{"procedure":{"code_type":"CPT","code":"81288","lay_name":"MLH1 gene methylation test","blurb":"A laboratory test that checks whether the control region of the MLH1 gene is chemically silenced in a tissue or blood sample, used in evaluating Lynch syndrome and related tumors.","slug":"cpt-81288-mlh1-gene-methylation-test","description":"MLH1 GENE","name_source":"llm:claude-opus-5","name_reviewed":false,"ccs":{"code":"234","label":"Pathology","surgery_flag":"n/a"}},"settings":{"outpatient":{"setting":"outpatient","computed_at":"2026-09-25T11:55:12.319193Z","corpus_loaded_through":"2026-09-25T01:10:45.071082Z","filing_date_min":"2024-01-24","filing_date_max":"2026-09-22","checked_from":"2026-09-05T02:22:45.003818Z","checked_through":"2026-09-25T01:14:07.150894Z","n_priced_setters":3956,"n_filed":1578,"n_usable":1450,"n_not_usable":2,"n_labelled":82,"n_no_cash":44,"n_estimated":0,"n_states":50,"cash_p10":185.59,"cash_p20":229.89,"cash_p25":273.7,"cash_p50":405.0,"cash_p75":593.19,"cash_p80":649.0,"cash_p90":875.0,"cash_mean_trimmed":411.51,"gross_p50":693.31,"cash_to_gross_p50":0.6,"medicare_rate":null,"medicare_schedule":null,"medicare_year":null,"cash_to_medicare_p50":null,"by_state":[{"state":"AK","n":4,"p20":null,"p50":null,"p80":null},{"state":"AL","n":12,"p20":211.95,"p50":342.88,"p80":499.0},{"state":"AR","n":12,"p20":189.23,"p50":333.45,"p80":338.65},{"state":"AZ","n":25,"p20":189.25,"p50":375.0,"p80":1629.0},{"state":"CA","n":38,"p20":252.0,"p50":442.4,"p80":442.4},{"state":"CO","n":19,"p20":269.73,"p50":322.57,"p80":1941.68},{"state":"CT","n":13,"p20":264.18,"p50":617.35,"p80":818.0},{"state":"DE","n":5,"p20":null,"p50":null,"p80":null},{"state":"FL","n":52,"p20":189.6,"p50":294.7,"p80":664.95},{"state":"GA","n":62,"p20":358.63,"p50":369.0,"p80":649.0},{"state":"HI","n":4,"p20":null,"p50":null,"p80":null},{"state":"IA","n":25,"p20":184.63,"p50":283.4,"p80":440.58},{"state":"ID","n":10,"p20":341.25,"p50":355.09,"p80":362.76},{"state":"IL","n":54,"p20":185.59,"p50":543.9,"p80":610.0},{"state":"IN","n":68,"p20":150.39,"p50":348.6,"p80":586.2},{"state":"KS","n":13,"p20":283.8,"p50":861.0,"p80":1034.84},{"state":"KY","n":22,"p20":229.0,"p50":522.32,"p80":551.21},{"state":"LA","n":20,"p20":111.09,"p50":153.6,"p80":309.4},{"state":"MA","n":32,"p20":427.0,"p50":693.0,"p80":825.0},{"state":"MD","n":24,"p20":289.47,"p50":613.7,"p80":752.76},{"state":"ME","n":13,"p20":164.0,"p50":467.05,"p80":500.05},{"state":"MI","n":58,"p20":182.0,"p50":297.14,"p80":711.0},{"state":"MN","n":60,"p20":343.98,"p50":440.0,"p80":468.66},{"state":"MO","n":30,"p20":284.7,"p50":382.2,"p80":408.2},{"state":"MS","n":9,"p20":null,"p50":null,"p80":null},{"state":"MT","n":2,"p20":null,"p50":null,"p80":null},{"state":"NC","n":44,"p20":229.14,"p50":358.63,"p80":372.96},{"state":"ND","n":6,"p20":null,"p50":null,"p80":null},{"state":"NE","