HRHospitalRates.comCompare prices

Procedure price report · Pathology

CYP2C19 drug-processing gene test, common variants

CPT 81225the billing code this page is about

A genetic test of the CYP2C19 gene that checks for the common variants affecting how the body breaks down certain medicines.

Hospitals typically charge $420 cash for this outpatient procedure — the median across 1,500 hospitals that filed a usable cash price; the average of the middle 60% is $441. Most fall between $195 and $853 (20th–80th percentile).

Hospitals
1,500
States
50
Filings dated
Dec 2023 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,500 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$130$239$420$700$1,165

The most expensive tenth of hospitals charges at least 9.0× what the cheapest tenth charges ($130 vs $1,165).

How the prices are spread

$77 – $105: 30 hospitals$77$105 – $142: 89 hospitals$142 – $193: 95 hospitals$142$193 – $262: 125 hospitals$262 – $355: 240 hospitals$262$355 – $482: 205 hospitals$482 – $654: 215 hospitals$482$654 – $887: 170 hospitals$887 – $1,202: 113 hospitals$887$1,202 – $1,631: 69 hospitals$1,202median $420price bands are equal on a log scale
Hospitals per price band (1,351 of 1,500 — the bands cover the 5th to 95th percentile)
FromToHospitals
$77$10530
$105$14289
$142$19395
$193$262125
$262$355240
$355$482205
$482$654215
$654$887170
$887$1,202113
$1,202$1,63169

By state

The median cash price in each state, against the national median of $420.

