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Procedure price report · Laboratory - Chemistry and Hematology

Blood test for free protein S

CPT 85306the billing code this page is about

A blood test measuring the unbound, active portion of protein S, a natural clot-limiting protein. Billed once per test.

Hospitals typically charge $96 cash for this outpatient procedure — the median across 3,196 hospitals that filed a usable cash price; the average of the middle 60% is $100. Most fall between $33 and $190 (20th–80th percentile).

Hospitals
3,196
States
50
Filings dated
Dec 2022 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 3,196 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$19$41$96$166$266

The most expensive tenth of hospitals charges at least 14× what the cheapest tenth charges ($19 vs $266).

How the prices are spread

$15 – $21: 195 hospitals$15$21 – $28: 182 hospitals$28 – $39: 237 hospitals$28$39 – $54: 246 hospitals$54 – $74: 283 hospitals$54$74 – $101: 372 hospitals$101 – $139: 466 hospitals$101$139 – $191: 429 hospitals$191 – $263: 296 hospitals$191$263 – $361: 172 hospitals$263median $96price bands are equal on a log scale
Hospitals per price band (2,878 of 3,196 — the bands cover the 5th to 95th percentile)
FromToHospitals
$15$21195
$21$28182
$28$39237
$39$54246
$54$74283
$74$101372
$101$139466
$139$191429
$191$263296
$263$361172

By state

The median cash price in each state, against the national median of $96.