n":7,"p20":null,"p50":null,"p80":null},{"state":"NH","n":10,"p20":187.03,"p50":441.05,"p80":731.2},{"state":"NJ","n":41,"p20":192.32,"p50":211.55,"p80":299.46},{"state":"NM","n":11,"p20":333.2,"p50":403.2,"p80":506.7},{"state":"NV","n":6,"p20":null,"p50":null,"p80":null},{"state":"NY","n":53,"p20":192.32,"p50":338.0,"p80":838.0},{"state":"OH","n":92,"p20":308.0,"p50":424.8,"p80":862.55},{"state":"OK","n":34,"p20":115.4,"p50":216.6,"p80":441.35},{"state":"OR","n":13,"p20":260.0,"p50":377.76,"p80":437.45},{"state":"PA","n":72,"p20":253.6,"p50":587.88,"p80":1123.8},{"state":"RI","n":4,"p20":null,"p50":null,"p80":null},{"state":"SC","n":26,"p20":445.2,"p50":633.1,"p80":653.0},{"state":"SD","n":1,"p20":null,"p50":null,"p80":null},{"state":"TN","n":29,"p20":138.04,"p50":284.97,"p80":290.4},{"state":"TX","n":84,"p20":271.62,"p50":288.48,"p80":703.01},{"state":"UT","n":25,"p20":362.76,"p50":362.76,"p80":426.78},{"state":"VA","n":58,"p20":267.76,"p50":318.3,"p80":636.6},{"state":"VT","n":5,"p20":null,"p50":null,"p80":null},{"state":"WA","n":39,"p20":229.89,"p50":344.0,"p80":446.6},{"state":"WI","n":80,"p20":450.0,"p50":478.18,"p80":695.75},{"state":"WV","n":20,"p20":295.0,"p50":369.43,"p80":918.4},{"state":"WY","n":4,"p20":null,"p50":null,"p80":null}],"by_segment":{"hospital_type":[{"key":"acute","n":1188,"p20":221.17,"p50":376.32,"p80":653.0},{"key":"childrens","n":11,"p20":null,"p50":null,"p80":null},{"key":"critical_access","n":244,"p20":288.48,"p50":437.45,"p80":623.84}],"ownership":[{"key":"for_profit","n":141,"p20":244.63,"p50":405.6,"p80":872.25},{"key":"government","n":164,"p20":221.17,"p50":363.22,"p80":576.96},{"key":"nonprofit","n":1138,"p20":230.78,"p50":410.4,"p80":636.8}],"affiliation":[{"key":"affiliated","n":1317,"p20":232.96,"p50":408.24,"p80":649.0},{"key":"independent","n":133,"p20":218.35,"p50":350.35,"p80":622.2}]},"histogram":[{"lo":132.3,"hi":165.35,"n":31},{"lo":165.35,"hi":206.65,"n":113},{"lo":206.65,"hi":258.26,"n":121},{"lo":258.26,"hi":322.77,"n":212},{"lo":322.77,"hi":403.4,"n":174},{"lo":403.4,"hi":504.16,"n":241},{"lo":504.16,"hi":630.09,"n":168},{"lo":630.09,"hi":787.47,"n":105},{"lo":787.47,"hi":984.17,"n":102},{"lo":984.17,"hi":1230.0,"n":39}],"previous":null},"inpatient":{"setting":"inpatient","computed_at":"2026-09-25T11:55:12.319193Z","corpus_loaded_through":"2026-09-25T01:10:45.071082Z","filing_date_min":"2024-01-24","filing_date_max":"2026-09-21","checked_from":"2026-09-05T02:23:05.982663Z","checked_through":"2026-09-25T01:14:07.150894Z","n_priced_setters":3956,"n_filed":1237,"n_usable":1112,"n_not_usable":1,"n_labelled":79,"n_no_cash":45,"n_estimated":0,"n_states":48,"cash_p10":185.0,"cash_p20":246.5,"cash_p25":284.97,"cash_p50":424.55,"cash_p75":610.0,"cash_p80":666.0,"cash_p90":878.9,"cash_mean_trimmed":428.29,"gross_p50":711.0,"cash_to_gross_p50":0.6,"medicare_rate":null