544 – $707: 130 hospitals$707 – $918: 112 hospitals$707$918 – $1,192: 64 hospitals$918median $323price bands are equal on a log scale
Hospitals per price band (1,393 of 1,545 — the bands cover the 5th to 95th percentile)
FromToHospitals
$88$11425
$114$14861
$148$192182
$192$249259
$249$323170
$323$419167
$419$544223
$544$707130
$707$918112
$918$1,19264

By state

The median cash price in each state, against the national median of $323.

Alaska: median $621 across 11 hospitalsAK$621Maine: 5 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: median $463 across 18 hospitalsNH$463Washington: median $223 across 32 hospitalsWA$223Idaho: median $222 across 13 hospitalsID$222Montana: 7 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 6 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $247 across 24 hospitalsMN$247Illinois: median $418 across 72 hospitalsIL$418Wisconsin: median $465 across 57 hospitalsWI$465Michigan: median $241 across 41 hospitalsMI$241New York: median $300 across 72 hospitalsNY$300Massachusetts: median $498 across 28 hospitalsMA$498Oregon: median $410 across 27 hospitalsOR$410Nevada: 9 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 6 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 6 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $200 across 27 hospitalsIA$200Indiana: median $334 across 57 hospitalsIN$334Ohio: median $527 across 107 hospitalsOH$527Pennsylvania: median $376 across 79 hospitalsPA$376New Jersey: median $192 across 47 hospitalsNJ$192Connecticut: 9 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 2 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $420 across 70 hospitalsCA$420Utah: median $258 across 30 hospitalsUT$258Colorado: median $332 across 28 hospitalsCO$332Nebraska: median $573 across 19 hospitalsNE$573Missouri: median $386 across 39 hospitalsMO$386Kentucky: median $356 across 37 hospitalsKY$356West Virginia: median $175 across 22 hospitalsWV$175Virginia: median $237 across 42 hospitalsVA$237Maryland: median $173 across 24 hospitalsMD$173Delaware: 4 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $187 across 12 hospitalsAZ$187New Mexico: median $246 across 16 hospitalsNM$246Kansas: median $489 across 20 hospitalsKS$489Arkansas: median $370 across 15 hospitalsAR$370Tennessee: median $220 across 34 hospitalsTN$220North Carolina: median $448 across 34 hospitalsNC$448South Carolina: median $434 across 26 hospitalsSC$434Oklahoma: median $405 across 31 hospitalsOK$405Louisiana: median $194 across 11 hospitalsLA$194Mississippi: median $155 across 16 hospitalsMS$155Alabama: median $342 across 11 hospitalsAL$342Georgia: median $312 across 58 hospitalsGA$312Hawaii: 9 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $330 across 112 hospitalsTX$330Florida: median $350 across 62 hospitalsFL$350
Cash price by state, most expensive first. National median $323. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Alaska AK11$621+92%$400 – $839
Nebraska NE19$573+77%$143 – $731
Ohio OH107$527+63%$280 – $840
Massachusetts MA28$498+54%$248 – $669
Kansas KS20$489+52%$243 – $773
Wisconsin WI57$465+44%$203 – $510
New Hampshire NH18$463+43%$128 – $895
North Carolina NC34$448+39%$118 – $750
South Carolina SC26$434+34%$314 – $550
California CA70$420+30%$77 – $1,210
Illinois IL72$418+29%$220 – $579
Oregon OR27$410+27%$176 – $563
Oklahoma OK31$405+25%$293 – $475
Missouri MO39$386+20%$263 – $565
Pennsylvania PA79$376+17%$201 – $1,010
Arkansas AR15$370+15%$53 – $382
Kentucky KY37$356+10%$195 – $621
Florida FL62$350+8%$175 – $880
Alabama AL11$342+6%$197 – $408
Indiana IN57$334+3%$215 – $469
Colorado CO28$332+3%$210 – $627
Texas TX112$330+2%$185 – $625
Georgia GA58$312−3%$170 – $898
New York NY72$300−7%$175 – $576
Utah UT30$258−20%$220 – $258
Minnesota MN24$247−24%$65 – $427
New Mexico NM16$246−24%$216 – $562
Michigan MI41$241−25%$150 – $411
Virginia VA42$237−27%$221 – $373
Washington WA32$223−31%$193 – $502
Idaho ID13$222−31%$222 – $424
Tennessee TN34$220−32%$150 – $315
Iowa IA27$200−38%$168 – $467
Louisiana LA11$194−40%$136 – $360
New Jersey NJ47$192−40%$175 – $201
Arizona AZ12$187−42%$132 – $442
West Virginia WV22$175−46%$175 – $221
Maryland MD24$173−46%$126 – $478
Mississippi MS16$155−52%$102 – $269
Connecticut CT9not enough hospitals filed a usable price
Hawaii HI9not enough hospitals filed a usable price
Nevada NV9not enough hospitals filed a usable price
Montana MT7not enough hospitals filed a usable price
North Dakota ND6not enough hospitals filed a usable price
South Dakota SD6not enough hospitals filed a usable price
Wyoming WY6not enough hospitals filed a usable price
Maine ME5not enough hospitals filed a usable price
Delaware DE4not enough hospitals filed a usable price
Rhode Island RI2not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $323.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,240$312$175 – $621
Children’s38$248$146 – $565
Critical access261$370$217 – $573
Ownership
For-profit162$360$186 – $719
Government199$304$175 – $650
Non-profit1,178$323$176 – $592
System affiliation
Part of a system1,344$316$175 – $619
Independent201$360$188 – $600

Cash price vs list price

Median list price (chargemaster)$603
Median cash price$323
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,152 hospitals filed a usable inpatient cash price for this code. The median is $361 and the average of the middle 60% is $371; most fall between $196 and $655.

Cash price percentiles, inpatient, across 1,152 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$150$210$361$565$930

The most expensive tenth of hospitals charges at least 6.2× what the cheapest tenth charges ($150 vs $930).

Of the 1,281 hospitals that filed this code inpatient, 1,152 gave a usable cash price; 83 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 46 a list price only.

How complete is this

1,545 of the 3,956 hospitals with a price file in our corpus (39%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,699 hospitals that filed this code at all gave us
Usable cash price — counted1,545
Cash price carrying a plausibility flag — shown on the compare tool, excluded here100
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded53
Hospitals that filed this code1,699

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as TPMT GENE COM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “TPMT gene test for common variants affecting drug handling (CPT 81335) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81335-tpmt-gene-test-for-common-variants-affecting-drug-handling