Alaska: median $171 across 18 hospitalsAK$171Maine: median $80 across 28 hospitalsME$80Vermont: median $208 across 13 hospitalsVT$208New Hampshire: median $56 across 25 hospitalsNH$56Washington: median $117 across 74 hospitalsWA$117Idaho: median $86 across 22 hospitalsID$86Montana: median $113 across 27 hospitalsMT$113North Dakota: median $77 across 29 hospitalsND$77Minnesota: median $114 across 102 hospitalsMN$114Illinois: median $136 across 141 hospitalsIL$136Wisconsin: median $152 across 104 hospitalsWI$152Michigan: median $34 across 98 hospitalsMI$34New York: median $61 across 106 hospitalsNY$61Massachusetts: median $107 across 51 hospitalsMA$107Oregon: median $78 across 46 hospitalsOR$78Nevada: median $77 across 19 hospitalsNV$77Wyoming: median $138 across 16 hospitalsWY$138South Dakota: median $220 across 27 hospitalsSD$220Iowa: median $104 across 80 hospitalsIA$104Indiana: median $81 across 97 hospitalsIN$81Ohio: median $90 across 140 hospitalsOH$90Pennsylvania: median $92 across 121 hospitalsPA$92New Jersey: median $18 across 55 hospitalsNJ$18Connecticut: median $82 across 21 hospitalsCT$82Rhode Island: median $78 across 10 hospitalsRI$78California: median $35 across 145 hospitalsCA$35Utah: median $138 across 40 hospitalsUT$138Colorado: median $107 across 69 hospitalsCO$107Nebraska: median $196 across 73 hospitalsNE$196Missouri: median $122 across 73 hospitalsMO$122Kentucky: median $134 across 68 hospitalsKY$134West Virginia: median $59 across 41 hospitalsWV$59Virginia: median $97 across 73 hospitalsVA$97Maryland: median $132 across 39 hospitalsMD$132Delaware: 6 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $123 across 39 hospitalsAZ$123New Mexico: median $126 across 26 hospitalsNM$126Kansas: median $131 across 81 hospitalsKS$131Arkansas: median $50 across 38 hospitalsAR$50Tennessee: median $75 across 80 hospitalsTN$75North Carolina: median $91 across 87 hospitalsNC$91South Carolina: median $149 across 51 hospitalsSC$149Oklahoma: median $93 across 67 hospitalsOK$93Louisiana: median $61 across 49 hospitalsLA$61Mississippi: median $48 across 54 hospitalsMS$48Alabama: median $58 across 41 hospitalsAL$58Georgia: median $139 across 98 hospitalsGA$139Hawaii: median $96 across 17 hospitalsHI$96Texas: median $122 across 232 hospitalsTX$122Florida: median $25 across 139 hospitalsFL$25
Cash price by state, most expensive first. National median $96. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
South Dakota SD27$220+130%$118 – $347
Vermont VT13$208+118%$80 – $255
Nebraska NE73$196+105%$58 – $290
Alaska AK18$171+79%$48 – $263
Wisconsin WI104$152+59%$73 – $190
South Carolina SC51$149+56%$48 – $222
Georgia GA98$139+45%$51 – $233
Utah UT40$138+44%$112 – $162
Wyoming WY16$138+44%$41 – $173
Illinois IL141$136+42%$70 – $291
Kentucky KY68$134+40%$44 – $209
Maryland MD39$132+38%$104 – $163
Kansas KS81$131+37%$76 – $228
New Mexico NM26$126+32%$64 – $266
Arizona AZ39$123+29%$30 – $227
Missouri MO73$122+28%$85 – $193
Texas TX232$122+27%$41 – $293
Washington WA74$117+22%$68 – $201
Minnesota MN102$114+19%$60 – $197
Montana MT27$113+18%$43 – $180
Massachusetts MA51$107+12%$48 – $230
Colorado CO69$107+12%$43 – $234
Iowa IA80$104+9%$33 – $158
Virginia VA73$97+2%$26 – $172
Hawaii HI17$960%$77 – $195
Oklahoma OK67$93−3%$47 – $163
Pennsylvania PA121$92−4%$23 – $180
North Carolina NC87$91−5%$26 – $190
Ohio OH140$90−6%$42 – $137
Idaho ID22$86−10%$68 – $115
Connecticut CT21$82−14%$39 – $128
Indiana IN97$81−15%$40 – $196
Maine ME28$80−16%$39 – $136
Oregon OR46$78−18%$37 – $160
Rhode Island RI10$78−18%$51 – $114
North Dakota ND29$77−19%$27 – $115
Nevada NV19$77−19%$17 – $256
Tennessee TN80$75−22%$25 – $140
New York NY106$61−36%$23 – $184
Louisiana LA49$61−36%$25 – $150
West Virginia WV41$59−39%$15 – $114
Alabama AL41$58−40%$33 – $221
New Hampshire NH25$56−41%$39 – $215
Arkansas AR38$50−48%$23 – $114
Mississippi MS54$48−50%$18 – $107
California CA145$35−63%$14 – $124
Michigan MI98$34−64%$18 – $75
Florida FL139$25−74%$15 – $82
New Jersey NJ55$18−82%$17 – $52
Delaware DE6not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $96.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care2,240$87$28 – $180
Children’s59$114$48 – $169
Critical access887$114$51 – $210
Ownership
For-profit445$105$29 – $268
Government585$109$39 – $211
Non-profit2,156$91$33 – $174
System affiliation
Part of a system2,609$95$31 – $190
Independent587$99$41 – $184

Cash price vs list price

Median list price (chargemaster)$157
Median cash price$96
Cash as a share of list, median hospital65%

At the typical hospital, asking for the cash price cuts the list price by about 35%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

2,166 hospitals filed a usable inpatient cash price for this code. The median is $95 and the average of the middle 60% is $98; most fall between $36 and $181.

Cash price percentiles, inpatient, across 2,166 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$23$42$95$162$241

The most expensive tenth of hospitals charges at least 10× what the cheapest tenth charges ($23 vs $241).

Of the 2,382 hospitals that filed this code inpatient, 2,166 gave a usable cash price; 109 carried a plausibility flag, 1 filed a number their own filing marks as not a price, 0 gave an estimate, and 106 a list price only.

How complete is this

3,196 of the 3,956 hospitals with a price file in our corpus (81%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 3,476 hospitals that filed this code at all gave us
Usable cash price — counted3,196
Cash price carrying a plausibility flag — shown on the compare tool, excluded here152
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded1
An estimate rather than a filed cash price — excluded1
A list price only, no cash figure — excluded126
Hospitals that filed this code3,476

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between July 20, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Laboratory - Chemistry and Hematology family.

Hospitals file this code under descriptions such as HC Protein S Screen.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Blood test for free protein S (CPT 85306) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-85306-blood-test-for-free-protein-s