,"medicare_schedule":null,"medicare_year":null,"cash_to_medicare_p50":null,"by_state":[{"state":"AL","n":6,"p20":null,"p50":null,"p80":null},{"state":"AR","n":4,"p20":null,"p50":null,"p80":null},{"state":"AZ","n":24,"p20":206.17,"p50":386.4,"p80":1629.0},{"state":"CA","n":32,"p20":385.0,"p50":442.4,"p80":442.4},{"state":"CO","n":12,"p20":249.26,"p50":322.57,"p80":322.57},{"state":"CT","n":6,"p20":null,"p50":null,"p80":null},{"state":"DE","n":4,"p20":null,"p50":null,"p80":null},{"state":"FL","n":36,"p20":189.6,"p50":429.5,"p80":664.95},{"state":"GA","n":58,"p20":363.22,"p50":410.4,"p80":649.0},{"state":"HI","n":2,"p20":null,"p50":null,"p80":null},{"state":"IA","n":19,"p20":184.63,"p50":184.63,"p80":305.2},{"state":"ID","n":9,"p20":null,"p50":null,"p80":null},{"state":"IL","n":41,"p20":355.2,"p50":482.0,"p80":720.72},{"state":"IN","n":47,"p20":126.45,"p50":448.8,"p80":586.2},{"state":"KS","n":6,"p20":null,"p50":null,"p80":null},{"state":"KY","n":14,"p20":180.95,"p50":405.0,"p80":576.96},{"state":"LA","n":14,"p20":136.35,"p50":173.4,"p80":516.5},{"state":"MA","n":32,"p20":427.0,"p50":693.0,"p80":825.0},{"state":"MD","n":17,"p20":277.68,"p50":454.97,"p80":752.76},{"state":"ME","n":13,"p20":164.0,"p50":467.05,"p80":500.05},{"state":"MI","n":46,"p20":178.5,"p50":311.35,"p80":711.0},{"state":"MN","n":47,"p20":371.31,"p50":449.09,"p80":476.43},{"state":"MO","n":14,"p20":283.8,"p50":382.2,"p80":620.5},{"state":"MS","n":8,"p20":null,"p50":null,"p80":null},{"state":"MT","n":1,"p20":null,"p50":null,"p80":null},{"state":"NC","n":34,"p20":229.14,"p50":358.63,"p80":372.96},{"state":"ND","n":5,"p20":null,"p50":null,"p80":null},{"state":"NE","n":3,"p20":null,"p50":null,"p80":null},{"state":"NH","n":9,"p20":null,"p50":null,"p80":null},{"state":"NJ","n":16,"p20":221.17,"p50":221.17,"p80":601.47},{"state":"NM","n":9,"p20":null,"p50":null,"p80":null},{"state":"NV","n":5,"p20":null,"p50":null,"p80":null},{"state":"NY","n":33,"p20":338.0,"p50":563.75,"p80":962.0},{"state":"OH","n":90,"p20":303.6,"p50":424.8,"p80":862.55},{"state":"OK","n":23,"p20":115.4,"p50":118.96,"p80":376.32},{"state":"OR","n":3,"p20":null,"p50":null,"p80":null},{"state":"PA","n":68,"p20":253.6,"p50":592.11,"p80":1123.8},{"state":"SC","n":26,"p20":445.2,"p50":633.1,"p80":653.0},{"state":"SD","n":1,"p20":null,"p50":null,"p80":null},{"state":"TN","n":23,"p20":138.04,"p50":284.97,"p80":290.4},{"state":"TX","n":74,"p20":271.62,"p50":288.48,"p80":418.2},{"state":"UT","n":22,"p20":362.76,"p50":362.76,"p80":426.78},{"state":"VA","n":45,"p20":257.5,"p50":310.0,"p80":636.6},{"state":"VT","n":3,"p20":null,"p50":null,"p80":null},{"state":"WA","n":32,"p20":235.6,"p50":334.58,"p80":446.4},{"state":"WI","n":66,"p20":455.0,"p50":526.9,"p80":695.75},{"state":"WV","n":6,"p20":null,"p50":null,"p80":null},{"state":"WY","n":4,"p20":null,"p50":null,"p80":null}],"by_segment":