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Procedure price report · Laboratory - Chemistry and Hematology

Biotinidase enzyme blood test

CPT 82261the billing code this page is about

A laboratory test that measures the activity of the enzyme biotinidase in a specimen; billed once per specimen tested.

Hospitals typically charge $49 cash for this outpatient procedure — the median across 1,834 hospitals that filed a usable cash price; the average of the middle 60% is $56. Most fall between $23 and $105 (20th–80th percentile).

Hospitals
1,834
States
50
Filings dated
Nov 2023 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 25, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 1,834 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$16$26$49$92$184

The most expensive tenth of hospitals charges at least 11× what the cheapest tenth charges ($16 vs $184).

How the prices are spread

$12 – $17: 94 hospitals$12$17 – $23: 200 hospitals$23 – $32: 187 hospitals$23$32 – $45: 236 hospitals$45 – $63: 265 hospitals$45$63 – $88: 223 hospitals$88 – $122: 211 hospitals$88$122 – $171: 114 hospitals$171 – $238: 86 hospitals$171$238 – $332: 41 hospitals$238median $49price bands are equal on a log scale
Hospitals per price band (1,657 of 1,834 — the bands cover the 5th to 95th percentile)
FromToHospitals
$12$1794
$17$23200
$23$32187
$32$45236
$45$63265
$63$88223
$88$122211
$122$171114
$171$23886
$238$33241

By state

The median cash price in each state, against the national median of $49.

