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Procedure price report · Other Laboratory

Confirmatory test for 6 or more non-opioid pain drugs

CPT 80331the billing code this page is about

A definitive laboratory test measuring six or more non-opioid pain medicines in one sample; billed once for the whole group.

Hospitals typically charge $33 cash for this outpatient procedure — the median across 424 hospitals that filed a usable cash price; the average of the middle 60% is $45. Most fall between $10 and $127 (20th–80th percentile).

Hospitals
424
States
43
Filings dated
Jan 2024 – Sep 2026
Computed
September 25, 2026
Prices checked
through September 24, 2026

Median: half of hospitals filed less, half more — and it is a price some hospital actually filed. Average of the middle 60%: the mean of the prices between the 20th and 80th percentiles. We never publish the plain average, the lowest or the highest price: the extremes in hospital price files are chargemaster artefacts, not prices anyone pays.

What hospitals charge, from cheapest to most expensive

Cash price percentiles, outpatient, across 424 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$7$12$33$108$255

The most expensive tenth of hospitals charges at least 38× what the cheapest tenth charges ($7 vs $255).

How the prices are spread

$5 – $8: 29 hospitals$5$8 – $13: 62 hospitals$13 – $21: 82 hospitals$13$21 – $35: 37 hospitals$35 – $58: 30 hospitals$35$58 – $96: 50 hospitals$96 – $158: 58 hospitals$96$158 – $261: 14 hospitals$261 – $430: 17 hospitals$261$430 – $709: 5 hospitals$430median $33price bands are equal on a log scale
Hospitals per price band (384 of 424 — the bands cover the 5th to 95th percentile)
FromToHospitals
$5$829
$8$1362
$13$2182
$21$3537
$35$5830
$58$9650
$96$15858
$158$26114
$261$43017
$430$7095

By state

The median cash price in each state, against the national median of $33.

