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Procedure price report · Laboratory - Chemistry and Hematology

Pyruvate kinase enzyme test

CPT 84220the billing code this page is about

Measures the activity of the enzyme pyruvate kinase in red blood cells.

Hospitals typically charge $68 cash for this outpatient procedure — the median across 1,468 hospitals that filed a usable cash price; the average of the middle 60% is $75. Most fall between $29 and $147 (20th–80th percentile).

Hospitals
1,468
States
50
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,468 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$15$36$68$124$202

The most expensive tenth of hospitals charges at least 13× what the cheapest tenth charges ($15 vs $202).

How the prices are spread

$10 – $15: 79 hospitals$10$15 – $21: 66 hospitals$21 – $30: 91 hospitals$21$30 – $43: 171 hospitals$43 – $61: 178 hospitals$43$61 – $87: 229 hospitals$87 – $124: 222 hospitals$87$124 – $177: 171 hospitals$177 – $253: 87 hospitals$177$253 – $360: 35 hospitals$253median $68price bands are equal on a log scale
Hospitals per price band (1,329 of 1,468 — the bands cover the 5th to 95th percentile)
FromToHospitals
$10$1579
$15$2166
$21$3091
$30$43171
$43$61178
$61$87229
$87$124222
$124$177171
$177$25387
$253$36035

By state

The median cash price in each state, against the national median of $68.