Alaska: median $108 across 10 hospitalsAK$108Maine: 3 hospitals filed a usable price — fewer than 10, so no figureMEVermont: 2 hospitals filed a usable price — fewer than 10, so no figureVTNew Hampshire: median $25 across 10 hospitalsNH$25Washington: median $39 across 28 hospitalsWA$39Idaho: 6 hospitals filed a usable price — fewer than 10, so no figureIDMontana: median $35 across 20 hospitalsMT$35North Dakota: median $59 across 18 hospitalsND$59Minnesota: median $45 across 70 hospitalsMN$45Illinois: median $46 across 82 hospitalsIL$46Wisconsin: median $63 across 82 hospitalsWI$63Michigan: median $50 across 57 hospitalsMI$50New York: median $43 across 44 hospitalsNY$43Massachusetts: median $134 across 25 hospitalsMA$134Oregon: median $59 across 16 hospitalsOR$59Nevada: 8 hospitals filed a usable price — fewer than 10, so no figureNVWyoming: median $47 across 11 hospitalsWY$47South Dakota: median $62 across 22 hospitalsSD$62Iowa: median $60 across 51 hospitalsIA$60Indiana: median $32 across 71 hospitalsIN$32Ohio: median $72 across 66 hospitalsOH$72Pennsylvania: median $35 across 68 hospitalsPA$35New Jersey: median $19 across 44 hospitalsNJ$19Connecticut: median $72 across 10 hospitalsCT$72Rhode Island: 5 hospitals filed a usable price — fewer than 10, so no figureRICalifornia: median $24 across 91 hospitalsCA$24Utah: median $83 across 34 hospitalsUT$83Colorado: median $32 across 47 hospitalsCO$32Nebraska: median $48 across 55 hospitalsNE$48Missouri: median $31 across 49 hospitalsMO$31Kentucky: median $80 across 36 hospitalsKY$80West Virginia: median $24 across 30 hospitalsWV$24Virginia: median $88 across 23 hospitalsVA$88Maryland: median $179 across 19 hospitalsMD$179Delaware: 3 hospitals filed a usable price — fewer than 10, so no figureDEArizona: median $36 across 13 hospitalsAZ$36New Mexico: 7 hospitals filed a usable price — fewer than 10, so no figureNMKansas: median $79 across 22 hospitalsKS$79Arkansas: median $33 across 29 hospitalsAR$33Tennessee: median $19 across 40 hospitalsTN$19North Carolina: median $90 across 66 hospitalsNC$90South Carolina: median $103 across 35 hospitalsSC$103Oklahoma: median $35 across 49 hospitalsOK$35Louisiana: median $40 across 20 hospitalsLA$40Mississippi: median $22 across 43 hospitalsMS$22Alabama: median $16 across 10 hospitalsAL$16Georgia: median $69 across 53 hospitalsGA$69Hawaii: median $75 across 11 hospitalsHI$75Texas: median $88 across 143 hospitalsTX$88Florida: median $50 across 77 hospitalsFL$50
Cash price by state, most expensive first. National median $49. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Maryland MD19$179+262%$78 – $234
Massachusetts MA25$134+171%$59 – $179
Alaska AK10$108+120%$56 – $139
South Carolina SC35$103+109%$39 – $149
North Carolina NC66$90+83%$38 – $158
Texas TX143$88+79%$34 – $187
Virginia VA23$88+78%$32 – $94
Utah UT34$83+69%$69 – $98
Kentucky KY36$80+61%$19 – $158
Kansas KS22$79+61%$48 – $107
Hawaii HI11$75+52%$55 – $235
Ohio OH66$72+46%$46 – $332
Connecticut CT10$72+46%$43 – $90
Georgia GA53$69+39%$48 – $78
Wisconsin WI82$63+28%$24 – $120
South Dakota SD22$62+25%$49 – $131
Iowa IA51$60+23%$34 – $77
North Dakota ND18$59+19%$30 – $132
Oregon OR16$59+19%$40 – $83
Florida FL77$50+2%$20 – $93
Michigan MI57$50+1%$30 – $106
Nebraska NE55$48−3%$21 – $69
Wyoming WY11$47−5%$24 – $74
Illinois IL82$46−6%$25 – $115
Minnesota MN70$45−10%$32 – $101
New York NY44$43−13%$17 – $72
Louisiana LA20$40−18%$20 – $70
Washington WA28$39−20%$33 – $97
Arizona AZ13$36−27%$19 – $51
Oklahoma OK49$35−28%$16 – $58
Pennsylvania PA68$35−30%$19 – $226
Montana MT20$35−30%$17 – $63
Arkansas AR29$33−33%$11 – $56
Indiana IN71$32−35%$21 – $69
Colorado CO47$32−35%$20 – $113
Missouri MO49$31−37%$15 – $47
New Hampshire NH10$25−49%$13 – $27
California CA91$24−51%$14 – $63
West Virginia WV30$24−52%$21 – $86
Mississippi MS43$22−56%$9 – $39
New Jersey NJ44$19−62%$17 – $92
Tennessee TN40$19−62%$5 – $29
Alabama AL10$16−68%$6 – $53
Nevada NV8not enough hospitals filed a usable price
New Mexico NM7not enough hospitals filed a usable price
Idaho ID6not enough hospitals filed a usable price
Rhode Island RI5not enough hospitals filed a usable price
Delaware DE3not enough hospitals filed a usable price
Maine ME3not enough hospitals filed a usable price
Vermont VT2not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $49.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care1,377$48$20 – $103
Children’s56$115$30 – $495
Critical access393$58$27 – $103
Ownership
For-profit243$59$23 – $203
Government276$54$24 – $104
Non-profit1,307$48$22 – $103
System affiliation
Part of a system1,590$49$23 – $104
Independent244$53$23 – $113

Cash price vs list price

Median list price (chargemaster)$88
Median cash price$49
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

1,258 hospitals filed a usable inpatient cash price for this code. The median is $56 and the average of the middle 60% is $60; most fall between $27 and $104.

Cash price percentiles, inpatient, across 1,258 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$19$32$56$93$169

The most expensive tenth of hospitals charges at least 9.0× what the cheapest tenth charges ($19 vs $169).

Of the 1,371 hospitals that filed this code inpatient, 1,258 gave a usable cash price; 61 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 52 a list price only.

How complete is this

1,834 of the 3,956 hospitals with a price file in our corpus (46%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 1,969 hospitals that filed this code at all gave us
Usable cash price — counted1,834
Cash price carrying a plausibility flag — shown on the compare tool, excluded here80
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded0
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded55
Hospitals that filed this code1,969

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 25, 2026; the figures were computed September 25, 2026 from filings loaded through September 25, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Laboratory - Chemistry and Hematology family.

Hospitals file this code under descriptions such as HC Biotinidase.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Biotinidase enzyme blood test (CPT 82261) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-82261-biotinidase-enzyme-blood-test