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Procedure price report · Other Laboratory

HE4 protein tumor marker blood test

CPT 86305the billing code this page is about

Blood test measuring human epididymis protein 4, a marker used in the evaluation of ovarian masses and cancer.

Hospitals typically charge $137 cash for this outpatient procedure — the median across 1,644 hospitals that filed a usable cash price; the average of the middle 60% is $148. Most fall between $56 and $272 (20th–80th percentile).

Hospitals
1,644
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,644 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$34$71$137$245$398

The most expensive tenth of hospitals charges at least 12× what the cheapest tenth charges ($34 vs $398).

How the prices are spread

$23 – $31: 68 hospitals$23$31 – $43: 92 hospitals$43 – $60: 102 hospitals$43$60 – $82: 134 hospitals$82 – $113: 245 hospitals$82$113 – $155: 161 hospitals$155 – $214: 256 hospitals$155$214 – $294: 212 hospitals$294 – $404: 134 hospitals$294$404 – $556: 76 hospitals$404median $137price bands are equal on a log scale
Hospitals per price band (1,480 of 1,644 — the bands cover the 5th to 95th percentile)
FromToHospitals
$23$3168
$31$4392
$43$60102
$60$82134
$82$113245
$113$155161
$155$214256
$214$294212
$294$404134
$404$55676

By state

The median cash price in each state, against the national median of $137.

Alaska: median $197 across 12 hospitalsAK$197Maine: 9 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 3 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: 7 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $126 across 46 hospitalsWA$126Idaho: 8 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 5 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: median $39 across 13 hospitalsND$39Minnesota: median $98 across 39 hospitalsMN$98Illinois: median $203 across 93 hospitalsIL$203Wisconsin: median $188 across 56 hospitalsWI$188Michigan: median $106 across 52 hospitalsMI$106New York: median $85 across 87 hospitalsNY$85Massachusetts: median $84 across 33 hospitalsMA$84Oregon: median $206 across 22 hospitalsOR$206Nevada: median $63 across 10 hospitalsNV$63Wyoming: 7 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $78 across 32 hospitalsIA$78Indiana: median $161 across 41 hospitalsIN$161Ohio: median $125 across 97 hospitalsOH$125Pennsylvania: median $166 across 72 hospitalsPA$166New Jersey: median $23 across 51 hospitalsNJ$23Connecticut: median $92 across 12 hospitalsCT$92Rhode Island: median $77 across 10 hospitalsRI$77California: median $120 across 77 hospitalsCA$120Utah: 7 hospitals filed a usable price — fewer than 10, so no figureUTColorado: median $162 across 29 hospitalsCO$162Nebraska: 7 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $171 across 31 hospitalsMO$171Kentucky: median $244 across 23 hospitalsKY$244West Virginia: median $256 across 19 hospitalsWV$256Virginia: median $89 across 40 hospitalsVA$89Maryland: median $388 across 24 hospitalsMD$388Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $152 across 33 hospitalsAZ$152New Mexico: 9 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $209 across 14 hospitalsKS$209Arkansas: median $157 across 13 hospitalsAR$157Tennessee: median $105 across 32 hospitalsTN$105North Carolina: median $128 across 73 hospitalsNC$128South Carolina: median $224 across 33 hospitalsSC$224Oklahoma: median $99 across 33 hospitalsOK$99Louisiana: median $46 across 34 hospitalsLA$46Mississippi: median $104 across 15 hospitalsMS$104Alabama: median $241 across 16 hospitalsAL$241Georgia: median $239 across 65 hospitalsGA$239Hawaii: median $248 across 11 hospitalsHI$248Texas: median $109 across 92 hospitalsTX$109Florida: median $180 across 91 hospitalsFL$180
Cash price by state, most expensive first. National median $137. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Maryland MD24$388+183%$289 – $423
West Virginia WV19$256+87%$115 – $256
Hawaii HI11$248+81%$143 – $250
Kentucky KY23$244+78%$105 – $563
Alabama AL16$241+76%$73 – $330
Georgia GA65$239+74%$120 – $324
South Carolina SC33$224+63%$110 – $479
Kansas KS14$209+52%$81 – $628
Oregon OR22$206+50%$180 – $293
Illinois IL93$203+48%$87 – $429
Alaska AK12$197+44%$147 – $415
Wisconsin WI56$188+37%$88 – $255
Florida FL91$180+31%$69 – $299
Missouri MO31$171+25%$88 – $208
Pennsylvania PA72$166+21%$31 – $409
Colorado CO29$162+18%$98 – $333
Indiana IN41$161+17%$34 – $204
Arkansas AR13$157+14%$90 – $268
Arizona AZ33$152+11%$34 – $187
North Carolina NC73$128−6%$47 – $214
Washington WA46$126−8%$64 – $285
Ohio OH97$125−9%$73 – $205
California CA77$120−13%$97 – $215
Texas TX92$109−21%$105 – $320
Michigan MI52$106−23%$42 – $181
Tennessee TN32$105−24%$42 – $183
Mississippi MS15$104−24%$23 – $157
Oklahoma OK33$99−28%$37 – $257
Minnesota MN39$98−29%$51 – $359
Connecticut CT12$92−33%$80 – $231
Virginia VA40$89−36%$57 – $164
New York NY87$85−38%$25 – $245
Massachusetts MA33$84−39%$46 – $215
Iowa IA32$78−43%$49 – $183
Rhode Island RI10$77−44%$74 – $130
Nevada NV10$63−54%$44 – $107
Louisiana LA34$46−66%$21 – $260
North Dakota ND13$39−72%$35 – $138
New Jersey NJ51$23−83%$21 – $53
Maine ME9not enough hospitals filed a usable price
New Mexico NM9not enough hospitals filed a usable price
Idaho ID8not enough hospitals filed a usable price
Nebraska NE7not enough hospitals filed a usable price
New Hampshire NH7not enough hospitals filed a usable price
Utah UT7not enough hospitals filed a usable price
Wyoming WY7not enough hospitals filed a usable price
Montana MT5not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
South Dakota SD3not enough hospitals filed a usable price
Vermont VT3not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $137.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,323$132$51 – $265
Children’s9fewer than 20 hospitals
Critical access303$166$68 – $315
Ownership
For-profit191$152$74 – $309
Government245$152$54 – $271
Non-profit1,199$131$52 – $268
System affiliation
Part of a system1,393$135$54 – $267
Independent251$150$62 – $298

Cash price vs list price

Median list price (chargemaster)$245
Median cash price$137
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,199 hospitals filed a usable inpatient cash price for this code. The median is $147 and the average of the middle 60% is $155; most fall between $66 and $273.

Cash price percentiles, inpatient, across 1,199 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$39$80$147$248$396

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($39 vs $396).

Of the 1,330 hospitals that filed this code inpatient, 1,199 gave a usable cash price; 79 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 52 a list price only.

How complete is this

1,644 of the 3,956 hospitals with a price file in our corpus (42%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,811 hospitals that filed this code at all gave us
Usable cash price — counted1,644
Cash price carrying a plausibility flag — shown on the compare tool, excluded here105
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded60
Hospitals that filed this code1,811

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 24, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Other Laboratory family.

Hospitals file this code under descriptions such as HUMAN EPIDIDYMIS PROTEIN 4.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “HE4 protein tumor marker blood test (CPT 86305) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-86305-he4-protein-tumor-marker-blood-test