{"hospital_type":[{"key":"acute","n":935,"p20":230.78,"p50":410.4,"p80":664.95},{"key":"childrens","n":9,"p20":null,"p50":null,"p80":null},{"key":"critical_access","n":161,"p20":288.48,"p50":458.04,"p80":664.95}],"ownership":[{"key":"for_profit","n":98,"p20":288.2,"p50":403.87,"p80":804.75},{"key":"government","n":110,"p20":269.73,"p50":372.96,"p80":588.0},{"key":"nonprofit","n":897,"p20":235.8,"p50":435.0,"p80":673.4}],"affiliation":[{"key":"affiliated","n":1026,"p20":249.26,"p50":426.78,"p80":673.4},{"key":"independent","n":86,"p20":212.1,"p50":350.35,"p80":578.5}]},"histogram":[{"lo":130.78,"hi":162.66,"n":20},{"lo":162.66,"hi":202.31,"n":76},{"lo":202.31,"hi":251.63,"n":80},{"lo":251.63,"hi":312.97,"n":133},{"lo":312.97,"hi":389.26,"n":158},{"lo":389.26,"hi":484.15,"n":172},{"lo":484.15,"hi":602.17,"n":134},{"lo":602.17,"hi":748.95,"n":94},{"lo":748.95,"hi":931.52,"n":92},{"lo":931.52,"hi":1158.6,"n":43}],"previous":null}},"related":[{"code_type":"CPT","code":"88305","lay_name":"Tissue exam under microscope, moderate complexity","slug":"cpt-88305-tissue-exam-under-microscope-moderate-complexity"},{"code_type":"CPT","code":"88312","lay_name":"Special stain for germs such as bacteria or fungus","slug":"cpt-88312-special-stain-for-germs-such-as-bacteria-or-fungus"},{"code_type":"CPT","code":"88342","lay_name":"Special tissue stain for one marker, first stain","slug":"cpt-88342-special-tissue-stain-for-one-marker-first-stain"},{"code_type":"CPT","code":"88304","lay_name":"Tissue exam under microscope, low complexity","slug":"cpt-88304-tissue-exam-under-microscope-low-complexity"},{"code_type":"CPT","code":"88313","lay_name":"Special tissue stain for cell structures","slug":"cpt-88313-special-tissue-stain-for-cell-structures"},{"code_type":"CPT","code":"88307","lay_name":"Tissue exam under microscope, high complexity","slug":"cpt-88307-tissue-exam-under-microscope-high-complexity"},{"code_type":"CPT","code":"81241","lay_name":"Factor V Leiden blood clotting gene mutation test","slug":"cpt-81241-factor-v-leiden-blood-clotting-gene-mutation-test"},{"code_type":"CPT","code":"88302","lay_name":"Tissue exam under microscope, simplest level","slug":"cpt-88302-tissue-exam-under-microscope-simplest-level"},{"code_type":"CPT","code":"88184","lay_name":"Flow cytometry cell marker testing, first marker","slug":"cpt-88184-flow-cytometry-cell-marker-testing-first-marker"},{"code_type":"CPT","code":"88341","lay_name":"Special tissue stain for one more marker","slug":"cpt-88341-special-tissue-stain-for-one-more-marker"},{"code_type":"CPT","code":"88300","lay_name":"Tissue exam by eye only, no microscope","slug":"cpt-88300-tissue-exam-by-eye-only-no-microscope"},{"code_type":"CPT","code":"81240","lay_name":"Prothrombin blood clotting gene mutation test","slug":"cpt-81240-prothrombin-blood-clotting-gene-mutation-test"}]}