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Procedure price report · Pathology

SERPINA1 gene test for common alpha-1 antitrypsin variants

CPT 81332the billing code this page is about

Laboratory test that checks the SERPINA1 gene for the common changes associated with alpha-1 antitrypsin deficiency, which can affect the lungs and liver.

Hospitals typically charge $172 cash for this outpatient procedure — the median across 1,334 hospitals that filed a usable cash price; the average of the middle 60% is $189. Most fall between $74 and $373 (20th–80th percentile).

Hospitals
1,334
States
48
Filings dated
Dec 2022 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,334 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$50$89$172$330$551

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($50 vs $551).

How the prices are spread

$44 – $58: 115 hospitals$44$58 – $77: 93 hospitals$77 – $102: 110 hospitals$77$102 – $135: 161 hospitals$135 – $179: 152 hospitals$135$179 – $237: 156 hospitals$237 – $314: 117 hospitals$237$314 – $416: 133 hospitals$416 – $552: 102 hospitals$416$552 – $732: 63 hospitals$552median $172price bands are equal on a log scale
Hospitals per price band (1,202 of 1,334 — the bands cover the 5th to 95th percentile)
FromToHospitals
$44$58115
$58$7793
$77$102110
$102$135161
$135$179152
$179$237156
$237$314117
$314$416133
$416$552102
$552$73263

By state

The median cash price in each state, against the national median of $172.

Alaska: 6 hospitals filed a usable price — fewer than 10, so no figureAKMaine: no hospital in the corpus filed a usable priceMEVermont: 3 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: median $182 across 15 hospitalsNH$182Washington: median $113 across 29 hospitalsWA$113Idaho: median $126 across 12 hospitalsID$126Montana: 2 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $247 across 15 hospitalsMN$247Illinois: median $299 across 60 hospitalsIL$299Wisconsin: median $230 across 29 hospitalsWI$230Michigan: median $57 across 29 hospitalsMI$57New York: median $126 across 56 hospitalsNY$126Massachusetts: median $174 across 28 hospitalsMA$174Oregon: median $118 across 11 hospitalsOR$118Nevada: 9 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 1 hospital filed a usable price — fewer than 10, so no figureWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $128 across 18 hospitalsIA$128Indiana: median $94 across 52 hospitalsIN$94Ohio: median $148 across 92 hospitalsOH$148Pennsylvania: median $218 across 91 hospitalsPA$218New Jersey: median $48 across 41 hospitalsNJ$48Connecticut: 7 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 5 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $224 across 42 hospitalsCA$224Utah: median $373 across 29 hospitalsUT$373Colorado: median $218 across 20 hospitalsCO$218Nebraska: median $245 across 14 hospitalsNE$245Missouri: median $282 across 34 hospitalsMO$282Kentucky: median $244 across 37 hospitalsKY$244West Virginia: median $174 across 11 hospitalsWV$174Virginia: median $164 across 56 hospitalsVA$164Maryland: median $118 across 28 hospitalsMD$118Delaware: 4 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $260 across 20 hospitalsAZ$260New Mexico: 2 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $301 across 19 hospitalsKS$301Arkansas: 7 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $134 across 33 hospitalsTN$134North Carolina: median $90 across 39 hospitalsNC$90South Carolina: median $318 across 27 hospitalsSC$318Oklahoma: median $216 across 22 hospitalsOK$216Louisiana: median $86 across 21 hospitalsLA$86Mississippi: median $67 across 16 hospitalsMS$67Alabama: median $171 across 17 hospitalsAL$171Georgia: median $152 across 49 hospitalsGA$152Hawaii: 7 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $311 across 114 hospitalsTX$311Florida: median $129 across 53 hospitalsFL$129
Cash price by state, most expensive first. National median $172. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT29$373+117%$135 – $439
South Carolina SC27$318+85%$146 – $551
Texas TX114$311+81%$154 – $475
Kansas KS19$301+76%$130 – $557
Illinois IL60$299+74%$77 – $580
Missouri MO34$282+64%$181 – $539
Arizona AZ20$260+51%$64 – $368
Minnesota MN15$247+44%$75 – $247
Nebraska NE14$245+43%$66 – $521
Kentucky KY37$244+42%$123 – $449
Wisconsin WI29$230+34%$156 – $584
California CA42$224+30%$46 – $526
Colorado CO20$218+27%$168 – $1,010
Pennsylvania PA91$218+27%$79 – $480
Oklahoma OK22$216+26%$74 – $216
New Hampshire NH15$182+6%$108 – $301
Massachusetts MA28$174+1%$89 – $247
West Virginia WV11$174+1%$153 – $420
Alabama AL17$171−1%$50 – $290
Virginia VA56$164−4%$51 – $440
Georgia GA49$152−12%$96 – $200
Ohio OH92$148−14%$104 – $196
Tennessee TN33$134−22%$82 – $199
Florida FL53$129−25%$61 – $292
Iowa IA18$128−25%$128 – $279
Idaho ID12$126−26%$126 – $373
New York NY56$126−27%$44 – $212
Maryland MD28$118−31%$88 – $204
Oregon OR11$118−31%$48 – $240
Washington WA29$113−34%$69 – $288
Indiana IN52$94−45%$62 – $358
North Carolina NC39$90−48%$71 – $183
Louisiana LA21$86−50%$60 – $255
Mississippi MS16$67−61%$32 – $305
Michigan MI29$57−67%$52 – $109
New Jersey NJ41$48−72%$44 – $93
Nevada NV9not enough hospitals filed a usable price
Arkansas AR7not enough hospitals filed a usable price
Connecticut CT7not enough hospitals filed a usable price
Hawaii HI7not enough hospitals filed a usable price
Alaska AK6not enough hospitals filed a usable price
Rhode Island RI5not enough hospitals filed a usable price
Delaware DE4not enough hospitals filed a usable price
Vermont VT3not enough hospitals filed a usable price
Montana MT2not enough hospitals filed a usable price
North Dakota ND2not enough hospitals filed a usable price
New Mexico NM2not enough hospitals filed a usable price
Wyoming WY1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $172.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,080$160$68 – $359
Children’s40$222$97 – $350
Critical access210$207$113 – $434
Ownership
For-profit169$192$84 – $548
Government169$174$71 – $357
Non-profit992$166$74 – $373
System affiliation
Part of a system1,133$168$72 – $373
Independent201$177$90 – $401

Cash price vs list price

Median list price (chargemaster)$301
Median cash price$172
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

963 hospitals filed a usable inpatient cash price for this code. The median is $175 and the average of the middle 60% is $195; most fall between $81 and $373.

Cash price percentiles, inpatient, across 963 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$56$96$175$335$526

The most expensive tenth of hospitals charges at least 9.4× what the cheapest tenth charges ($56 vs $526).

Of the 1,061 hospitals that filed this code inpatient, 963 gave a usable cash price; 46 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 52 a list price only.

How complete is this

1,334 of the 3,956 hospitals with a price file in our corpus (34%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,477 hospitals that filed this code at all gave us
Usable cash price — counted1,334
Cash price carrying a plausibility flag — shown on the compare tool, excluded here79
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded63
Hospitals that filed this code1,477

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between July 20, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as SERPINA1 GENE.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “SERPINA1 gene test for common alpha-1 antitrypsin variants (CPT 81332) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81332-serpina1-gene-test-for-common-alpha-1-antitrypsin-variants