Alaska: 5 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 2 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: median $624 across 10 hospitalsNH$624Washington: median $485 across 39 hospitalsWA$485Idaho: 6 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 4 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: median $469 across 13 hospitalsND$469Minnesota: median $421 across 57 hospitalsMN$421Illinois: median $569 across 55 hospitalsIL$569Wisconsin: median $541 across 44 hospitalsWI$541Michigan: median $236 across 38 hospitalsMI$236New York: median $512 across 47 hospitalsNY$512Massachusetts: median $965 across 35 hospitalsMA$965Oregon: median $292 across 11 hospitalsOR$292Nevada: median $291 across 10 hospitalsNV$291Wyoming: 8 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: median $234 across 11 hospitalsSD$234Iowa: median $280 across 30 hospitalsIA$280Indiana: median $420 across 51 hospitalsIN$420Ohio: median $547 across 105 hospitalsOH$547Pennsylvania: median $627 across 66 hospitalsPA$627New Jersey: median $321 across 38 hospitalsNJ$321Connecticut: median $695 across 11 hospitalsCT$695Rhode Island: 2 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $483 across 46 hospitalsCA$483Utah: median $367 across 26 hospitalsUT$367Colorado: median $291 across 34 hospitalsCO$291Nebraska: 6 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $578 across 36 hospitalsMO$578Kentucky: median $199 across 25 hospitalsKY$199West Virginia: median $1,105 across 10 hospitalsWV$1,105Virginia: median $493 across 46 hospitalsVA$493Maryland: median $631 across 28 hospitalsMD$631Delaware: 6 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $400 across 20 hospitalsAZ$400New Mexico: 6 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $534 across 25 hospitalsKS$534Arkansas: median $190 across 17 hospitalsAR$190Tennessee: median $420 across 31 hospitalsTN$420North Carolina: median $308 across 63 hospitalsNC$308South Carolina: median $429 across 32 hospitalsSC$429Oklahoma: median $308 across 36 hospitalsOK$308Louisiana: median $402 across 28 hospitalsLA$402Mississippi: median $368 across 22 hospitalsMS$368Alabama: median $291 across 16 hospitalsAL$291Georgia: median $290 across 62 hospitalsGA$290Hawaii: median $439 across 11 hospitalsHI$439Texas: median $206 across 98 hospitalsTX$206Florida: median $223 across 71 hospitalsFL$223
Cash price by state, most expensive first. National median $420. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
West Virginia WV10$1,105+163%$590 – $1,175
Massachusetts MA35$965+130%$557 – $1,102
Connecticut CT11$695+65%$502 – $1,031
Maryland MD28$631+50%$125 – $889
Pennsylvania PA66$627+49%$197 – $1,214
New Hampshire NH10$624+49%$242 – $1,311
Missouri MO36$578+38%$421 – $763
Illinois IL55$569+36%$320 – $927
Ohio OH105$547+30%$239 – $1,073
Wisconsin WI44$541+29%$299 – $872
Kansas KS25$534+27%$266 – $1,492
New York NY47$512+22%$291 – $929
Virginia VA46$493+17%$144 – $1,147
Washington WA39$485+16%$321 – $807
California CA46$483+15%$169 – $666
North Dakota ND13$469+12%$188 – $825
Hawaii HI11$439+4%$439 – $1,467
South Carolina SC32$429+2%$391 – $578
Minnesota MN57$4210%$138 – $528
Indiana IN51$4200%$262 – $557
Tennessee TN31$4200%$186 – $470
Louisiana LA28$402−4%$232 – $804
Arizona AZ20$400−5%$267 – $1,001
Mississippi MS22$368−12%$184 – $471
Utah UT26$367−13%$367 – $431
New Jersey NJ38$321−24%$291 – $696
North Carolina NC63$308−27%$134 – $445
Oklahoma OK36$308−27%$259 – $709
Oregon OR11$292−30%$176 – $633
Colorado CO34$291−31%$115 – $772
Alabama AL16$291−31%$194 – $655
Nevada NV10$291−31%$54 – $816
Georgia GA62$290−31%$267 – $751
Iowa IA30$280−33%$280 – $881
Michigan MI38$236−44%$154 – $541
South Dakota SD11$234−44%$145 – $256
Florida FL71$223−47%$80 – $533
Texas TX98$206−51%$75 – $959
Kentucky KY25$199−53%$122 – $481
Arkansas AR17$190−55%$99 – $642
Wyoming WY8not enough hospitals filed a usable price
Delaware DE6not enough hospitals filed a usable price
Idaho ID6not enough hospitals filed a usable price
Nebraska NE6not enough hospitals filed a usable price
New Mexico NM6not enough hospitals filed a usable price
Alaska AK5not enough hospitals filed a usable price
Montana MT4not enough hospitals filed a usable price
Maine ME2not enough hospitals filed a usable price
Rhode Island RI2not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $420.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,193$399$185 – $862
Children’s26$274$74 – $483
Critical access273$502$272 – $825
Ownership
For-profit167$420$214 – $1,024
Government209$421$193 – $662
Non-profit1,116$420$195 – $854
System affiliation
Part of a system1,295$420$195 – $862
Independent205$435$210 – $806

Cash price vs list price

Median list price (chargemaster)$759
Median cash price$420
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,071 hospitals filed a usable inpatient cash price for this code. The median is $428 and the average of the middle 60% is $454; most fall between $198 and $878.

Cash price percentiles, inpatient, across 1,071 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$130$239$428$753$1,196

The most expensive tenth of hospitals charges at least 9.2× what the cheapest tenth charges ($130 vs $1,196).

Of the 1,207 hospitals that filed this code inpatient, 1,071 gave a usable cash price; 86 carried a plausibility flag, 1 filed a number their own filing marks as not a price, 0 gave an estimate, and 49 a list price only.

How complete is this

1,500 of the 3,956 hospitals with a price file in our corpus (38%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,660 hospitals that filed this code at all gave us
Usable cash price — counted1,500
Cash price carrying a plausibility flag — shown on the compare tool, excluded here103
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded55
Hospitals that filed this code1,660

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as GENE ANALYSIS (CYTOCHROME P450; FAMILY 2; SUBFAMILY C; POLYPEPTIDE 19) COMMON VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “CYP2C19 drug-processing gene test, common variants (CPT 81225) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81225-cyp2c19-drug-processing-gene-test-common-variants