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Procedure price report · Pathology

Cystic fibrosis gene test for variants known in the family

CPT 81221the billing code this page is about

A targeted CFTR gene test that checks only for the specific cystic fibrosis variant or variants already identified in a relative.

Hospitals typically charge $206 cash for this outpatient procedure — the median across 369 hospitals that filed a usable cash price; the average of the middle 60% is $231. Most fall between $117 and $440 (20th–80th percentile).

Hospitals
369
States
36
Filings dated
Sep 2025 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 369 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$97$128$206$392$666

The most expensive tenth of hospitals charges at least 6.9× what the cheapest tenth charges ($97 vs $666).

How the prices are spread

$89 – $114: 49 hospitals$89$114 – $146: 56 hospitals$146 – $188: 50 hospitals$146$188 – $241: 47 hospitals$241 – $310: 22 hospitals$241$310 – $398: 37 hospitals$398 – $511: 43 hospitals$398$511 – $656: 9 hospitals$656 – $842: 16 hospitals$656$842 – $1,081: 4 hospitals$842median $206price bands are equal on a log scale
Hospitals per price band (333 of 369 — the bands cover the 5th to 95th percentile)
FromToHospitals
$89$11449
$114$14656
$146$18850
$188$24147
$241$31022
$310$39837
$398$51143
$511$6569
$656$84216
$842$1,0814

By state

The median cash price in each state, against the national median of $206.

Alaska: no hospital in the corpus filed a usable priceAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: no hospital in the corpus filed a usable priceNHWashington: median $154 across 17 hospitalsWA$154Idaho: no hospital in the corpus filed a usable priceIDMontana: no hospital in the corpus filed a usable priceMTNorth Dakota: no hospital in the corpus filed a usable priceNDMinnesota: median $375 across 18 hospitalsMN$375Illinois: median $341 across 20 hospitalsIL$341Wisconsin: 8 hospitals filed a usable price — fewer than 10, so no figureWIMichigan: median $442 across 15 hospitalsMI$442New York: median $97 across 21 hospitalsNY$97Massachusetts: median $162 across 12 hospitalsMA$162Oregon: 4 hospitals filed a usable price — fewer than 10, so no figureORNevada: 4 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: no hospital in the corpus filed a usable priceSDIowa: median $128 across 13 hospitalsIA$128Indiana: median $221 across 23 hospitalsIN$221Ohio: median $395 across 36 hospitalsOH$395Pennsylvania: median $165 across 26 hospitalsPA$165New Jersey: median $107 across 22 hospitalsNJ$107Connecticut: no hospital in the corpus filed a usable priceCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $223 across 23 hospitalsCA$223Utah: 3 hospitals filed a usable price — fewer than 10, so no figureUTColorado: 3 hospitals filed a usable price — fewer than 10, so no figureCONebraska: no hospital in the corpus filed a usable priceNEMissouri: median $400 across 10 hospitalsMO$400Kentucky: 5 hospitals filed a usable price — fewer than 10, so no figureKYWest Virginia: 2 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $339 across 10 hospitalsVA$339Maryland: 1 hospital filed a usable price — fewer than 10, so no figureMDDelaware: 1 hospital filed a usable price — fewer than 10, so no figureDEArizona: 3 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: 2 hospitals filed a usable price — fewer than 10, so no figureNMKansas: 1 hospital filed a usable price — fewer than 10, so no figureKSArkansas: 3 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $158 across 11 hospitalsTN$158North Carolina: 4 hospitals filed a usable price — fewer than 10, so no figureNCSouth Carolina: no hospital in the corpus filed a usable priceSCOklahoma: median $171 across 16 hospitalsOK$171Louisiana: 1 hospital filed a usable price — fewer than 10, so no figureLAMississippi: 1 hospital filed a usable price — fewer than 10, so no figureMSAlabama: no hospital in the corpus filed a usable priceALGeorgia: 5 hospitals filed a usable price — fewer than 10, so no figureGAHawaii: no hospital in the corpus filed a usable priceHITexas: median $117 across 20 hospitalsTX$117Florida: 4 hospitals filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $206. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Michigan MI15$442+115%$134 – $442
Missouri MO10$400+95%$378 – $412
Ohio OH36$395+92%$206 – $827
Minnesota MN18$375+82%$155 – $440
Illinois IL20$341+66%$140 – $1,327
Virginia VA10$339+65%$283 – $634
California CA23$223+9%$223 – $223
Indiana IN23$221+7%$140 – $410
Oklahoma OK16$171−17%$171 – $344
Pennsylvania PA26$165−20%$141 – $340
Massachusetts MA12$162−21%$90 – $807
Tennessee TN11$158−23%$155 – $1,360
Washington WA17$154−25%$64 – $308
Iowa IA13$128−38%$128 – $128
Texas TX20$117−43%$117 – $117
New Jersey NJ22$107−48%$97 – $107
New York NY21$97−53%$97 – $171
Wisconsin WI8not enough hospitals filed a usable price
Georgia GA5not enough hospitals filed a usable price
Kentucky KY5not enough hospitals filed a usable price
Florida FL4not enough hospitals filed a usable price
North Carolina NC4not enough hospitals filed a usable price
Nevada NV4not enough hospitals filed a usable price
Oregon OR4not enough hospitals filed a usable price
Arkansas AR3not enough hospitals filed a usable price
Arizona AZ3not enough hospitals filed a usable price
Colorado CO3not enough hospitals filed a usable price
Utah UT3not enough hospitals filed a usable price
New Mexico NM2not enough hospitals filed a usable price
West Virginia WV2not enough hospitals filed a usable price
Delaware DE1not enough hospitals filed a usable price
Kansas KS1not enough hospitals filed a usable price
Louisiana LA1not enough hospitals filed a usable price
Maryland MD1not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price
Mississippi MS1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $206.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care308$183$112 – $400
Children’s17fewer than 20 hospitals
Critical access41$272$154 – $446
Ownership
For-profit20$146$88 – $301
Government29$221$97 – $433
Non-profit317$206$117 – $440
System affiliation
Part of a system342$206$117 – $440
Independent27$195$123 – $357

Cash price vs list price

Median list price (chargemaster)$494
Median cash price$206
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

292 hospitals filed a usable inpatient cash price for this code. The median is $223 and the average of the middle 60% is $270; most fall between $135 and $442.

Cash price percentiles, inpatient, across 292 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$117$154$223$433$820

The most expensive tenth of hospitals charges at least 7.0× what the cheapest tenth charges ($117 vs $820).

Of the 308 hospitals that filed this code inpatient, 292 gave a usable cash price; 4 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 12 a list price only.

How complete is this

369 of the 3,956 hospitals with a price file in our corpus (9%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 401 hospitals that filed this code at all gave us
Usable cash price — counted369
Cash price carrying a plausibility flag — shown on the compare tool, excluded here11
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded20
Hospitals that filed this code401

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Pathology family.

Hospitals file this code under descriptions such as CFTR GENE KNOWN FAM VARIANTS.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Cystic fibrosis gene test for variants known in the family (CPT 81221) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-81221-cystic-fibrosis-gene-test-for-variants-known-in-the-family