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Procedure price report · Pathology

Full gene sequencing of the PTEN gene

CPT 81321the billing code this page is about

Laboratory test that reads the entire coding sequence of the PTEN gene, associated with inherited tumor and cancer risk syndromes.

Hospitals typically charge $720 cash for this outpatient procedure — the median across 703 hospitals that filed a usable cash price; the average of the middle 60% is $796. Most fall between $278 and $1,709 (20th–80th percentile).

Hospitals
703
States
47
Filings dated
Mar 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 703 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$162$413$720$1,305$2,946

The most expensive tenth of hospitals charges at least 18× what the cheapest tenth charges ($162 vs $2,946).

How the prices are spread

$92 – $134: 29 hospitals$92$134 – $195: 36 hospitals$195 – $283: 43 hospitals$195$283 – $410: 34 hospitals$410 – $595: 111 hospitals$410$595 – $864: 115 hospitals$864 – $1,254: 114 hospitals$864$1,254 – $1,821: 69 hospitals$1,821 – $2,643: 40 hospitals$1,821$2,643 – $3,836: 49 hospitals$2,643median $720price bands are equal on a log scale
Hospitals per price band (640 of 703 — the bands cover the 5th to 95th percentile)
FromToHospitals
$92$13429
$134$19536
$195$28343
$283$41034
$410$595111
$595$864115
$864$1,254114
$1,254$1,82169
$1,821$2,64340
$2,643$3,83649

By state

The median cash price in each state, against the national median of $720.

Alaska: 3 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 2 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: 2 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $893 across 20 hospitalsWA$893Idaho: 2 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $77 across 13 hospitalsMN$77Illinois: median $1,022 across 31 hospitalsIL$1,022Wisconsin: median $1,307 across 29 hospitalsWI$1,307Michigan: median $828 across 13 hospitalsMI$828New York: median $720 across 37 hospitalsNY$720Massachusetts: median $1,800 across 17 hospitalsMA$1,800Oregon: median $720 across 13 hospitalsOR$720Nevada: 5 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $576 across 12 hospitalsIA$576Indiana: median $720 across 27 hospitalsIN$720Ohio: median $976 across 60 hospitalsOH$976Pennsylvania: median $399 across 25 hospitalsPA$399New Jersey: median $660 across 31 hospitalsNJ$660Connecticut: 5 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $3,836 across 32 hospitalsCA$3,836Utah: 1 hospital filed a usable price — fewer than 10, so no figureUTColorado: 4 hospitals filed a usable price — fewer than 10, so no figureCONebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $1,188 across 13 hospitalsMO$1,188Kentucky: median $900 across 18 hospitalsKY$900West Virginia: median $126 across 16 hospitalsWV$126Virginia: median $3,690 across 17 hospitalsVA$3,690Maryland: median $749 across 15 hospitalsMD$749Delaware: 4 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 9 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 2 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 7 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 4 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $472 across 24 hospitalsTN$472North Carolina: 8 hospitals filed a usable price — fewer than 10, so no figureNCSouth Carolina: median $1,069 across 22 hospitalsSC$1,069Oklahoma: median $473 across 12 hospitalsOK$473Louisiana: 8 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: median $425 across 17 hospitalsMS$425Alabama: 2 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $1,909 across 25 hospitalsGA$1,909Hawaii: 2 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $390 across 69 hospitalsTX$390Florida: median $385 across 18 hospitalsFL$385
Cash price by state, most expensive first. National median $720. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA32$3,836+433%$135 – $3,836
Virginia VA17$3,690+412%$472 – $4,269
Georgia GA25$1,909+165%$433 – $2,259
Massachusetts MA17$1,800+150%$1,262 – $2,088
Wisconsin WI29$1,307+82%$78 – $4,820
Missouri MO13$1,188+65%$901 – $1,789
South Carolina SC22$1,069+48%$486 – $1,684
Illinois IL31$1,022+42%$576 – $1,296
Ohio OH60$976+36%$508 – $3,489
Kentucky KY18$900+25%$506 – $992
Washington WA20$893+24%$661 – $1,305
Michigan MI13$828+15%$139 – $836
Maryland MD15$749+4%$549 – $870
Indiana IN27$7200%$206 – $900
New York NY37$7200%$600 – $1,759
Oregon OR13$7200%$569 – $1,663
New Jersey NJ31$660−8%$460 – $2,595
Iowa IA12$576−20%$576 – $576
Oklahoma OK12$473−34%$324 – $611
Tennessee TN24$472−34%$466 – $780
Mississippi MS17$425−41%$226 – $830
Pennsylvania PA25$399−45%$47 – $1,122
Texas TX69$390−46%$258 – $1,020
Florida FL18$385−47%$194 – $600
West Virginia WV16$126−82%$126 – $126
Minnesota MN13$77−89%$77 – $176
Arizona AZ9not enough hospitals filed a usable price
Louisiana LA8not enough hospitals filed a usable price
North Carolina NC8not enough hospitals filed a usable price
Kansas KS7not enough hospitals filed a usable price
Connecticut CT5not enough hospitals filed a usable price
Nevada NV5not enough hospitals filed a usable price
Arkansas AR4not enough hospitals filed a usable price
Colorado CO4not enough hospitals filed a usable price
Delaware DE4not enough hospitals filed a usable price
Alaska AK3not enough hospitals filed a usable price
North Dakota ND3not enough hospitals filed a usable price
Alabama AL2not enough hospitals filed a usable price
Hawaii HI2not enough hospitals filed a usable price
Idaho ID2not enough hospitals filed a usable price
Maine ME2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
New Hampshire NH2not enough hospitals filed a usable price
New Mexico NM2not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
Utah UT1not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $720.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care571$709$317 – $1,715
Children’s32$508$230 – $1,141
Critical access97$830$258 – $1,809
Ownership
For-profit49$883$258 – $1,872
Government77$600$291 – $1,260
Non-profit574$730$258 – $1,710
System affiliation
Part of a system620$731$283 – $1,736
Independent83$683$250 – $1,558

Cash price vs list price

Median list price (chargemaster)$1,460
Median cash price$720
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

506 hospitals filed a usable inpatient cash price for this code. The median is $768 and the average of the middle 60% is $849; most fall between $324 and $1,800.

Cash price percentiles, inpatient, across 506 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$173$415$768$1,637$3,489

The most expensive tenth of hospitals charges at least 20× what the cheapest tenth charges ($173 vs $3,489).

Of the 625 hospitals that filed this code inpatient, 506 gave a usable cash price; 93 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 26 a list price only.

How complete is this

703 of the 3,956 hospitals with a price file in our corpus (18%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 834 hospitals that filed this code at all gave us
Usable cash price — counted703
Cash price carrying a plausibility flag — shown on the compare tool, excluded here106
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded24
Hospitals that filed this code834

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as HC Pten Ngs.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Full gene sequencing of the PTEN gene (CPT 81321) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81321-full-gene-sequencing-of-the-pten-gene