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Procedure price report · Laboratory - Chemistry and Hematology

Special stain for enzyme activity in tissue

CPT 88319the billing code this page is about

A chemical stain that detects enzyme or similar chemical activity in tissue or cells, with interpretation. Billed once for each stain performed on each specimen.

Hospitals typically charge $356 cash for this outpatient procedure — the median across 1,919 hospitals that filed a usable cash price; the average of the middle 60% is $386. Most fall between $134 and $823 (20th–80th percentile).

Hospitals
1,919
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,919 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$77$157$356$690$1,398

The most expensive tenth of hospitals charges at least 18× what the cheapest tenth charges ($77 vs $1,398).

How the prices are spread

$49 – $71: 79 hospitals$49$71 – $103: 103 hospitals$103 – $151: 184 hospitals$103$151 – $219: 247 hospitals$219 – $320: 211 hospitals$219$320 – $466: 218 hospitals$466 – $679: 290 hospitals$466$679 – $989: 215 hospitals$989 – $1,441: 90 hospitals$989$1,441 – $2,099: 95 hospitals$1,441median $356price bands are equal on a log scale
Hospitals per price band (1,732 of 1,919 — the bands cover the 5th to 95th percentile)
FromToHospitals
$49$7179
$71$103103
$103$151184
$151$219247
$219$320211
$320$466218
$466$679290
$679$989215
$989$1,44190
$1,441$2,09995

Against Medicare

Medicare pays (OPPS 2026, national rate)$823
Median cash price$356
Cash as a multiple of Medicare0.43×

The Medicare figure is the national unadjusted OPPS rate for this code — what Medicare itself pays a hospital before local wage adjustment. It is a benchmark, not a price anyone is charged.

By state

The median cash price in each state, against the national median of $356.