Alaska: no hospital in the corpus filed a usable priceAKMaine: 1 hospital filed a usable price — fewer than 10, so no figureMEVermont: no hospital in the corpus filed a usable priceVTNew Hampshire: 1 hospital filed a usable price — fewer than 10, so no figureNHWashington: median $17 across 13 hospitalsWA$17Idaho: 2 hospitals filed a usable price — fewer than 10, so no figureIDMontana: 2 hospitals filed a usable price — fewer than 10, so no figureMTNorth Dakota: 4 hospitals filed a usable price — fewer than 10, so no figureNDMinnesota: 7 hospitals filed a usable price — fewer than 10, so no figureMNIllinois: median $21 across 18 hospitalsIL$21Wisconsin: median $9 across 14 hospitalsWI$9Michigan: 3 hospitals filed a usable price — fewer than 10, so no figureMINew York: median $29 across 17 hospitalsNY$29Massachusetts: 8 hospitals filed a usable price — fewer than 10, so no figureMAOregon: 5 hospitals filed a usable price — fewer than 10, so no figureORNevada: 1 hospital filed a usable price — fewer than 10, so no figureNVWyoming: no hospital in the corpus filed a usable priceWYSouth Dakota: 3 hospitals filed a usable price — fewer than 10, so no figureSDIowa: median $12 across 15 hospitalsIA$12Indiana: median $19 across 17 hospitalsIN$19Ohio: median $21 across 21 hospitalsOH$21Pennsylvania: median $709 across 11 hospitalsPA$709New Jersey: median $63 across 18 hospitalsNJ$63Connecticut: 1 hospital filed a usable price — fewer than 10, so no figureCTRhode Island: no hospital in the corpus filed a usable priceRICalifornia: median $14 across 35 hospitalsCA$14Utah: median $108 across 27 hospitalsUT$108Colorado: 1 hospital filed a usable price — fewer than 10, so no figureCONebraska: 2 hospitals filed a usable price — fewer than 10, so no figureNEMissouri: 2 hospitals filed a usable price — fewer than 10, so no figureMOKentucky: median $16 across 16 hospitalsKY$16West Virginia: median $5 across 10 hospitalsWV$5Virginia: median $28 across 15 hospitalsVA$28Maryland: 4 hospitals filed a usable price — fewer than 10, so no figureMDDelaware: no hospital in the corpus filed a usable priceDEArizona: 6 hospitals filed a usable price — fewer than 10, so no figureAZNew Mexico: no hospital in the corpus filed a usable priceNMKansas: no hospital in the corpus filed a usable priceKSArkansas: 2 hospitals filed a usable price — fewer than 10, so no figureARTennessee: median $34 across 14 hospitalsTN$34North Carolina: median $14 across 26 hospitalsNC$14South Carolina: median $10 across 19 hospitalsSC$10Oklahoma: 2 hospitals filed a usable price — fewer than 10, so no figureOKLouisiana: 9 hospitals filed a usable price — fewer than 10, so no figureLAMississippi: 7 hospitals filed a usable price — fewer than 10, so no figureMSAlabama: 6 hospitals filed a usable price — fewer than 10, so no figureALGeorgia: median $156 across 19 hospitalsGA$156Hawaii: 1 hospital filed a usable price — fewer than 10, so no figureHITexas: median $47 across 16 hospitalsTX$47Florida: 3 hospitals filed a usable price — fewer than 10, so no figureFL
Cash price by state, most expensive first. National median $33. A state needs at least 10 hospitals with a usable price to show a figure.
StateHospitalsMedianvs national20th–80th
Pennsylvania PA11$709+2044%$352 – $769
Georgia GA19$156+373%$156 – $156
Utah UT27$108+225%$108 – $127
New Jersey NJ18$63+90%$60 – $1,120
Texas TX16$47+42%$4 – $1,288
Tennessee TN14$34+2%$33 – $34
New York NY17$29−12%$12 – $141
Virginia VA15$28−17%$4 – $34
Illinois IL18$21−37%$11 – $91
Ohio OH21$21−37%$13 – $38
Indiana IN17$19−43%$9 – $262
Washington WA13$17−49%$16 – $71
Kentucky KY16$16−53%$7 – $59
California CA35$14−58%$14 – $76
North Carolina NC26$14−58%$14 – $84
Iowa IA15$12−64%$12 – $12
South Carolina SC19$10−71%$10 – $15
Wisconsin WI14$9−74%$5 – $131
West Virginia WV10$5−85%$5 – $9
Louisiana LA9not enough hospitals filed a usable price
Massachusetts MA8not enough hospitals filed a usable price
Minnesota MN7not enough hospitals filed a usable price
Mississippi MS7not enough hospitals filed a usable price
Alabama AL6not enough hospitals filed a usable price
Arizona AZ6not enough hospitals filed a usable price
Oregon OR5not enough hospitals filed a usable price
Maryland MD4not enough hospitals filed a usable price
North Dakota ND4not enough hospitals filed a usable price
Florida FL3not enough hospitals filed a usable price
Michigan MI3not enough hospitals filed a usable price
South Dakota SD3not enough hospitals filed a usable price
Arkansas AR2not enough hospitals filed a usable price
Idaho ID2not enough hospitals filed a usable price
Missouri MO2not enough hospitals filed a usable price
Montana MT2not enough hospitals filed a usable price
Nebraska NE2not enough hospitals filed a usable price
Oklahoma OK2not enough hospitals filed a usable price
Colorado CO1not enough hospitals filed a usable price
Connecticut CT1not enough hospitals filed a usable price
Hawaii HI1not enough hospitals filed a usable price
Maine ME1not enough hospitals filed a usable price
New Hampshire NH1not enough hospitals filed a usable price
Nevada NV1not enough hospitals filed a usable price

Hospitals like yours

The same distribution cut by the kind of hospital. Hospital type and ownership come from CMS; a hospital counts as part of a system when its price file is shared with at least one other hospital under the same brand. The national median is $33.

