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Procedure price report · Pathology

Cystic fibrosis gene test for missing or extra gene pieces

CPT 81222the billing code this page is about

A CFTR gene test that looks for deleted or duplicated segments of the gene, changes that standard variant panels and sequencing can miss.

Hospitals typically charge $672 cash for this outpatient procedure — the median across 909 hospitals that filed a usable cash price; the average of the middle 60% is $713. Most fall between $399 and $1,198 (20th–80th percentile).

Hospitals
909
States
50
Filings dated
Jun 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 909 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$197$425$672$1,062$1,550

The most expensive tenth of hospitals charges at least 7.9× what the cheapest tenth charges ($197 vs $1,550).

How the prices are spread

$142 – $187: 33 hospitals$142$187 – $248: 33 hospitals$248 – $327: 35 hospitals$248$327 – $432: 91 hospitals$432 – $571: 143 hospitals$432$571 – $754: 119 hospitals$754 – $997: 154 hospitals$754$997 – $1,317: 123 hospitals$1,317 – $1,740: 61 hospitals$1,317$1,740 – $2,299: 28 hospitals$1,740median $672price bands are equal on a log scale
Hospitals per price band (820 of 909 — the bands cover the 5th to 95th percentile)
FromToHospitals
$142$18733
$187$24833
$248$32735
$327$43291
$432$571143
$571$754119
$754$997154
$997$1,317123
$1,317$1,74061
$1,740$2,29928

By state

The median cash price in each state, against the national median of $672.

Alaska: 2 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: 8 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 3 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $428 across 23 hospitalsWA$428Idaho: 5 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 6 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 6 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $413 across 31 hospitalsMN$413Illinois: median $1,005 across 48 hospitalsIL$1,005Wisconsin: median $1,228 across 29 hospitalsWI$1,228Michigan: median $600 across 31 hospitalsMI$600New York: median $436 across 50 hospitalsNY$436Massachusetts: median $640 across 12 hospitalsMA$640Oregon: median $400 across 12 hospitalsOR$400Nevada: 7 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 3 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 4 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $418 across 28 hospitalsIA$418Indiana: median $688 across 17 hospitalsIN$688Ohio: median $918 across 56 hospitalsOH$918Pennsylvania: median $500 across 39 hospitalsPA$500New Jersey: median $479 across 35 hospitalsNJ$479Connecticut: 5 hospitals filed a usable price — fewer than 10, so no figureCTRhode Island: 1 hospital filed a usable price — fewer than 10, so no figureRICalifornia: median $997 across 37 hospitalsCA$997Utah: median $1,198 across 26 hospitalsUT$1,198Colorado: median $564 across 11 hospitalsCO$564Nebraska: 3 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $751 across 25 hospitalsMO$751Kentucky: 7 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: median $512 across 10 hospitalsWV$512Virginia: median $425 across 26 hospitalsVA$425Maryland: median $549 across 12 hospitalsMD$549Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: 7 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 4 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 4 hospitals filed a usable price — fewer than 10, so no figureKSArkansas: median $757 across 12 hospitalsAR$757Tennessee: median $158 across 16 hospitalsTN$158North Carolina: median $864 across 29 hospitalsNC$864South Carolina: median $1,435 across 17 hospitalsSC$1,435Oklahoma: median $779 across 27 hospitalsOK$779Louisiana: median $514 across 20 hospitalsLA$514Mississippi: median $352 across 13 hospitalsMS$352Alabama: 4 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $1,045 across 31 hospitalsGA$1,045Hawaii: 1 hospital filed a usable price — fewer than 10, so no figureHITexas: median $803 across 87 hospitalsTX$803Florida: median $142 across 15 hospitalsFL$142
Cash price by state, most expensive first. National median $672. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
South Carolina SC17$1,435+113%$208 – $1,435
Wisconsin WI29$1,228+83%$197 – $3,396
Utah UT26$1,198+78%$1,198 – $1,409
Georgia GA31$1,045+55%$780 – $1,100
Illinois IL48$1,005+50%$488 – $2,245
California CA37$997+48%$436 – $997
Ohio OH56$918+37%$575 – $989
North Carolina NC29$864+29%$482 – $1,094
Texas TX87$803+19%$466 – $1,300
Oklahoma OK27$779+16%$340 – $1,305
Arkansas AR12$757+13%$60 – $757
Missouri MO25$751+12%$685 – $823
Indiana IN17$688+2%$626 – $987
Massachusetts MA12$640−5%$429 – $1,047
Michigan MI31$600−11%$118 – $737
Colorado CO11$564−16%$436 – $1,114
Maryland MD12$549−18%$418 – $1,173
Louisiana LA20$514−23%$343 – $832
West Virginia WV10$512−24%$212 – $1,708
Pennsylvania PA39$500−26%$165 – $4,704
New Jersey NJ35$479−29%$435 – $950
New York NY50$436−35%$321 – $832
Washington WA23$428−36%$420 – $659
Virginia VA26$425−37%$330 – $2,107
Iowa IA28$418−38%$418 – $1,091
Minnesota MN31$413−39%$193 – $537
Oregon OR12$400−40%$379 – $1,296
Mississippi MS13$352−48%$308 – $645
Tennessee TN16$158−77%$155 – $352
Florida FL15$142−79%$63 – $441
Vermont VT8not enough hospitals filed a usable price
Arizona AZ7not enough hospitals filed a usable price
Kentucky KY7not enough hospitals filed a usable price
Nevada NV7not enough hospitals filed a usable price
Montana MT6not enough hospitals filed a usable price
North Dakota ND6not enough hospitals filed a usable price
Connecticut CT5not enough hospitals filed a usable price
Idaho ID5not enough hospitals filed a usable price
Alabama AL4not enough hospitals filed a usable price
Kansas KS4not enough hospitals filed a usable price
New Mexico NM4not enough hospitals filed a usable price
South Dakota SD4not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
Nebraska NE3not enough hospitals filed a usable price
New Hampshire NH3not enough hospitals filed a usable price
Wyoming WY3not enough hospitals filed a usable price
Alaska AK2not enough hospitals filed a usable price
Hawaii HI1not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price
Rhode Island RI1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $672.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care701$660$402 – $1,210
Children’s30$653$349 – $1,083
Critical access174$729$339 – $1,198
Ownership
For-profit69$803$435 – $1,740
Government116$579$364 – $1,067
Non-profit720$672$400 – $1,218
System affiliation
Part of a system822$685$402 – $1,198
Independent87$596$335 – $1,044

Cash price vs list price

Median list price (chargemaster)$1,273
Median cash price$672
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

663 hospitals filed a usable inpatient cash price for this code. The median is $636 and the average of the middle 60% is $693; most fall between $366 and $1,190.

Cash price percentiles, inpatient, across 663 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$197$418$636$1,047$1,435

The most expensive tenth of hospitals charges at least 7.3× what the cheapest tenth charges ($197 vs $1,435).

Of the 745 hospitals that filed this code inpatient, 663 gave a usable cash price; 52 carried a plausibility flag, 1 filed a number their own filing marks as not a price, 0 gave an estimate, and 29 a list price only.

How complete is this

909 of the 3,956 hospitals with a price file in our corpus (23%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,003 hospitals that filed this code at all gave us
Usable cash price — counted909
Cash price carrying a plausibility flag — shown on the compare tool, excluded here67
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded25
Hospitals that filed this code1,003

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as CFTR GENE DUP/DELET VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Cystic fibrosis gene test for missing or extra gene pieces (CPT 81222) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81222-cystic-fibrosis-gene-test-for-missing-or-extra-gene-pieces