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Procedure price report · Pathology

CYP2C9 drug-processing gene test, common variants

CPT 81227the billing code this page is about

A genetic test of the CYP2C9 gene that checks for the common variants affecting how the body breaks down certain medicines.

Hospitals typically charge $262 cash for this outpatient procedure — the median across 968 hospitals that filed a usable cash price; the average of the middle 60% is $297. Most fall between $140 and $551 (20th–80th percentile).

Hospitals
968
States
49
Filings dated
Dec 2023 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 968 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$82$160$262$527$1,103

The most expensive tenth of hospitals charges at least 13× what the cheapest tenth charges ($82 vs $1,103).

How the prices are spread

$60 – $83: 52 hospitals$60$83 – $114: 22 hospitals$114 – $156: 116 hospitals$114$156 – $215: 144 hospitals$215 – $296: 159 hospitals$215$296 – $408: 126 hospitals$408 – $561: 116 hospitals$408$561 – $772: 41 hospitals$772 – $1,063: 42 hospitals$772$1,063 – $1,463: 57 hospitals$1,063median $262price bands are equal on a log scale
Hospitals per price band (875 of 968 — the bands cover the 5th to 95th percentile)
FromToHospitals
$60$8352
$83$11422
$114$156116
$156$215144
$215$296159
$296$408126
$408$561116
$561$77241
$772$1,06342
$1,063$1,46357

By state

The median cash price in each state, against the national median of $262.

Alaska: 4 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 3 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: median $257 across 27 hospitalsWA$257Idaho: 2 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 1 hospital filed a usable price — fewer than 10, so no figureMTNorth Dakota: 8 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $528 across 36 hospitalsMN$528Illinois: median $341 across 37 hospitalsIL$341Wisconsin: median $540 across 37 hospitalsWI$540Michigan: median $241 across 31 hospitalsMI$241New York: median $175 across 33 hospitalsNY$175Massachusetts: median $495 across 23 hospitalsMA$495Oregon: 9 hospitals filed a usable price — fewer than 10, so no figureORNevada: median $255 across 10 hospitalsNV$255Wyoming: 4 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 4 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $168 across 20 hospitalsIA$168Indiana: median $204 across 38 hospitalsIN$204Ohio: median $329 across 79 hospitalsOH$329Pennsylvania: median $376 across 51 hospitalsPA$376New Jersey: median $192 across 38 hospitalsNJ$192Connecticut: 8 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 2 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $1,210 across 28 hospitalsCA$1,210Utah: 2 hospitals filed a usable price — fewer than 10, so no figureUTColorado: median $389 across 22 hospitalsCO$389Nebraska: 6 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $290 across 13 hospitalsMO$290Kentucky: median $164 across 21 hospitalsKY$164West Virginia: median $200 across 14 hospitalsWV$200Virginia: median $239 across 35 hospitalsVA$239Maryland: median $1,103 across 13 hospitalsMD$1,103Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 7 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 9 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 4 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: 4 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $225 across 16 hospitalsTN$225North Carolina: median $232 across 33 hospitalsNC$232South Carolina: median $375 across 17 hospitalsSC$375Oklahoma: median $319 across 13 hospitalsOK$319Louisiana: median $161 across 15 hospitalsLA$161Mississippi: median $214 across 20 hospitalsMS$214Alabama: 7 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $256 across 37 hospitalsGA$256Hawaii: 7 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $75 across 77 hospitalsTX$75Florida: median $117 across 39 hospitalsFL$117
Cash price by state, most expensive first. National median $262. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA28$1,210+361%$140 – $1,210
Maryland MD13$1,103+321%$63 – $1,504
Wisconsin WI37$540+106%$523 – $549
Minnesota MN36$528+101%$139 – $528
Massachusetts MA23$495+89%$229 – $895
Colorado CO22$389+48%$162 – $618
Pennsylvania PA51$376+44%$174 – $1,565
South Carolina SC17$375+43%$375 – $408
Illinois IL37$341+30%$168 – $424
Ohio OH79$329+25%$290 – $1,015
Oklahoma OK13$319+22%$319 – $462
Missouri MO13$290+11%$139 – $383
Washington WA27$257−2%$192 – $499
Georgia GA37$256−3%$113 – $1,084
Nevada NV10$255−3%$95 – $612
Michigan MI31$241−8%$136 – $312
Virginia VA35$239−9%$133 – $355
North Carolina NC33$232−12%$144 – $262
Tennessee TN16$225−14%$150 – $225
Mississippi MS20$214−19%$137 – $246
Indiana IN38$204−22%$123 – $334
West Virginia WV14$200−24%$200 – $874
New Jersey NJ38$192−27%$175 – $961
New York NY33$175−33%$175 – $426
Iowa IA20$168−36%$168 – $231
Kentucky KY21$164−38%$122 – $290
Louisiana LA15$161−39%$81 – $414
Florida FL39$117−56%$25 – $230
Texas TX77$75−71%$37 – $295
New Mexico NM9not enough hospitals filed a usable price
Oregon OR9not enough hospitals filed a usable price
Connecticut CT8not enough hospitals filed a usable price
North Dakota ND8not enough hospitals filed a usable price
Alabama AL7not enough hospitals filed a usable price
Arizona AZ7not enough hospitals filed a usable price
Hawaii HI7not enough hospitals filed a usable price
Nebraska NE6not enough hospitals filed a usable price
Alaska AK4not enough hospitals filed a usable price
Arkansas AR4not enough hospitals filed a usable price
Kansas KS4not enough hospitals filed a usable price
South Dakota SD4not enough hospitals filed a usable price
Wyoming WY4not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
Maine ME3not enough hospitals filed a usable price
Idaho ID2not enough hospitals filed a usable price
Rhode Island RI2not enough hospitals filed a usable price
Utah UT2not enough hospitals filed a usable price
Montana MT1not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $262.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care775$245$133 – $568
Children’s23$187$66 – $344
Critical access166$355$221 – $549
Ownership
For-profit87$275$118 – $761
Government117$246$143 – $502
Non-profit760$266$140 – $550
System affiliation
Part of a system854$262$140 – $567
Independent114$262$120 – $502

Cash price vs list price

Median list price (chargemaster)$525
Median cash price$262
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

685 hospitals filed a usable inpatient cash price for this code. The median is $290 and the average of the middle 60% is $318; most fall between $136 and $612.

Cash price percentiles, inpatient, across 685 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$75$160$290$549$1,186

The most expensive tenth of hospitals charges at least 16× what the cheapest tenth charges ($75 vs $1,186).

Of the 780 hospitals that filed this code inpatient, 685 gave a usable cash price; 64 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 31 a list price only.

How complete is this

968 of the 3,956 hospitals with a price file in our corpus (24%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,077 hospitals that filed this code at all gave us
Usable cash price — counted968
Cash price carrying a plausibility flag — shown on the compare tool, excluded here76
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded33
Hospitals that filed this code1,077

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as CYP2C9 GENE COM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “CYP2C9 drug-processing gene test, common variants (CPT 81227) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81227-cyp2c9-drug-processing-gene-test-common-variants