Cash price by hospital segment. A segment needs at least 20 hospitals to show a figure.
SegmentHospitalsMedian20th–80th
Hospital type
Acute care330$34$12 – $150
Children’s7fewer than 20 hospitals
Critical access85$21$9 – $98
Ownership
For-profit40$82$10 – $177
Government52$14$9 – $118
Non-profit330$33$10 – $113
System affiliation
Part of a system367$34$11 – $127
Independent57$19$10 – $91

Cash price vs list price

Median list price (chargemaster)$50
Median cash price$33
Cash as a share of list, median hospital60%

At the typical hospital, asking for the cash price cuts the list price by about 40%. The share is the median of each hospital’s own cash ÷ list ratio, over hospitals that filed both — not the ratio of the two medians above.

The same procedure, inpatient

325 hospitals filed a usable inpatient cash price for this code. The median is $33 and the average of the middle 60% is $46; most fall between $12 and $127.

Cash price percentiles, inpatient, across 325 hospitals. Each figure is a price a hospital filed. 10th: one in ten hospitals charges less; 25th: a quarter charge less; Median: half charge less; 75th: three quarters charge less; 90th: nine in ten charge less.
10th25thMedian75th90th
$8$14$33$108$175

The most expensive tenth of hospitals charges at least 21× what the cheapest tenth charges ($8 vs $175).

Of the 340 hospitals that filed this code inpatient, 325 gave a usable cash price; 4 carried a plausibility flag, 0 filed a number their own filing marks as not a price, 0 gave an estimate, and 11 a list price only.

How complete is this

424 of the 3,956 hospitals with a price file in our corpus (11%) filed a usable outpatient cash price for this code, and those are the hospitals every figure on this page is computed from.

What the 468 hospitals that filed this code at all gave us
Usable cash price — counted424
Cash price carrying a plausibility flag — shown on the compare tool, excluded here8
A number the filing itself marks as not a price (a placeholder, a ratio) — excluded5
An estimate rather than a filed cash price — excluded0
A list price only, no cash figure — excluded31
Hospitals that filed this code468

Sections not shown for this setting

  • Against Medicare: Medicare has no separately payable national outpatient (OPPS) rate for this code, so there is nothing honest to compare against.
  • Since our last snapshot: there is no earlier snapshot at least 90 days older than this one yet.

We last checked these hospitals’ price files for changes between September 4, 2026 and September 24, 2026; the figures were computed September 25, 2026 from filings loaded through September 23, 2026. The percentiles and averages use only the “counted” row.

Related procedures

Part of the Other Laboratory family.

Hospitals file this code under descriptions such as ANALGESICS NON-OPIOID 6/MORE.

Method

Source
The machine-readable price files every U.S. hospital is required by CMS to publish, parsed per hospital. Nothing is surveyed, sampled or modelled.
What counts
One cash (self-pay) price per hospital for this code and setting. A hospital’s own filing can rule its number out — a placeholder, a “not applicable” note, a list price standing in for cash — and our plausibility checks can flag a price far below what every other hospital files. Both kinds are disclosed above and excluded from the statistics; on the compare tool a flagged price is still shown.
Statistics
Percentiles are discrete: each is a price some hospital filed. The average is the mean of the prices between the 20th and 80th percentiles. We never publish the plain mean, the minimum or the maximum. A state needs 10 hospitals and a segment 20 to show a figure; otherwise the row shows its count and no number. Medicare is the national unadjusted OPPS rate where one exists.
Names
Procedure names on these pages are our own plain-language titles, not the AMA’s copyrighted CPT descriptors. The code is the identity.

The full rules — sources, statistics, thresholds, limitations — are on the methodology page.

Download this page’s figures: JSON · CSV. Aggregates only — the per-hospital prices are on the compare tool.

Cite: HospitalRates.com, “Confirmatory test for 6 or more non-opioid pain drugs (CPT 80331) — cash price report,” computed September 25, 2026. https://hospitalrates.com/procedures/cpt-80331-confirmatory-test-for-6-or-more-non-opioid-pain-drugs