Alaska: 4 hospitals filed a usable price — fewer than 10, so no figureAKMaine: 8 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 1 hospital filed a usable price — fewer than 10, so no figureVTNew Hampshire: 5 hospitals filed a usable price — fewer than 10, so no figureNHWashington: median $41 across 21 hospitalsWA$41Idaho: 6 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 4 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 7 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: median $67 across 35 hospitalsMN$67Illinois: median $89 across 77 hospitalsIL$89Wisconsin: median $68 across 51 hospitalsWI$68Michigan: median $41 across 46 hospitalsMI$41New York: median $28 across 61 hospitalsNY$28Massachusetts: median $87 across 27 hospitalsMA$87Oregon: median $39 across 17 hospitalsOR$39Nevada: 5 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: 4 hospitals filed a usable price — fewer than 10, so no figureWYSouth Dakota: 2 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $50 across 27 hospitalsIA$50Indiana: median $57 across 43 hospitalsIN$57Ohio: median $97 across 93 hospitalsOH$97Pennsylvania: median $34 across 62 hospitalsPA$34New Jersey: median $10 across 41 hospitalsNJ$10Connecticut: median $57 across 14 hospitalsCT$57Rhode Island: 6 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $116 across 72 hospitalsCA$116Utah: median $375 across 27 hospitalsUT$375Colorado: median $69 across 34 hospitalsCO$69Nebraska: 8 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: median $56 across 26 hospitalsMO$56Kentucky: median $111 across 24 hospitalsKY$111West Virginia: 9 hospitals filed a usable price — fewer than 10, so no figureWVVirginia: median $78 across 34 hospitalsVA$78Maryland: median $44 across 19 hospitalsMD$44Delaware: 5 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $23 across 24 hospitalsAZ$23New Mexico: 7 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $128 across 27 hospitalsKS$128Arkansas: median $49 across 13 hospitalsAR$49Tennessee: median $43 across 28 hospitalsTN$43North Carolina: median $92 across 65 hospitalsNC$92South Carolina: median $150 across 27 hospitalsSC$150Oklahoma: median $46 across 30 hospitalsOK$46Louisiana: median $28 across 26 hospitalsLA$28Mississippi: median $63 across 22 hospitalsMS$63Alabama: median $97 across 14 hospitalsAL$97Georgia: median $61 across 41 hospitalsGA$61Hawaii: median $67 across 12 hospitalsHI$67Texas: median $53 across 128 hospitalsTX$53Florida: median $73 across 79 hospitalsFL$73
Cash price by state, most expensive first. National median $68. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Utah UT27$375+450%$349 – $441
South Carolina SC27$150+120%$60 – $157
Kansas KS27$128+87%$68 – $306
California CA72$116+71%$41 – $147
Kentucky KY24$111+62%$35 – $156
Alabama AL14$97+43%$22 – $362
Ohio OH93$97+42%$41 – $128
North Carolina NC65$92+36%$42 – $170
Illinois IL77$89+30%$40 – $147
Massachusetts MA27$87+28%$23 – $160
Virginia VA34$78+14%$42 – $111
Florida FL79$73+8%$38 – $146
Colorado CO34$69+2%$51 – $154
Wisconsin WI51$68−1%$48 – $182
Hawaii HI12$67−2%$57 – $132
Minnesota MN35$67−2%$53 – $195
Mississippi MS22$63−7%$29 – $85
Georgia GA41$61−10%$24 – $151
Indiana IN43$57−16%$17 – $95
Connecticut CT14$57−16%$32 – $123
Missouri MO26$56−17%$43 – $144
Texas TX128$53−23%$39 – $117
Iowa IA27$50−27%$34 – $103
Arkansas AR13$49−29%$15 – $64
Oklahoma OK30$46−32%$28 – $155
Maryland MD19$44−35%$31 – $57
Tennessee TN28$43−37%$17 – $122
Michigan MI46$41−39%$15 – $65
Washington WA21$41−41%$19 – $46
Oregon OR17$39−43%$8 – $88
Pennsylvania PA62$34−51%$11 – $111
New York NY61$28−59%$9 – $80
Louisiana LA26$28−59%$15 – $99
Arizona AZ24$23−66%$14 – $163
New Jersey NJ41$10−85%$9 – $116
West Virginia WV9not enough hospitals filed a usable price
Maine ME8not enough hospitals filed a usable price
Nebraska NE8not enough hospitals filed a usable price
North Dakota ND7not enough hospitals filed a usable price
New Mexico NM7not enough hospitals filed a usable price
Idaho ID6not enough hospitals filed a usable price
Rhode Island RI6not enough hospitals filed a usable price
Delaware DE5not enough hospitals filed a usable price
New Hampshire NH5not enough hospitals filed a usable price
Nevada NV5not enough hospitals filed a usable price
Alaska AK4not enough hospitals filed a usable price
Montana MT4not enough hospitals filed a usable price
Wyoming WY4not enough hospitals filed a usable price
South Dakota SD2not enough hospitals filed a usable price
Vermont VT1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $68.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,229$68$28 – $140
Children’s43$97$41 – $247
Critical access189$74$33 – $193
Ownership
For-profit188$69$30 – $210
Government167$79$34 – $156
Non-profit1,106$67$28 – $137
System affiliation
Part of a system1,275$68$29 – $145
Independent193$80$28 – $170

Cash price vs list price

Median list price (chargemaster)$132
Median cash price$68
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,061 hospitals filed a usable inpatient cash price for this code. The median is $68 and the average of the middle 60% is $76; most fall between $35 and $145.

Cash price percentiles, inpatient, across 1,061 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$23$41$68$123$194

The most expensive tenth of hospitals charges at least 8.6× what the cheapest tenth charges ($23 vs $194).

Of the 1,168 hospitals that filed this code inpatient, 1,061 gave a usable cash price; 68 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 39 a list price only.

How complete is this

1,468 of the 3,956 hospitals with a price file in our corpus (37%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,602 hospitals that filed this code at all gave us
Usable cash price — counted1,468
Cash price carrying a plausibility flag — shown on the compare tool, excluded here84
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded2
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded48
Hospitals that filed this code1,602

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Laboratory - Chemistry and Hematology family.

Hospitals file this code under descriptions such as HC Pyruvate Kinase.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Pyruvate kinase enzyme test (CPT 84220) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-84220-pyruvate-kinase-enzyme-test