HRHospitalRates.comCompare prices

Procedure price report · Pathology

Methylation test for Prader-Willi and Angelman syndromes

CPT 81331the billing code this page is about

Laboratory test that examines methylation patterns in the SNRPN/UBE3A chromosome region used in evaluating these two genetic syndromes.

Hospitals typically charge $264 cash for this outpatient procedure — the median across 1,262 hospitals that filed a usable cash price; the average of the middle 60% is $289. Most fall between $116 and $553 (20th–80th percentile).

Hospitals
1,262
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,262 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$70$137$264$471$817

The most expensive tenth of hospitals charges at least 12× what the cheapest tenth charges ($70 vs $817).

How the prices are spread

$56 – $78: 106 hospitals$56$78 – $109: 62 hospitals$109 – $151: 126 hospitals$109$151 – $210: 148 hospitals$210 – $292: 156 hospitals$210$292 – $405: 195 hospitals$405 – $563: 161 hospitals$405$563 – $783: 98 hospitals$783 – $1,088: 53 hospitals$783$1,088 – $1,513: 31 hospitals$1,088median $264price bands are equal on a log scale
Hospitals per price band (1,136 of 1,262 — the bands cover the 5th to 95th percentile)
FromToHospitals
$56$78106
$78$10962
$109$151126
$151$210148
$210$292156
$292$405195
$405$563161
$563$78398
$783$1,08853
$1,088$1,51331

By state

The median cash price in each state, against the national median of $264.

Alaska: 5 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: 4 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $183 across 29 hospitalsWA$183Idaho: median $431 across 11 hospitalsID$431Montana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 5 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $440 across 39 hospitalsMN$440Illinois: median $510 across 49 hospitalsIL$510Wisconsin: median $450 across 54 hospitalsWI$450Michigan: median $200 across 56 hospitalsMI$200New York: median $125 across 63 hospitalsNY$125Massachusetts: median $143 across 24 hospitalsMA$143Oregon: median $256 across 10 hospitalsOR$256Nevada: 8 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 3 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 4 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $128 across 20 hospitalsIA$128Indiana: median $116 across 32 hospitalsIN$116Ohio: median $285 across 82 hospitalsOH$285Pennsylvania: median $649 across 38 hospitalsPA$649New Jersey: median $56 across 41 hospitalsNJ$56Connecticut: 8 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 3 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $167 across 55 hospitalsCA$167Utah: median $379 across 24 hospitalsUT$379Colorado: median $438 across 24 hospitalsCO$438Nebraska: 6 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $340 across 35 hospitalsMO$340Kentucky: median $392 across 18 hospitalsKY$392West Virginia: median $178 across 13 hospitalsWV$178Virginia: median $195 across 40 hospitalsVA$195Maryland: median $306 across 27 hospitalsMD$306Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $131 across 12 hospitalsAZ$131New Mexico: 7 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $937 across 15 hospitalsKS$937Arkansas: median $337 across 11 hospitalsAR$337Tennessee: median $74 across 21 hospitalsTN$74North Carolina: median $228 across 57 hospitalsNC$228South Carolina: median $471 across 17 hospitalsSC$471Oklahoma: median $310 across 38 hospitalsOK$310Louisiana: median $72 across 24 hospitalsLA$72Mississippi: median $180 across 19 hospitalsMS$180Alabama: median $563 across 11 hospitalsAL$563Georgia: median $460 across 51 hospitalsGA$460Hawaii: 4 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $335 across 96 hospitalsTX$335Florida: median $120 across 43 hospitalsFL$120
Cash price by state, most expensive first. National median $264. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Kansas KS15$937+255%$177 – $1,097
Pennsylvania PA38$649+146%$42 – $1,737
Alabama AL11$563+113%$250 – $825
Illinois IL49$510+93%$118 – $1,173
South Carolina SC17$471+79%$471 – $804
Georgia GA51$460+74%$185 – $2,347
Wisconsin WI54$450+70%$153 – $632
Minnesota MN39$440+67%$336 – $463
Colorado CO24$438+66%$199 – $605
Idaho ID11$431+63%$379 – $593
Kentucky KY18$392+48%$195 – $1,719
Utah UT24$379+43%$379 – $445
Missouri MO35$340+29%$210 – $541
Arkansas AR11$337+28%$45 – $398
Texas TX96$335+27%$139 – $661
Oklahoma OK38$310+17%$97 – $479
Maryland MD27$306+16%$225 – $383
Ohio OH82$285+8%$243 – $679
Oregon OR10$256−3%$132 – $256
North Carolina NC57$228−14%$105 – $355
Michigan MI56$200−24%$106 – $358
Virginia VA40$195−26%$139 – $478
Washington WA29$183−31%$77 – $317
Mississippi MS19$180−32%$68 – $325
West Virginia WV13$178−33%$178 – $255
California CA55$167−37%$152 – $198
Massachusetts MA24$143−46%$57 – $617
Arizona AZ12$131−50%$59 – $338
Iowa IA20$128−52%$128 – $552
New York NY63$125−52%$52 – $387
Florida FL43$120−55%$111 – $500
Indiana IN32$116−56%$74 – $384
Tennessee TN21$74−72%$74 – $232
Louisiana LA24$72−73%$49 – $313
New Jersey NJ41$56−79%$51 – $246
Connecticut CT8not enough hospitals filed a usable price
Nevada NV8not enough hospitals filed a usable price
New Mexico NM7not enough hospitals filed a usable price
Nebraska NE6not enough hospitals filed a usable price
Alaska AK5not enough hospitals filed a usable price
North Dakota ND5not enough hospitals filed a usable price
Hawaii HI4not enough hospitals filed a usable price
New Hampshire NH4not enough hospitals filed a usable price
South Dakota SD4not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
Rhode Island RI3not enough hospitals filed a usable price
Wyoming WY3not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $264.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care993$243$106 – $529
Children’s43$400$211 – $774
Critical access221$369$170 – $521
Ownership
For-profit117$338$120 – $1,236
Government165$291$110 – $586
Non-profit975$256$113 – $521
System affiliation
Part of a system1,125$256$111 – $529
Independent137$314$150 – $623

Cash price vs list price

Median list price (chargemaster)$461
Median cash price$264
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

898 hospitals filed a usable inpatient cash price for this code. The median is $314 and the average of the middle 60% is $315; most fall between $142 and $563.

Cash price percentiles, inpatient, across 898 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$87$163$314$478$810

The most expensive tenth of hospitals charges at least 9.3× what the cheapest tenth charges ($87 vs $810).

Of the 1,005 hospitals that filed this code inpatient, 898 gave a usable cash price; 69 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 38 a list price only.

How complete is this

1,262 of the 3,956 hospitals with a price file in our corpus (32%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,391 hospitals that filed this code at all gave us
Usable cash price — counted1,262
Cash price carrying a plausibility flag — shown on the compare tool, excluded here86
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded42
Hospitals that filed this code1,391

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as METHYLATION ANALYSIS (SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE N AND UBIQUITIN PROTEIN LIGASE E3A).

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Methylation test for Prader-Willi and Angelman syndromes (CPT 81331) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81331-methylation-test-for-prader-willi-and-angelman-syndromes