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Procedure price report · Pathology

CYP2D6 drug-processing gene test, common variants

CPT 81226the billing code this page is about

A genetic test of the CYP2D6 gene that checks for the common variants affecting how the body breaks down certain medicines.

Hospitals typically charge $509 cash for this outpatient procedure — the median across 1,004 hospitals that filed a usable cash price; the average of the middle 60% is $556. Most fall between $223 and $1,051 (20th–80th percentile).

Hospitals
1,004
States
49
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,004 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$119$273$509$920$1,756

The most expensive tenth of hospitals charges at least 15× what the cheapest tenth charges ($119 vs $1,756).

How the prices are spread

$75 – $106: 47 hospitals$75$106 – $150: 51 hospitals$150 – $211: 31 hospitals$150$211 – $298: 112 hospitals$298 – $421: 108 hospitals$298$421 – $595: 191 hospitals$595 – $840: 142 hospitals$595$840 – $1,187: 102 hospitals$1,187 – $1,676: 82 hospitals$1,187$1,676 – $2,368: 55 hospitals$1,676median $509price bands are equal on a log scale
Hospitals per price band (921 of 1,004 — the bands cover the 5th to 95th percentile)
FromToHospitals
$75$10647
$106$15051
$150$21131
$211$298112
$298$421108
$421$595191
$595$840142
$840$1,187102
$1,187$1,67682
$1,676$2,36855

By state

The median cash price in each state, against the national median of $509.

Alaska: 6 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: 3 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $721 across 31 hospitalsWA$721Idaho: 5 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 3 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 7 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $230 across 31 hospitalsMN$230Illinois: median $1,042 across 53 hospitalsIL$1,042Wisconsin: median $1,033 across 43 hospitalsWI$1,033Michigan: median $349 across 20 hospitalsMI$349New York: median $451 across 40 hospitalsNY$451Massachusetts: median $1,200 across 21 hospitalsMA$1,200Oregon: median $542 across 11 hospitalsOR$542Nevada: 6 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 5 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $433 across 16 hospitalsIA$433Indiana: median $508 across 40 hospitalsIN$508Ohio: median $509 across 91 hospitalsOH$509Pennsylvania: median $269 across 48 hospitalsPA$269New Jersey: median $451 across 32 hospitalsNJ$451Connecticut: 9 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 2 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $3,063 across 30 hospitalsCA$3,063Utah: median $614 across 28 hospitalsUT$614Colorado: median $541 across 15 hospitalsCO$541Nebraska: 6 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $677 across 15 hospitalsMO$677Kentucky: median $265 across 21 hospitalsKY$265West Virginia: median $185 across 11 hospitalsWV$185Virginia: median $634 across 27 hospitalsVA$634Maryland: median $615 across 15 hospitalsMD$615Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 6 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 6 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $1,160 across 11 hospitalsKS$1,160Arkansas: 5 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $586 across 23 hospitalsTN$586North Carolina: median $604 across 25 hospitalsNC$604South Carolina: median $487 across 19 hospitalsSC$487Oklahoma: median $311 across 13 hospitalsOK$311Louisiana: median $420 across 10 hospitalsLA$420Mississippi: median $420 across 23 hospitalsMS$420Alabama: 6 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $218 across 46 hospitalsGA$218Hawaii: 3 hospitals filed a usable price — fewer than 10, so no figureHITexas: median $180 across 65 hospitalsTX$180Florida: median $350 across 45 hospitalsFL$350
Cash price by state, most expensive first. National median $509. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
California CA30$3,063+502%$130 – $3,063
Massachusetts MA21$1,200+136%$645 – $1,431
Kansas KS11$1,160+128%$475 – $1,658
Illinois IL53$1,042+105%$493 – $1,804
Wisconsin WI43$1,033+103%$535 – $1,349
Washington WA31$721+42%$496 – $1,285
Missouri MO15$677+33%$139 – $1,015
Virginia VA27$634+25%$111 – $1,612
Maryland MD15$615+21%$63 – $3,357
Utah UT28$614+21%$614 – $723
North Carolina NC25$604+19%$228 – $720
Tennessee TN23$586+15%$232 – $678
Oregon OR11$542+6%$542 – $980
Colorado CO15$541+6%$73 – $592
Ohio OH91$5090%$371 – $1,387
Indiana IN40$5080%$356 – $742
South Carolina SC19$487−4%$487 – $918
New Jersey NJ32$451−11%$450 – $496
New York NY40$451−11%$419 – $1,322
Iowa IA16$433−15%$414 – $433
Mississippi MS23$420−17%$239 – $623
Louisiana LA10$420−17%$210 – $1,138
Florida FL45$350−31%$25 – $428
Michigan MI20$349−31%$135 – $1,033
Oklahoma OK13$311−39%$276 – $966
Pennsylvania PA48$269−47%$175 – $519
Kentucky KY21$265−48%$122 – $506
Minnesota MN31$230−55%$139 – $460
Georgia GA46$218−57%$218 – $877
West Virginia WV11$185−64%$185 – $554
Texas TX65$180−65%$75 – $676
Connecticut CT9not enough hospitals filed a usable price
North Dakota ND7not enough hospitals filed a usable price
Alaska AK6not enough hospitals filed a usable price
Alabama AL6not enough hospitals filed a usable price
Arizona AZ6not enough hospitals filed a usable price
Nebraska NE6not enough hospitals filed a usable price
New Mexico NM6not enough hospitals filed a usable price
Nevada NV6not enough hospitals filed a usable price
Arkansas AR5not enough hospitals filed a usable price
Idaho ID5not enough hospitals filed a usable price
Wyoming WY5not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
Hawaii HI3not enough hospitals filed a usable price
Montana MT3not enough hospitals filed a usable price
New Hampshire NH3not enough hospitals filed a usable price
South Dakota SD3not enough hospitals filed a usable price
Rhode Island RI2not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $509.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care794$496$217 – $1,042
Children’s24$496$74 – $789
Critical access180$686$370 – $1,257
Ownership
For-profit85$545$210 – $1,152
Government128$519$232 – $973
Non-profit785$506$227 – $1,121
System affiliation
Part of a system860$506$222 – $1,042
Independent144$541$226 – $1,160

Cash price vs list price

Median list price (chargemaster)$912
Median cash price$509
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

726 hospitals filed a usable inpatient cash price for this code. The median is $509 and the average of the middle 60% is $532; most fall between $218 and $1,039.

Cash price percentiles, inpatient, across 726 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$118$261$509$895$1,731

The most expensive tenth of hospitals charges at least 15× what the cheapest tenth charges ($118 vs $1,731).

Of the 828 hospitals that filed this code inpatient, 726 gave a usable cash price; 61 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 41 a list price only.

How complete is this

1,004 of the 3,956 hospitals with a price file in our corpus (25%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,124 hospitals that filed this code at all gave us
Usable cash price — counted1,004
Cash price carrying a plausibility flag — shown on the compare tool, excluded here77
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded42
Hospitals that filed this code1,124

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as CYP2D6 GENE COM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “CYP2D6 drug-processing gene test, common variants (CPT 81226) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81226-cyp2d6-drug-processing-gene-test-common-variants