Alaska: 8 hospitals filed a usable price — fewer than 10, so no figureAKMaine: median $230 across 18 hospitalsME$230Vermont: 5 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 8 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $365 across 39 hospitalsWA$365Idaho: median $160 across 12 hospitalsID$160Montana: median $226 across 12 hospitalsMT$226North Dakota: median $416 across 12 hospitalsND$416Minnesota: median $163 across 54 hospitalsMN$163Illinois: median $467 across 77 hospitalsIL$467Wisconsin: median $265 across 86 hospitalsWI$265Michigan: median $206 across 68 hospitalsMI$206New York: median $836 across 63 hospitalsNY$836Massachusetts: median $533 across 35 hospitalsMA$533Oregon: median $260 across 29 hospitalsOR$260Nevada: median $893 across 10 hospitalsNV$893Wyoming: 6 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $581 across 32 hospitalsIA$581Indiana: median $487 across 66 hospitalsIN$487Ohio: median $510 across 102 hospitalsOH$510Pennsylvania: median $627 across 75 hospitalsPA$627New Jersey: median $893 across 46 hospitalsNJ$893Connecticut: median $316 across 14 hospitalsCT$316Rhode Island: 5 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $504 across 93 hospitalsCA$504Utah: median $586 across 32 hospitalsUT$586Colorado: median $717 across 36 hospitalsCO$717Nebraska: median $419 across 19 hospitalsNE$419Missouri: median $387 across 50 hospitalsMO$387Kentucky: median $310 across 31 hospitalsKY$310West Virginia: median $111 across 21 hospitalsWV$111Virginia: median $262 across 32 hospitalsVA$262Maryland: median $132 across 37 hospitalsMD$132Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $653 across 24 hospitalsAZ$653New Mexico: median $369 across 13 hospitalsNM$369Kansas: median $479 across 28 hospitalsKS$479Arkansas: median $247 across 18 hospitalsAR$247Tennessee: median $208 across 34 hospitalsTN$208North Carolina: median $232 across 53 hospitalsNC$232South Carolina: median $437 across 42 hospitalsSC$437Oklahoma: median $252 across 42 hospitalsOK$252Louisiana: median $244 across 37 hospitalsLA$244Mississippi: median $172 across 33 hospitalsMS$172Alabama: median $797 across 26 hospitalsAL$797Georgia: median $215 across 73 hospitalsGA$215Hawaii: median $705 across 15 hospitalsHI$705Texas: median $215 across 142 hospitalsTX$215Florida: median $164 across 100 hospitalsFL$164
Cash price by state, most expensive first. National median $356. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Nevada NV10$893+151%$91 – $1,827
New Jersey NJ46$893+151%$221 – $1,042
New York NY63$836+135%$136 – $1,744
Alabama AL26$797+124%$313 – $938
Colorado CO36$717+102%$558 – $1,679
Hawaii HI15$705+98%$319 – $1,759
Arizona AZ24$653+84%$167 – $857
Pennsylvania PA75$627+76%$337 – $1,162
Utah UT32$586+65%$325 – $690
Iowa IA32$581+63%$187 – $787
Massachusetts MA35$533+50%$224 – $1,226
Ohio OH102$510+43%$202 – $679
California CA93$504+42%$138 – $1,758
Indiana IN66$487+37%$233 – $821
Kansas KS28$479+35%$118 – $663
Illinois IL77$467+31%$186 – $787
South Carolina SC42$437+23%$227 – $532
Nebraska NE19$419+18%$164 – $653
North Dakota ND12$416+17%$188 – $1,214
Missouri MO50$387+9%$184 – $605
New Mexico NM13$369+4%$74 – $814
Washington WA39$365+3%$150 – $813
Connecticut CT14$316−11%$238 – $1,142
Kentucky KY31$310−13%$173 – $843
Wisconsin WI86$265−25%$206 – $486
Virginia VA32$262−26%$210 – $427
Oregon OR29$260−27%$96 – $592
Oklahoma OK42$252−29%$146 – $596
Arkansas AR18$247−31%$173 – $962
Louisiana LA37$244−31%$81 – $522
North Carolina NC53$232−35%$112 – $531
Maine ME18$230−35%$169 – $656
Montana MT12$226−36%$134 – $345
Texas TX142$215−39%$132 – $531
Georgia GA73$215−39%$91 – $1,038
Tennessee TN34$208−42%$82 – $277
Michigan MI68$206−42%$45 – $849
Mississippi MS33$172−52%$71 – $298
Florida FL100$164−54%$69 – $654
Minnesota MN54$163−54%$50 – $375
Idaho ID12$160−55%$110 – $586
Maryland MD37$132−63%$104 – $163
West Virginia WV21$111−69%$45 – $427
Alaska AK8not enough hospitals filed a usable price
New Hampshire NH8not enough hospitals filed a usable price
Wyoming WY6not enough hospitals filed a usable price
Rhode Island RI5not enough hospitals filed a usable price
Vermont VT5not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
South Dakota SD3not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $356.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,558$380$133 – $893
Children’s56$286$144 – $459
Critical access297$251$135 – $586
Ownership
For-profit257$400$145 – $830
Government242$310$102 – $910
Non-profit1,412$356$139 – $813
System affiliation
Part of a system1,669$356$137 – $814
Independent250$359$112 – $968

Cash price vs list price

Median list price (chargemaster)$588
Median cash price$356
Cash as a share of list, median hospital61%

At the typical hospital, asking for the cash price cuts the list price by about 39%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,403 hospitals filed a usable inpatient cash price for this code. The median is $377 and the average of the middle 60% is $395; most fall between $136 and $814.

Cash price percentiles, inpatient, across 1,403 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$82$163$377$690$1,682

The most expensive tenth of hospitals charges at least 21× what the cheapest tenth charges ($82 vs $1,682).

Of the 1,560 hospitals that filed this code inpatient, 1,403 gave a usable cash price; 109 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 48 a list price only.

How complete is this

1,919 of the 3,956 hospitals with a price file in our corpus (49%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 2,107 hospitals that filed this code at all gave us
Usable cash price — counted1,919
Cash price carrying a plausibility flag — shown on the compare tool, excluded here136
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded51
Hospitals that filed this code2,107

Sections not shown for this setting

  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Laboratory - Chemistry and Hematology family.

Hospitals file this code under descriptions such as Special Stain I&R Group III Enzyme Consituents|PROFESSIONAL COMPONENT.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Special stain for enzyme activity in tissue (CPT 88319) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-88319-special-stain-for-enzyme-activity-in-tissue