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Procedure price report · Pathology

Alpha globin gene test for a known family variant

CPT 81258the billing code this page is about

A laboratory test that checks the alpha globin genes only for a specific change already found in a relative.

Hospitals typically charge $482 cash for this outpatient procedure — the median across 185 hospitals that filed a usable cash price; the average of the middle 60% is $564. Most fall between $375 and $857 (20th–80th percentile).

Hospitals
185
States
26
Filings dated
Oct 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 23, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 185 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$368$413$482$827$1,051

The most expensive tenth of hospitals charges at least 2.9× what the cheapest tenth charges ($368 vs $1,051).

How the prices are spread

$307 – $350: 6 hospitals$307$350 – $400: 28 hospitals$400 – $456: 43 hospitals$400$456 – $521: 17 hospitals$521 – $594: 9 hospitals$521$594 – $678: 4 hospitals$678 – $774: 15 hospitals$678$774 – $883: 29 hospitals$883 – $1,008: 5 hospitals$883$1,008 – $1,151: 15 hospitals$1,008median $482price bands are equal on a log scale
Hospitals per price band (171 of 185 — the bands cover the 5th to 95th percentile)
FromToHospitals
$307$3506
$350$40028
$400$45643
$456$52117
$521$5949
$594$6784
$678$77415
$774$88329
$883$1,0085
$1,008$1,15115

By state

The median cash price in each state, against the national median of $482.

Alaska: no hospital in the corpus filed a usable priceAKMaine: no hospital in the corpus filed a usable priceMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: 3 hospitals filed a usable price — fewer than 10, so no figureWAIdaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: median $440 across 10 hospitalsMN$440Illinois: 3 hospitals filed a usable price — fewer than 10, so no figureILWisconsin: 7 hospitals filed a usable price — fewer than 10, so no figureWIMichigan: median $442 across 12 hospitalsMI$442New York: median $375 across 12 hospitalsNY$375Massachusetts: 1 hospital filed a usable price — fewer than 10, so no figureMAOregon: 2 hospitals filed a usable price — fewer than 10, so no figureORNevada: 3 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $751 across 11 hospitalsIA$751Indiana: median $416 across 12 hospitalsIN$416Ohio: median $827 across 25 hospitalsOH$827Pennsylvania: median $259 across 10 hospitalsPA$259New Jersey: median $413 across 22 hospitalsNJ$413Connecticut: no hospital in the corpus filed a usable priceCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $857 across 20 hospitalsCA$857Utah: no hospital in the corpus filed a usable priceUTColorado: 2 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: 2 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: 1 hospital filed a usable price — fewer than 10, so no figureKYWest Virginia: no hospital in the corpus filed a usable priceWVVirginia: 8 hospitals filed a usable price — fewer than 10, so no figureVAMaryland: no hospital in the corpus filed a usable priceMDDelaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: 2 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: no hospital in the corpus filed a usable priceKSArkansas: no hospital in the corpus filed a usable priceARTennessee: 7 hospitals filed a usable price — fewer than 10, so no figureTNNorth Carolina: no hospital in the corpus filed a usable priceNCSouth Carolina: no hospital in the corpus filed a usable priceSCOklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 2 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: no hospital in the corpus filed a usable priceMSAlabama: no hospital in the corpus filed a usable priceALGeorgia: no hospital in the corpus filed a usable priceGAHawaii: no hospital in the corpus filed a usable priceHITexas: 2 hospitals filed a usable price — fewer than 10, so no figureTXFlorida: 3 hospitals filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $482. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA20$857+78%$857 – $857
Ohio OH25$827+72%$745 – $1,151
Iowa IA11$751+56%$751 – $751
Michigan MI12$442−8%$442 – $518
Minnesota MN10$440−9%$375 – $440
Indiana IN12$416−14%$366 – $562
New Jersey NJ22$413−14%$375 – $413
New York NY12$375−22%$375 – $375
Pennsylvania PA10$259−46%$214 – $293
Virginia VA8not enough hospitals filed a usable price
Tennessee TN7not enough hospitals filed a usable price
Wisconsin WI7not enough hospitals filed a usable price
Florida FL3not enough hospitals filed a usable price
Illinois IL3not enough hospitals filed a usable price
Nevada NV3not enough hospitals filed a usable price
Washington WA3not enough hospitals filed a usable price
Arizona AZ2not enough hospitals filed a usable price
Colorado CO2not enough hospitals filed a usable price
Louisiana LA2not enough hospitals filed a usable price
Missouri MO2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Oregon OR2not enough hospitals filed a usable price
Texas TX2not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price
Kentucky KY1not enough hospitals filed a usable price
Massachusetts MA1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $482.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care149$488$375 – $857
Children’s5fewer than 20 hospitals
Critical access27$450$440 – $591
Ownership
For-profit5fewer than 20 hospitals
Government20$375$375 – $482
Non-profit156$482$375 – $857
System affiliation
Part of a system171$482$375 – $857
Independent14fewer than 20 hospitals

Cash price vs list price

Median list price (chargemaster)$1,179
Median cash price$482
Cash as a share of list, median hospital56%

At the typical hospital, asking for the cash price cuts the list price by about 44%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

123 hospitals filed a usable inpatient cash price for this code. The median is $751 and the average of the middle 60% is $692; most fall between $442 and $937.

Cash price percentiles, inpatient, across 123 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$440$450$751$857$1,126

The most expensive tenth of hospitals charges at least 2.6× what the cheapest tenth charges ($440 vs $1,126).

Of the 124 hospitals that filed this code inpatient, 123 gave a usable cash price; 0 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 1 a list price only.

How complete is this

185 of the 3,956 hospitals with a price file in our corpus (5%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 189 hospitals that filed this code at all gave us
Usable cash price — counted185
Cash price carrying a plausibility flag — shown on the compare tool, excluded here2
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded1
Hospitals that filed this code189

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 5, 2026 and September 23, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as HBA1/HBA2 GENE FAM VRNT.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Alpha globin gene test for a known family variant (CPT 81258) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81258-alpha-globin-gene-test-for-a-known-family-variant